Patents by Inventor Emanuele Attolino

Emanuele Attolino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE PREPARATION OF TRIS-(3-HYDROXYBUTYRATO)-GLYCERYL ESTER
    Publication number: 20240092723
    Abstract: The present invention concerns a method to prepare and purify the ester glyceryl-tris-(3-hydroxy butyrate) of formula (I) and its optically active isomers, in particular the enantiomer (R, R, R).
    Type: Application
    Filed: October 6, 2020
    Publication date: March 21, 2024
    Applicant: DR. SCHAR S.P.A.
    Inventors: Virna Lucia Cerne, Gabriele Razzetti, Simone Mantegazza, Roberto Rossi, Philippe Carboni, Niccolo Santillo, Davide Brenna, Emanuele Attolino
  • METHOD TO PURIFY TRIS-(3-HYDROXYBUTYRATO)-GLYCERYL ESTER
    Publication number: 20230147401
    Abstract: The present invention concerns a method to prepare and purify the ester glyceryl-tris-(3-hydroxybutyrate) of formula (I): and its optically active isomers, in particular the enantiomer (R, R, R).
    Type: Application
    Filed: October 6, 2020
    Publication date: May 11, 2023
    Applicant: DR. SCHAR S.P.A.
    Inventors: Virna Lucia Cerne, Gabriele Razzetti, Simone Mantegazza, Roberto Rossi, Philippe Carboni, Niccolo Santillo, Davide Brenna, Emanuele Attolino
  • Synthesis of an azasugar and intermediates thereof
    Patent number: 11180454
    Abstract: The present invention relates to a process for the preparation of migalastat of formula (I) and intermediates useful in the synthesis thereof. The process comprises the double reductive amination reaction of a compound of formula (VI).
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: November 23, 2021
    Assignee: DIPHARMA SA
    Inventors: Emanuele Attolino, Niccolo Santillo, Gabriele Razzetti
  • METHOD FOR PREPARING A FARNESOID X RECEPTOR AGONIST
    Publication number: 20200339622
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Application
    Filed: July 15, 2020
    Publication date: October 29, 2020
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Anna IULIANO, Luca GIANNOTTI, Grazia IANNUCCI, Emanuele ATTOLINO, Vittorio LUCCHINI, Renzo GRAZIOSI
  • Method for preparing a farnesoid X receptor agonist
    Patent number: 10752654
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: August 25, 2020
    Assignee: Dipharma Francis S.R.L.
    Inventors: Gabriele Razzetti, Anna Iuliano, Luca Giannotti, Grazia Iannucci, Emanuele Attolino, Vittorio Lucchini, Renzo Graziosi
  • SYNTHESIS OF AN AZASUGAR AND INTERMEDIATES THEREOF
    Publication number: 20200216393
    Abstract: The present invention relates to a process for the preparation of migalastat of formula (I) and intermediates useful in the synthesis thereof. The process comprises the reductive amination reaction of a compound of formula (VI).
    Type: Application
    Filed: July 10, 2018
    Publication date: July 9, 2020
    Inventors: Emanuele Attolino, Niccolo Santillo, Gabriele Razzetti
  • Intermediates and process for the preparation of a crystalline form of a topical anti-inflammatory agent
    Patent number: 10597410
    Abstract: The present invention relates to a process for the preparation of an inhibitor of phosphodiesterase 4, in particular of phosphodiesterase 4B (PDE4B), and intermediates useful for its preparation.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: March 24, 2020
    Assignee: DIPHARMA FRANCIS S.R.L.
    Inventors: Niccolo′ Santillo, Emanuele Attolino, Davide Brenna, Chiara Vladiskovic, Alessandro Lombardo, Gabriele Razzetti
  • INTERMEDIATES AND PROCESS FOR THE PREPARATION OF A CRYSTALLINE FORM OF A TOPICAL ANTI-INFLAMMATORY AGENT
    Publication number: 20190241585
    Abstract: The present invention relates to a process for the preparation of an inhibitor of phosphodiesterase 4, in particular of phosphodiesterase 4B (PDE4B), and intermediates useful for its preparation.
    Type: Application
    Filed: January 24, 2019
    Publication date: August 8, 2019
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Niccolo' Santillo, Emanuele Attolino, Davide Brenna, Chiara Vladiskovic, Alessandro Lombardo, Gabriele Razzetti
  • METHOD FOR PREPARING A FARNESOID X RECEPTOR AGONIST
    Publication number: 20190106455
    Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
    Type: Application
    Filed: April 3, 2017
    Publication date: April 11, 2019
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Anna IULIANO, Luca GIANNOTTI, Grazia IANNUCCI, Emanuele ATTOLINO, Vittorio LUCCHINI, Renzo GRAZIOSI
  • Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase
    Patent number: 10093610
    Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: October 9, 2018
    Assignee: DIPHARMA S.A.
    Inventor: Emanuele Attolino
  • Crystalline Inhibitor of 4-Hydroxyphenylpyruvate Dioxygenase
    Publication number: 20180148402
    Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.
    Type: Application
    Filed: September 14, 2017
    Publication date: May 31, 2018
    Applicant: Dipharma S.A.
    Inventor: Emanuele ATTOLINO
  • Process for the preparation of piperidine compounds
    Patent number: 9932321
    Abstract: The present invention relates to a process for the preparation of efinaconazole.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: April 3, 2018
    Assignee: Dipharma Francis S.R.L.
    Inventors: Emanuele Attolino, Davide Rossi, Gabriele Razzetti
  • METHOD FOR PREPARING AN ANTIFIBROTIC AGENT
    Publication number: 20180009753
    Abstract: The present invention relates to a process for the preparation of pirfenidone, an immunosuppressive drug developed for the treatment of idiopathic pulmonary fibrosis.
    Type: Application
    Filed: July 5, 2017
    Publication date: January 11, 2018
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Gabriele RAZZETTI, Emanuele ATTOLINO, Mauro MITTINO, Alessandro LOMBARDO, Alessandro RESTELLI
  • Crystalline inhibitor of 4-hydroxyphenylpyruvate dioxygenase, and a process of synthesis and crystallization thereof
    Patent number: 9783485
    Abstract: The present invention relates to an improved synthesis and crystallization process of the 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, also known as nitisinone or NTBC.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: October 10, 2017
    Assignee: Dipharma S.A.
    Inventor: Emanuele Attolino
  • Antimuscarinic compound having a low content of impurities
    Patent number: 9751828
    Abstract: Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: September 5, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Pietro Allegrini, Emanuele Attolino, Renzo Graziosi
  • Synthesis of an azasugar and the intermediates thereof
    Patent number: 9708263
    Abstract: Process for the preparation of intermediates useful in the synthesis of miglustat and their use in its manufacture.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: July 18, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Andrea Malvestiti, Enrico Brunoldi, Emanuele Attolino
  • Process for the preparation of an antidepressant and the intermediates thereof
    Patent number: 9550743
    Abstract: The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: January 24, 2017
    Assignee: Dipharma Francis S.r.l.
    Inventors: Luca Giannotti, Renzo Graziosi, Emanuele Attolino, Pietro Allegrini
  • PROCESS FOR THE PREPARATION OF PIPERIDINE COMPOUNDS
    Publication number: 20160376253
    Abstract: The present invention relates to a process for the preparation of efinaconazole.
    Type: Application
    Filed: June 28, 2016
    Publication date: December 29, 2016
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Emanuele Attolino, Davide Rossi, Gabriele Razzetti
  • SYNTHESIS OF AN AZASUGAR AND THE INTERMEDIATES THEREOF
    Publication number: 20160304458
    Abstract: Process for the preparation of intermediates useful in the synthesis of miglustat and their use in its manufacture.
    Type: Application
    Filed: April 14, 2016
    Publication date: October 20, 2016
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Andrea MALVESTITI, Enrico BRUNOLDI, Emanuele ATTOLINO
  • PROCESS FOR THE PREPARATION OF AN ANTIDEPRESSANT AND THE INTERMEDIATES THEREOF
    Publication number: 20160145224
    Abstract: The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
    Type: Application
    Filed: November 19, 2015
    Publication date: May 26, 2016
    Applicant: DIPHARMA FRANCIS s.r.l.
    Inventors: Luca GIANNOTTI, Renzo GRAZIOSI, Emanuele ATTOLINO, Pietro ALLEGRINI