Patents by Inventor Eli N. Glezer

Eli N. Glezer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LINKED PAIRED STRAND SEQUENCING
    Publication number: 20220119878
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Application
    Filed: October 13, 2021
    Publication date: April 21, 2022
    Inventors: Eli N. Glezer, Martin Maria Fabani, Timothy Looney, Sabrina Shore, Ryan Shultzaberger, Daan Witters
  • ENGINEERED PYROCOCCUS ENZYMES AND USES THEREOF
    Publication number: 20220119780
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: October 5, 2021
    Publication date: April 21, 2022
    Inventors: Souad NAJI, Eli N. GLEZER, Youngjin CHO, Zachary TERRANOVA, Abrehet ABDU
  • Assay apparatuses, methods and reagents
    Patent number: 11300571
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: April 12, 2022
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
  • POLYNUCLEOTIDE BARCODES FOR LONG READ SEQUENCING
    Publication number: 20220106636
    Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.
    Type: Application
    Filed: September 27, 2021
    Publication date: April 7, 2022
    Inventors: Eli N. GLEZER, Martin Maria FABANI, Ryan SHULTZABERGER, Bharat SRIDHAR, Gudrun STENGEL, Christopher Jen-Yue WEI
  • ASSAY CARTRIDGE VALVE SYSTEM
    Publication number: 20220097072
    Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.
    Type: Application
    Filed: October 1, 2021
    Publication date: March 31, 2022
    Inventors: Eli N. GLEZER, Bandele JEFFREY-COKER, Kenneth PAGE, Sandor KOVACS, Sudeep KUMAR, Kristian ROTH
  • COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING
    Publication number: 20220090191
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Application
    Filed: December 3, 2021
    Publication date: March 24, 2022
    Inventors: Eli N. GLEZER, Mohammad Vatankhah VARNOSFADERANI, Daan WITTERS, Vahid KARIMKHANI
  • METHODS FOR IN SITU TRANSCRIPTOMICS AND PROTEOMICS
    Publication number: 20220042083
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Application
    Filed: August 6, 2021
    Publication date: February 10, 2022
    Inventors: Eli N. GLEZER, Hu CANG, Zhenmin HONG
  • SPATIAL SEQUENCING
    Publication number: 20220042084
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Application
    Filed: August 6, 2021
    Publication date: February 10, 2022
    Inventor: Eli N. GLEZER
  • POLYNUCLEOTIDE BARCODES FOR LONG READ SEQUENCING
    Publication number: 20220042087
    Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.
    Type: Application
    Filed: October 8, 2021
    Publication date: February 10, 2022
    Inventors: Eli N. GLEZER, Martin Maria FABANI, Ryan SHULTZABERGER, Bharat SRIDHAR, Gudrun STENGEL, Christopher Jen-Yue WEI
  • Co-binder assisted assay methods
    Patent number: 11242570
    Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: February 8, 2022
    Assignee: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, George Sigal
  • CO-BINDER ASSISTED ASSAY METHODS
    Publication number: 20220033918
    Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 3, 2022
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, George Sigal
  • LINKED PAIRED STRAND SEQUENCING
    Publication number: 20220033895
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Application
    Filed: October 13, 2021
    Publication date: February 3, 2022
    Inventors: Eli N. Glezer, Martin Maria Fabani, Timothy Looney, Sabrina Shore, Ryan Shultzaberger, Daan Witters
  • Compositions and methods for nucleic acid sequencing
    Patent number: 11236387
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: February 1, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • ASSAY APPARATUSES, METHODS AND REAGENTS
    Publication number: 20220019053
    Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
    Type: Application
    Filed: October 1, 2021
    Publication date: January 20, 2022
    Inventors: Ian CHAMBERLIN, Charles M. CLINTON, Eli N. GLEZER, Bandele JEFFREY-COKER, Manish KOCHAR, Sandor KOVACS, D.T. Le, Aaron LEIMKUEHLER, George SIGAL, Leo TABAKIN, Jon WILLOUGHBY
  • Methods for long read sequencing
    Patent number: 11225688
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: January 18, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • METHODS FOR CONDUCTING MULTIPLEXED ASSAYS
    Publication number: 20210402390
    Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
    Type: Application
    Filed: September 16, 2021
    Publication date: December 30, 2021
    Inventors: Eli N. Glezer, Sudeep Kumar, Pankaj Oberoi, George Sigal, Michael Tsionsky
  • BIDIRECTIONAL FLUID FLOW IN A MICROFLUIDIC DEVICE
    Publication number: 20210402397
    Abstract: Provided herein, inter alia, are nucleic acid sequencing devices and flow cells containing different flow paths to control the flow of fluidic solutions.
    Type: Application
    Filed: June 22, 2021
    Publication date: December 30, 2021
    Inventors: Tuan Tran, Terrence Murphy, Eli N. Glezer
  • GLOMERULONEPHRITIS BIOMARKERS
    Publication number: 20210373033
    Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: February 8, 2021
    Publication date: December 2, 2021
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, John Kenten, Galina Nikolenko
  • BIOMARKERS OF THERAPEUTIC RESPONSIVENESS
    Publication number: 20210364505
    Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: August 5, 2021
    Publication date: November 25, 2021
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Anu Mathew
  • Imaging Systems and Methods Useful for Patterned Structures
    Publication number: 20210350533
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for identifying and/or quantifying features in patterns.
    Type: Application
    Filed: May 5, 2021
    Publication date: November 11, 2021
    Inventors: Fedor Trintchouk, Eli N. Glezer