Patents by Inventor Emanuele Attolino

Emanuele Attolino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIMUSCARINIC COMPOUND HAVING A LOW CONTENT OF IMPURITIES
    Publication number: 20160031796
    Abstract: Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
    Type: Application
    Filed: June 23, 2015
    Publication date: February 4, 2016
    Applicant: Dipharma Francis S.r.l.
    Inventors: Pietro ALLEGRINI, Emanuele ATTOLINO, Renzo GRAZIOSI
  • Synthesis of a glycosyltransferase inhibitor
    Patent number: 9079856
    Abstract: Process for the preparation of an iminosugar, and the intermediates thereof, having known activity as a glycosyltransferase inhibitor and used, for example, in the treatment of Gaucher's disease.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: July 14, 2015
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Andrea Malvestiti
  • CRYSTALLINE FORMS OF AN ADRENERGIC AGONIST
    Publication number: 20150111934
    Abstract: The present invention relates to the acetate salt of Mirabegron, in particular in two novel crystalline forms, a process for their preparation and the use of said salt and its crystalline forms in the synthesis of Mirabegron with high yields and chemical purity.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 23, 2015
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Alessio BOVE, Pietro ALLEGRINI, Emanuele ATTOLINO
  • Apixaban preparation process
    Patent number: 8969561
    Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: March 3, 2015
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Alessandro Lombardo, Simone Tambini
  • APIXABAN PREPARATION PROCESS
    Publication number: 20150025242
    Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 22, 2015
    Applicant: DIPHARMA FRANCIS S.r.l.
    Inventors: Emanuele ATTOLINO, Alessandro LOMBARDO, Simone TAMBINI
  • PROCESS FOR THE PREPARATION OF A VIRAL PROTEASE INHIBITOR AND INTERMEDIATES THEREOF
    Publication number: 20140323689
    Abstract: Process for the preparation of a viral protease inhibitor and intermediates useful in its preparation.
    Type: Application
    Filed: April 21, 2014
    Publication date: October 30, 2014
    Applicant: DIPHARMA FRANCIS S.r.I.
    Inventors: Anna IULIANO, Varsha Ravindra JUMDE, Emanuele ATTOLINO, Maurizio TADDEI
  • PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATES
    Publication number: 20140309437
    Abstract: Process for the preparation of intermediates that are useful in the synthesis of active pharmaceutical ingredients (API), in particular active in the central nervous system.
    Type: Application
    Filed: April 8, 2014
    Publication date: October 16, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Marco ARTICO, Emanuele ATTOLINO
  • PROCESS FOR THE PREPARATION OF FESOTERODINE OR A SALT THEREOF
    Publication number: 20140275610
    Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities.
    Type: Application
    Filed: June 2, 2014
    Publication date: September 18, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Marco ARTICO, Emanuele ATTOLINO, Pietro ALLEGRINI, Gabriele RAZZETTI
  • SYNTHESIS OF A SEROTONIN REUPTAKE INHIBITOR
    Publication number: 20140275542
    Abstract: Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Maurizio TADDEI, Luca GIANNOTTI, Emanuele ATTOLINO, Pietro ALLEGRINI
  • SYNTHESIS OF A GLYCOSYLTRANSFERASE INHIBITOR
    Publication number: 20140243369
    Abstract: Process for the preparation of animinosugar, and the intermediates thereof, having known activity as a glycosyltransferase inhibitor and used, for example, in the treatment of Gaucher's disease.
    Type: Application
    Filed: December 5, 2013
    Publication date: August 28, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Emanuele ATTOLINO, Andrea MALVESTITI
  • Process for the preparation of pteridine derivatives
    Patent number: 8809553
    Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: August 19, 2014
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini
  • Iminosugar in crystalline form
    Patent number: 8802155
    Abstract: Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: August 12, 2014
    Assignee: Dipharma Francis S.r.l.
    Inventors: Emanuele Attolino, Andrea Malvestiti
  • IMINOSUGAR IN CRYSTALLINE FORM
    Publication number: 20140205666
    Abstract: Iminosugar, which possesses known activity as a glycosyltransferase inhibitor, and is used, for example, in the treatment of Gaucher's disease, in crystalline form, a process for its preparation and a pharmaceutical composition thereof.
    Type: Application
    Filed: January 7, 2014
    Publication date: July 24, 2014
    Applicant: DIPHARMA FRANCIS S.r.I.
    Inventors: Emanuele ATTOLINO, Andrea MALVESTITI
  • Process for the preparation of fesoterodine or a salt thereof
    Patent number: 8772340
    Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: July 8, 2014
    Assignee: Dipharma Francis S.r.l.
    Inventors: Marco Artico, Emanuele Attolino, Pietro Allegrini, Gabriele Razzetti
  • PROCESS FOR THE PREPARATION OF AN ANTICONVULSANT COMPOUND
    Publication number: 20140163252
    Abstract: The invention provides a novel method for the preparation of intermediates useful in a process designed to obtain known 1,2,4-triaminobenzene compounds, and in particular a specific compound thereof having known anticonvulsant activity. Unlike known methods, the novel method does not require advance protection of the amino groups present on the substrate.
    Type: Application
    Filed: October 29, 2013
    Publication date: June 12, 2014
    Applicant: DIPHARMA FRANCIS S.r.I
    Inventors: Emanuele ATTOLINO, Roberto ROSSI, Marco ARTICO
  • SYNTHESIS OF AN INTERMEDIATE OF AN ANTIVIRAL COMPOUND
    Publication number: 20140148574
    Abstract: Process for the preparation of a cyclopropylamide compound which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.
    Type: Application
    Filed: November 22, 2013
    Publication date: May 29, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Pietro ALLEGRINI, Enrico BRUNOLDI, Emanuele ATTOLINO, Alessio BOVE
  • APIXABAN PREPARATION PROCESS
    Publication number: 20140058107
    Abstract: Process for the preparation of apixaban and intermediates useful for the preparation thereof.
    Type: Application
    Filed: June 7, 2012
    Publication date: February 27, 2014
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Chiara Vladiskovic, Emanuele Attolino, Alessandro Lombardo, Simone Tambini
  • Process for the preparation of fesoterodine
    Patent number: 8530691
    Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine), its (S)-enantiomer, and novel intermediates useful in the synthesis.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: September 10, 2013
    Assignee: Dipharma Francis s.r.l.
    Inventors: Simone Mantegazza, Pietro Allegrini, Emanuele Attolino
  • Process for the preparation of fesoterodine with low impurities content
    Patent number: 8455678
    Abstract: Disclosed is a process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having a low content of impurities such as tolterodine and tolterodine isobutyrate.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: June 4, 2013
    Assignee: Dipharma Francis s.r.l.
    Inventors: Marco Artico, Emanuele Attolino, Pietro Allegrini
  • PROCESS FOR THE PREPARATION OF PTERIDINE DERIVATIVES
    Publication number: 20130090474
    Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.
    Type: Application
    Filed: June 13, 2011
    Publication date: April 11, 2013
    Applicant: DIPHARMA FRANCIS S.R.L.
    Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini