Patents by Inventor Elsebet Ostergaard Nielsen

Elsebet Ostergaard Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20090186880
    Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: May 21, 2007
    Publication date: July 23, 2009
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Ostergaard Nielsen, Daniel B. Timmermann, Steven Charles Loechel, Jeppe Kejser Christensen, Tino Dyhring
  • NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVE AND ITS MEDICAL USE
    Publication number: 20090181984
    Abstract: This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors. Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: May 29, 2007
    Publication date: July 16, 2009
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Ostergaard Nielsen, Daniel B. Timmermann, Steven Charles Loechel
  • Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    Patent number: 7547788
    Abstract: This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: June 16, 2009
    Assignee: NeuroSearch A/S
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Jørgen Scheel-Krüger, Birgitte L. Eriksen
  • Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
    Publication number: 20090137625
    Abstract: This invention relates to novel enantiomers useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: April 6, 2006
    Publication date: May 28, 2009
    Inventors: Dan Peters, Bjarne H. Dahl, Dorthe Filtenborg Olesen, Elsebet Ostergaard Nielsen, Gunnar M. Olsen, John Paul Redrobe
  • Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    Publication number: 20090124663
    Abstract: This invention relates to novel N-phenyl-piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: June 7, 2006
    Publication date: May 14, 2009
    Applicant: NeuroSearch A/S
    Inventors: Dan Peters, John Paul Redrobe, Elsebet Ostergaard Nielsen, David Tristam Brown
  • NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20090118266
    Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: May 29, 2007
    Publication date: May 7, 2009
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Ostergaard Nielsen, Daniel B. Timmermann, Steven Charles Loechel
  • NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONANE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20090118265
    Abstract: This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: May 21, 2007
    Publication date: May 7, 2009
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Ostergaard Nielsen, Daniel B. Timmermann, Steven Charles Loechel, Jeppe Kejser Christensen, Tino Dyhring
  • Novel 3,9-Diaza-Spiro[5,5]Undecane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
    Publication number: 20090111841
    Abstract: This invention relates to novel 3,9-diaza-spiro[5.5]undecane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: June 28, 2006
    Publication date: April 30, 2009
    Inventors: Birgitte L. Eriksen, Dan Peters, Elsebet Ostergaard Nielsen, John Paul Redrobe
  • Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    Patent number: 7524958
    Abstract: This invention relates to novel 9-aza-bicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: April 28, 2009
    Assignee: Neurosearch A/S
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Jørgen Scheel-Krüger
  • Aryl ureido benzoic acid derivatives and their use
    Patent number: 7521480
    Abstract: This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: April 21, 2009
    Assignee: Neurosearch
    Inventors: Jon Valgeirsson, Elsebet Østergaard Nielsen, Dan Peters
  • NOVEL 8,10-DIAZA-BICYCLO[4.3.1]DECANE DERIVATIVES AND THEIR MEDICAL USE
    Publication number: 20090099153
    Abstract: This invention relates to novel 8,10-diaza-bicyclo[4.3.1]decane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: May 21, 2007
    Publication date: April 16, 2009
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Ostergaard Nielsen, Daniel B. Timmermann, Steven Charles Loechel, Jeppe Kejser Christensen, Tino Dyhring
  • Azabicyclic aryl derivatives
    Patent number: 7514450
    Abstract: This invention relates to novel azabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: April 7, 2009
    Assignee: NeuroSearch A/S
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Tino Dyhring Jørgensen, Daniel B. Timmermann
  • Novel Diazabicycloalkane Derivatives and Their Medical Use
    Publication number: 20090075983
    Abstract: This invention relates to novel diaza-bicyclo-alkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Application
    Filed: February 13, 2007
    Publication date: March 19, 2009
    Inventors: Dan Peters, Daniel B. Timmermann, Gunnar M. Olsen, Elsebet Ostergaard Nielsen, Jeppe Kejser Christensen, Tino Dyhring
  • Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex
    Publication number: 20090062304
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: April 18, 2006
    Publication date: March 5, 2009
    Inventors: Lene Teuber, Janus S. Larsen, Philip K. Ahring, Elsebet Ostergaard Nielsen, Naheed Mirza
  • Benzimidazole Derivatives and Their Use for Modulating the GABA-Alpha Receptor Complex
    Publication number: 20090048321
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: December 4, 2006
    Publication date: February 19, 2009
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Ostergaard Nielsen, Naheed Mirza
  • Use of non-competitive and selective GluR5 antagonists as glutamate receptor modulating compounds
    Patent number: 7488756
    Abstract: This invention relates to the use of chemical compounds showing non-competitive and selective GluR5 antagonist or partial agonist activity for treating diseases that are responsive to modulation of an aspartate or a glutamate receptor. Moreover the invention provides chemical compounds for use according to the invention, as well as pharmaceutical compositions comprising the chemical compounds, and methods of treating diseases or disorders or conditions responsive to modulation of an aspartate or a glutamate receptor.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: February 10, 2009
    Assignee: Neurosearch A/S
    Inventors: Dan Peters, Elsebet Østergaard Nielsen, Alex Haahr Gouliaev
  • Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex
    Publication number: 20090036493
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: April 7, 2006
    Publication date: February 5, 2009
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Ostergaard Nielsen, Naheed Mirza
  • Novel 3-Aza-Spiro[5,5]Undec-8-Ene Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
    Publication number: 20090036477
    Abstract: This invention relates to novel 3-aza-spiro[5.5]undec-8-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: June 28, 2006
    Publication date: February 5, 2009
    Inventors: Birgitte L. Eriksen, Dan Peters, Elsebet Ostergaard Nielsen, John Paul Redrobe
  • 3,9-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
    Publication number: 20090036456
    Abstract: This invention relates to novel 3,9-diazabicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Application
    Filed: February 9, 2007
    Publication date: February 5, 2009
    Inventors: Dan Peters, John Paul Redrobe, Elsebet Ostergaard Nielsen
  • BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
    Publication number: 20090036476
    Abstract: This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
    Type: Application
    Filed: March 22, 2007
    Publication date: February 5, 2009
    Inventors: Janus S. Larsen, Lene Teuber, Philip K. Ahring, Elsebet Ostergaard Nielsen, Naheed Mirza