Patents by Inventor Emil P. Kartalov

Emil P. Kartalov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9037209
    Abstract: An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: May 19, 2015
    Assignees: SANOFI, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Axel Scherer, Remi Brouard, III, Emil P. Kartalov, Jingqing Huang
  • Patent number: 9005987
    Abstract: Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: April 14, 2015
    Assignees: University of Southern California, California Institute of Technology
    Inventors: Emil P. Kartalov, Axel Scherer, Clive R. Taylor
  • Publication number: 20150038379
    Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.
    Type: Application
    Filed: October 10, 2014
    Publication date: February 5, 2015
    Inventors: Emil P. KARTALOV, Darryl SHIBATA, Clive TAYLOR, Lawrence A. WADE
  • Patent number: 8889416
    Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: November 18, 2014
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Emil P. Kartalov, Darryl Shibata, Clive Taylor, Lawrence A. Wade
  • Publication number: 20140100102
    Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device comprises strips of centrifuge tubes and elements to create a magnetic field. The magnetic shear forces applied to beads inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.
    Type: Application
    Filed: October 8, 2013
    Publication date: April 10, 2014
    Applicant: California Institute Of Technology
    Inventors: Aditya RAJAGOPAL, Emil P. KARTALOV, Carl J. ALLENDORPH, Axel SCHERER, Samson CHEN
  • Publication number: 20130267005
    Abstract: A microfluidic fluid separator for separating target components of a fluid by filtration is described. Methods for separating target components of a fluid by filtration and methods for processing blood on a large scale with the microfluidic fluid separator are provided.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 10, 2013
    Inventors: Emil P. KARTALOV, Axel SCHERER, Koichi SAYANO
  • Patent number: 8480978
    Abstract: A microfluidic fluid separator for separating target components of a fluid by filtration is described. Methods for separating target components of a fluid by filtration and methods for processing blood on a large scale with the microfluidic fluid separator are provided.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: July 9, 2013
    Assignees: University of Southern California, APIC Corporation, California Institute of Technology
    Inventors: Emil P. Kartalov, Axel Scherer, Koichi Sayano
  • Patent number: 8424560
    Abstract: Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: April 23, 2013
    Assignees: University of Southern California, California Institute of Technology
    Inventors: Emil P. Kartalov, John Liu, Axel Scherer, Clive Taylor
  • Patent number: 8361738
    Abstract: Described herein is a method for detection of a target in a sample and related devices and systems.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: January 29, 2013
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Emil P. Kartalov, Axel Scherer, Clive Taylor
  • Publication number: 20120085648
    Abstract: A microfluidic fluid separator for separating target components of a fluid by filtration is described. Methods for separating target components of a fluid by filtration and methods for processing blood on a large scale with the microfluidic fluid separator are provided.
    Type: Application
    Filed: August 9, 2011
    Publication date: April 12, 2012
    Inventors: Emil P. KARTALOV, Axel Scherer, Koichi SAYANO
  • Publication number: 20110287959
    Abstract: The present invention includes methods, assays, and devices for assaying a sample to detect the presence, absence, or level of at least one analyte in a biological sample using a pan-antibody panel or multiplexed immunoassay, wherein at least one analyte is detected by two or more antibodies. Certain embodiments include the use of a microfluidic device in the immunoassay. Further embodiments of the invention include assays, methods, and devices to detect the presence, absence, or level of at least one analyte which is determined for a diagnostic or a scientific purpose. Still further embodiments of the invention include assays, methods, and devices to detect the presence, absence, or level of at least one analyte which is indicative of a condition or disease. Yet further embodiments of the invention include incorporating additional diagnostic techniques (e.g., PCR, RT-PCR, and DNA hybridization arrays) to the assays, device, and methods.
    Type: Application
    Filed: May 20, 2011
    Publication date: November 24, 2011
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Jane F. Emerson, Emil P. Kartalov
  • Publication number: 20110275544
    Abstract: The present invention describes microfluidics being employed to achieve multiplex surface functionalization of nanosensor chips by selectively delivering probe molecules to individual nanosensors in an array, and microfluidics being employed to achieve delivery of a solution containing multiple analytes over individual nanosensors in an array, where each nanosensor was previously configured with a specific capture molecule.
    Type: Application
    Filed: October 1, 2008
    Publication date: November 10, 2011
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Chongwu Zhou, Mark E. Thompson, Richard James Cote, Emil P. Kartalov
  • Publication number: 20110177518
    Abstract: Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device.
    Type: Application
    Filed: January 20, 2011
    Publication date: July 21, 2011
    Inventors: Emil P. Kartalov, Darryl Shibata, Clive Taylor, Lawrence A. Wade
  • Publication number: 20100267064
    Abstract: Described herein is a method for detection of a target in a sample and related devices and systems.
    Type: Application
    Filed: March 4, 2010
    Publication date: October 21, 2010
    Inventors: Emil P. Kartalov, Axel Scherer, Clive Taylor
  • Publication number: 20100267162
    Abstract: Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
    Type: Application
    Filed: April 15, 2010
    Publication date: October 21, 2010
    Inventors: Emil P. KARTALOV, Axel Scherer, Clive R. Taylor
  • Publication number: 20100186840
    Abstract: Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.
    Type: Application
    Filed: December 11, 2009
    Publication date: July 29, 2010
    Inventors: Emil P. KARTALOV, John LIU, Axel SCHERER, Clive R. TAYLOR
  • Publication number: 20080253930
    Abstract: Tubes and connectors for microfluidic devices are described. The tubes are provided with a coding on their external surface for example, to allow easier identification. The connector comprises a plurality of through holes going through the connector. Each through hole can accommodate a pin for connection of microfluidic device ports on one side of the pin and connection of a reagent or sample liquid tube on the other side of the pin.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 16, 2008
    Inventors: Emil P. Kartalov, Carl L. Hansen, Stephen R. Quake