Abstract: A disposable medical introduction system including a medical device and a disposable inserter. The disposable inserter includes a carrier to receive the medical device. The carrier includes at least one annular projection. The disposable inserter includes a retractor received within the at least one annular projection and movable relative to the at least one annular projection. The retractor has at least one retaining arm. The disposable inserter includes a needle cartridge coupled to the retractor that includes an insertion needle. The at least one retaining arm cooperates with the needle cartridge to maintain the insertion needle in a first, extended state. A movement of the retractor relative to the at least one annular projection releases the at least one retaining arm to move the insertion needle from the first, extended state to a second, retracted state.

Abstract: An insertion device configured to implant a first medical device and a second medical device in a user. The first medical device may be a fluid delivery cannula configured to deliver a fluid (e.g., insulin) to the user. The second medical device may be an analyte sensor (e.g., a glucose sensor) configured to detect a physiological characteristic of the user (e.g., a glucose level). The insertion device may be configured to be worn by the user. The insertion device includes a first linkage assembly configured to extend and retract a first insertion needle to implant the first medical device and a second linkage assembly configured to extend and retract a second insertion needle to implant the second medical device. The insertion device includes a user input device configured to cause the insertion device to initiate the implantation when activated by the user.

Abstract: Embodiments of the invention provide multilayer analyte sensors having elements and/or architectures that function to improve oxygen delivery to sensor enzymes in manner that enhances sensor function, as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract: A system for a physiological characteristic sensor deployed with a sensor inserter includes an adhesive skin patch coupled to the physiological characteristic sensor. The adhesive patch is to couple the physiological characteristic sensor to an anatomy. The system also includes a gravity resistance system coupled to the adhesive patch and to be coupled to the sensor inserter. The gravity resistance system maintains the adhesive patch substantially perpendicular to a longitudinal axis of the sensor inserter prior to deployment of the physiological characteristic sensor and is removable from the adhesive patch by the sensor inserter upon deployment of the physiological characteristic sensor.

Abstract: In some examples, a system for monitoring glucose includes processing circuitry and a glucose monitor comprising one or more monitor electrodes and one or more working electrodes, wherein a first chemistry stack is disposed on at least one of the monitor electrode(s) and a second chemistry stack is disposed on at least one of the working electrode(s). The processing circuitry may be configured to measure one or more calibration values of an operating parameter of the monitor electrode(s), retrieve one or more pre-calibration values of the operating parameter of the monitor electrode(s), wherein the pre-calibration value(s) were measured before the calibration value, determine one or more delta values using the calibration value(s) and the pre-calibration value(s), and calibrate glucose values sensed by the working electrode(s) using the delta value(s).

Abstract: A fluid infusion system includes a housing configured to be adhesively coupled to an anatomy of the user. The housing comprises a communication device configured to wirelessly communicate a physiological characteristic to a communication component of a fluid infusion device. The fluid infusion system includes a fluid flow path from the fluid infusion device into the anatomy of the user, and the fluid flow path is configured to extend from the housing for insertion into the anatomy of the user.

Abstract: A medical device includes a base having a needle channel and a first surface configured to be secured to a patient's skin. An insertable member is configured to be secured to the base with a length portion of the insertable member extending out of the needle channel at the first surface, for insertion through the patient's skin at an insertion site. A septum extends across the needle channel. The septum has a body through which an insertion needle may be selectively extended to facilitate the subcutaneous insertion of the length portion of the insertable member. The septum provides a liquid seal across the needle channel. The needle channel and the septum provide a sealed volume in which a limited amount of blood or other fluid from the insertion site may be held.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Abstract: A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.

Abstract: The disclosed system includes a user-mountable electronic device, an output interface, and at least one processor. The electronic device includes a housing and at least one sensor device located within the housing and configured to generate sensor output that indicates orientation or motion of the user-mountable electronic device. The at least one processor is operated to: receive the sensor output; identify, based on the received sensor output, a body part on which the user intends to deploy the user-mountable electronic device; determine a preferred orientation of the user-mountable electronic device relative to the identified body part; and cause the output interface to provide deployment guidance that indicates the preferred orientation of the user-mountable electronic device.

Abstract: Disclosed herein are techniques related to managing dose recommendations in medicine administering systems. The techniques may involve obtaining a recommendation for a dose of medicine to be delivered to a patient and determining that the recommendation is outdated based on detecting one or more intervening events occurring after generation of the recommendation but before any delivery of medicine in accordance with the recommendation. The techniques may further involve implementing one or more safety features for avoiding delivery of the dose of medicine to the patient.

Abstract: Wearable medical devices are provided. An exemplary wearable medical device includes a printed circuit board assembly (PCBA) comprising a dielectric layer having a top surface and conductive features on the top surface of the dielectric layer. Further, the exemplary wearable medical device includes a top housing mounted directly to the top surface of the PCBA. Also, the wearable medical device includes a power source located between the top housing and the PCBA. The top housing and the dielectric layer of the PCBA encapsulates the conductive features and power source and define an outer surface of the wearable medical device.

Abstract: Disclosed herein are techniques related to medicine administration in dynamic networks. The techniques may involve identifying an amount of medicine for delivery to a patient and determining a communication path toward a first medicine administration device of a plurality of medicine administration devices in a mesh network. The plurality of medicine administration devices may further include a second medicine administration device that is prioritized over the first medicine administration device for delivering medicine to the patient. The techniques may further involve causing delivery of the amount of medicine to the patient by the first medicine administration device based on communicating the amount of medicine toward the first medicine administration device via the communication path when the amount of medicine remains undelivered by the second medicine administration device.

Abstract: An accessory for use with a medicine delivery device includes a body configured to attach to a medicine delivery device and a user interface disposed on the body and configured to communicate information to a user. In aspects, the user interface includes first and second lights configured to be selectively illuminated and a first symbol associated with the first light. The first light and the first symbol together indicate an action to be performed when the first light is illuminated. In aspects, the user interface includes red, yellow, and green lights configured to be illuminated in sequential time periods after a dose using the medicine delivery device.

Abstract: An example method for initializing a glucose sensor includes executing an initialization sequence for the glucose sensor, wherein the initialization sequence is based on one or more of parameters related to manufacturing the glucose sensor or environmental conditions of the glucose sensor that are present in vivo, and reporting glucose levels in a patient after the initialization sequence.

Abstract: A medicine injection pen includes a body, a drive member, a cartridge housing, and a medicine cartridge retained within the cartridge housing. The drive member is configured to move relative to the body and the medicine cartridge defines an interior volume configured to retain a liquid medicine. The drive member is configured to translate a piston within the interior volume toward a dispensing end of the medicine cartridge to dispense at least some of the liquid medicine. The medicine cartridge also includes an insertion port configured to receive a medicine dispensing element therethrough for dispensing a liquid medicine into the interior volume to replace at least some of the liquid medicine dispensed through the dispensing end. Dispensing of the liquid medicine into the interior volume of the medicine cartridge applies a fluid pressure to the piston to translate the piston away from the dispensing end of the medicine cartridge.

Abstract: A medicine delivery and tracking system includes a medicine injection pen and a delivery port. The pen includes a needle through which medicine is dispensed and an electronic unit configured to at least one of log dispensing of medicine from the pen, control dispensing of medicine from the pen, or communicate regarding dispensing of medicine from the pen. Alternatively, the electronic unit may be part of a separate computing device. The delivery port is configured for attachment to a user and to receive the needle of the pen such that medicine dispensed from the pen is dispensed into the delivery port and through the delivery port to the user. The delivery port includes a detector mechanism configured to detect a presence of the pen and, in response thereto, to communicate a signal to the electronic unit for use in the at least one of logging, controlling, or communicating.

Abstract: A method for medicine administration and tracking and system for the same that may implement the method via a health management application running on a computing device includes tracking movement of an injection pen from a start location to a dispensing location, detecting a dispensing event of medicine dispensed from the injection pen at the dispensing location, determining a location of the dispensing location relative to a user's body, associating information relating to the detected dispensing event with information relating to the determined location, and providing feedback based upon the detected dispensing event information and the determined location information.

Abstract: A medicine injection pen includes a body, a drive member within the body and configured to move relative thereto upon actuation, a cartridge housing releasably engageable with the body and configured to retain a medicine cartridge, at least one sensor, and at least one detector. The medicine cartridge has a liquid medicine therein and includes a piston configured to slide therein. The drive member is configured to move relative to the body to urge the piston to slide within the medicine cartridge to dispense at least some of the liquid medicine from the medicine cartridge. The sensor(s) is configured to sense movement of the drive member relative to the body to enable determination of an amount of the liquid medicine dispensed. The detector(s) is configured to detect a gap between the drive member and the piston.

Abstract: An apparatus adherable to a user's skin, such as a wearable medical device, is presented here. An embodiment of the apparatus includes a durable component having a periphery defining a footprint of the durable component, and a skin adhesive component coupled to the durable component to facilitate securing the durable component to the user's skin. The skin adhesive component includes a first region and a second region removably attached to the first region. The first region of the skin adhesive component resides completely within the footprint of the durable component. After removal of the second region of the skin adhesive component, the first region remains intact and protected underlying the durable component.