Patents by Inventor Elizabeth Jayne Wallace

Elizabeth Jayne Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PORE
    Publication number: 20220056517
    Abstract: A system for characterising a target polynucleotide, the system comprising a membrane and a pore complex; wherein the pore complex comprises: (i) a nanopore located in the membrane, and (ii) an auxiliary protein or peptide attached to the nanopore; wherein the nanopore and the auxiliary protein or peptide together form a continuous channel across the membrane, the channel comprising a first constriction region and a second constriction region; wherein the first constriction region is formed by a portion of the nanopore, and wherein the second constriction region is formed by at least a portion of the auxiliary protein or peptide.
    Type: Application
    Filed: November 7, 2019
    Publication date: February 24, 2022
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour, Andrew John Heron
  • NOVEL PROTEIN PORES
    Publication number: 20220024985
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 27, 2022
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
  • TRANSMEMBRANE PORE CONSISTING OF TWO CSGG PORES
    Publication number: 20220024994
    Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.
    Type: Application
    Filed: May 3, 2018
    Publication date: January 27, 2022
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, Han Remaut
  • Mutant pore
    Patent number: 11186868
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: November 30, 2021
    Assignee: Oxford Nanopore Technologies PLC
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • Modified enzymes
    Patent number: 11180741
    Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: November 23, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Andrew John Heron, Rebecca Victoria Bowen, Mark Bruce, Lakmal Jayasinghe, Joseph Hargreaves Lloyd, Szabolcs Soeroes, Elizabeth Jayne Wallace, Christopher Peter Youd
  • MUTANT LYSENIN PORES
    Publication number: 20210324020
    Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.
    Type: Application
    Filed: December 1, 2020
    Publication date: October 21, 2021
    Applicant: Oxford Nanopore Technologies Limited
    Inventors: Mark Bruce, James Anthony Clarke, Andrew John Heron, Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • MUTANT PORES
    Publication number: 20210317520
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
    Type: Application
    Filed: March 29, 2021
    Publication date: October 14, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • MUTANT CSGG PORES
    Publication number: 20210292376
    Abstract: The invention relates to mutant forms of CsgG. The invention also related to analyte detection and characterisation using CsgG.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 23, 2021
    Applicants: Oxford Nanopore Technologies Ltd., VIB VZW, Vrije Universiteit Brussel
    Inventors: Stefan Howorka, Han Remaut, Lakmal Jayasinghe, Elizabeth Jayne Wallace, James Clarke, Richard George Hambley, Jonathan Bankes Pugh
  • NOVEL PROTEIN PORES
    Publication number: 20210284696
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 16, 2021
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Van Der Verren, Nani Van Gerven, Lakmal Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, John Joseph Kilgour
  • MUTANT PORE
    Publication number: 20210269872
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 2, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • Mutant pores
    Patent number: 11034734
    Abstract: The invention relates to mutant forms of CsgG. The invention also related to analyte detection and characterisation using CsgG.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: June 15, 2021
    Assignees: Oxford Nanopore Technologies Ltd., VIB VZW, Vrije Universiteit Brussel
    Inventors: Stefan Howorka, Han Remaut, Lakmal Jayasinghe, Elizabeth Jayne Wallace, James Anthony Clarke, Richard George Hambley, Jonathan Bankes Pugh
  • TRANSMEMBRANE PORE CONSISTING OF TWO CSGG PORES
    Publication number: 20210147490
    Abstract: Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first Csg G pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.
    Type: Application
    Filed: May 3, 2018
    Publication date: May 20, 2021
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Jordan, Han Remaut
  • NOVEL PROTEIN PORES
    Publication number: 20210147486
    Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
    Type: Application
    Filed: July 2, 2018
    Publication date: May 20, 2021
    Applicants: Oxford Nanopore Technologies Limited, VIB VZW, Vrije Universiteit Brussel
    Inventors: Han Remaut, Sander Egbert Van Der Verren, Nani Van Gerven, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Pratik Raj Singh, Richard George Hambley, Michael Robert Jordan, John Joseph Kilgour
  • METHOD OF IMPROVING THE MOVEMENT OF A TARGET POLYNUCLEOTIDE WITH RESPECT TO A TRANSMEMBRANE PORE
    Publication number: 20210139972
    Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein.
    Type: Application
    Filed: October 20, 2020
    Publication date: May 13, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace, Jonathan Bankes Pugh, Richard George Hambley, Neil Roger Wood, Clive Gavin Brown, James White, Andrew John Heron, Mark Bruce, Christopher Peter Youd, Rebecca Victoria Bowen
  • Mutant pores
    Patent number: 10995372
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: May 4, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • MODIFIED HELICASES
    Publication number: 20210123032
    Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 29, 2021
    Applicant: Oxford Nanopore Technologies Limited
    Inventors: Andrew Heron, Anthony Clarke, Ruth Moysey, Elizabeth Jayne Wallace, Mark Bruce, Lakmal Jayasinghe, Domenico Caprotti, Szabolcs Soeroes, Luke McNeill, David Alves, Rebecca Bowen, John Milton
  • Mutant pore
    Patent number: 10975428
    Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 13, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Lakmal Jayasinghe, Elizabeth Jayne Wallace
  • Modified nanopores, compositions comprising the same, and uses thereof
    Patent number: 10976300
    Abstract: Provided herein relate to modified or mutant forms of cytolysin A (ClyA) and compositions comprising the same. In particular, the modified or mutant forms of ClyA permits efficient capture and/or translocation of a target negative-charged molecule or polymer through the modified or mutant ClyA nanopores at low or physiological ionic strengths. Thus, methods for using the modified or mutant forms of ClyA and compositions, for example, for characterizing a target negatively-charged analyte, e.g., a target polynucleotide, are also provided.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 13, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Giovanni Maglia, Lorenzo Franceschini, Tine Brouns, Andrew John Heron, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
  • MODIFIED HELICASES
    Publication number: 20210009971
    Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.
    Type: Application
    Filed: June 4, 2020
    Publication date: January 14, 2021
    Applicant: Oxford Nanopore Technologies Ltd.
    Inventors: Mark Bruce, Andrew John Heron, Ruth Moysey, Szabolcs Soeroes, Elizabeth Jayne Wallace, James White
  • Mutant lysenin pores
    Patent number: 10882889
    Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: January 5, 2021
    Assignee: Oxford Nanopore Technologies Ltd.
    Inventors: Mark Bruce, James Anthony Clarke, Andrew John Heron, Lakmal Jayasinghe, Elizabeth Jayne Wallace