Abstract: This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.

Abstract: Disclosed embodiments are directed at systems, methods, and architecture for providing execution order and execution for plugins installed on an API gateway associated with a microservices application. In application architectures where features of microservices are implemented as plugins and migrated to an API gateway, the relevant APIs are able to be built lighter weight than otherwise. However, the migration of the features to plugins introduces the potential for error states in the microservice application. To resolve the potential issues, the API gateway takes into consideration a set of native instructions in each of the plugins to determine the execution order thereof. The execution order is determined dynamically in response to requests by the APIs of the microservice application.

Abstract: A method includes providing steam to the solid oxide fuel cell stack, splitting exhaust gas from the cell stack into two portions, a first portion directed to a superheater and a second portion directed to an ejector and to a hydrogen separator. At least part of the first portion of the exhaust gas that is directed to the superheater is subsequently boiled in a boiler and then returned to the superheater. After being returned to the superheater, this part is directed to the ejector as high pressure steam so as to drive the ejector.

Abstract: The present invention describes fusion proteins based on cytokines, called bi-cytokines (BC), specifically formed by the binding of an IL2 agonist mutein with a type I interferon (IFN), linked by an Fc region of a mutant human IgG1 and a connector peptide. The combination of an IL2 agonist mutein and a type I IFN in the structure of the bi-cytokines gives surprising immunoregulatory properties to these molecules and a superior therapeutic effect than that of parental cytokines, or their combination, which makes them attractive and novel molecules for the treatment of cancer. Pharmaceutical compositions comprising as an active ingredient the fusion proteins object of this patent are also described.

Abstract: A ultra-wideband interconnection probe (100) connectable to a first access port of a first electronic device (101), the first access port comprising a first tapered coupler (101a) and to a second access port of a second electronic device (102), the second access port comprising a second tapered coupler (102a), the ultra-wideband interconnection probe (100) comprising a dielectric waveguide structure (120) establishing a high-pass characteristic interconnect, operating over a high frequency range starting from a low cut-off frequency fa in the microwave range or in the millimeter-wave range, wherein the dielectric waveguide structure (120) comprises a first tapered end (120a) connectable to the first access port via the first tapered coupler (101a) and a second tapered end (120b) connectable to the second access port via the second tapered coupler (102a).

Abstract: Disclosed embodiments are directed at systems, methods, and architecture for operating a control plane of a microservice architecture application. The control plane may link a plurality of APIs for the microservice architecture application. The communication between the APIs and the control plane enables the control plane to assess the settings of the APIs compared to stored versions of the settings. The settings and stored versions may each be hashed with a hashing algorithm. The control plane may instruct APIS to update their settings responsive to determining that the settings do not match the stored versions.

Abstract: Disclosed embodiments are directed at systems, methods, and architecture for providing execution order and execution for plugins installed on an API gateway associated with a microservices application. In application architectures where features of microservices are implemented as plugins and migrated to an API gateway, the relevant APIs are able to be built lighter weight than otherwise. However, the migration of the features to plugins introduces the potential for error states in the microservice application. To resolve the potential issues, the API gateway takes into consideration a set of native instructions in each of the plugins to determine the execution order thereof. The execution order is determined dynamically in response to requests by the APIs of the microservice application.

Abstract: Grouping vectors describing functional interactions between compounds and reagents into clusters identifies groups of similar compounds, and may identify drug targets, pathways of action, deleterious toxicities, immune stimulation and evasion potential, or other information regarding interactions between compounds and reagents.

Abstract: Disclosed embodiments are directed at systems, methods, and architecture for operating a control plane of a microservice architecture application. The control plane may links a plurality of APIs for the microservice architecture application. The communication between the APIs and the control plane enables the control plane to assess the settings of the APIs compared to stored versions of the settings. The settings and stored versions may each be hashed with a hashing algorithm. The control plane may instruct APIS to update their settings responsive to determining that the settings do not match the stored versions.

Abstract: A protective housing for a central electrical system deployed within an electric vehicle is described. The protective housing features a first housing layer, a second housing layer and a third housing layer. The first housing layer is configured to support and protect one or more power distribution units responsible for distributing high-voltage power to components within the electric vehicle. The second housing layer is positioned above the first housing layer, where the second housing layer is to support and protect a power charger that disseminates supplied input power to a high-voltage junction box for routing to the battery system of the vehicle. The third housing layer is positioned above the second housing layer, where the third housing layer is to support a high-voltage junction box that handles the routing of power between the distribution unit(s), the charger and the battery system.

Abstract: An assembly having an aircraft door and auxiliary equipment. The aircraft door and the auxiliary equipment are connected by a flexible deformable bellows having creases. The door comprises a passing through hole and a support joinable to the first end of the bellows. The auxiliary equipment comprises a support joinable to the second end of the bellows and a projecting part. The projecting part is configured to have elevation movement and/or azimuth movement, and the projecting part crosses the interior of the bellows and the hole of the door and protrudes out of the door. At both ends of the bellows a clamp joins and tightens each end of the bellows with the corresponding support. There is a fixed joint between the first end of the bellows and the door and a movable joint between the second end of the bellows and the auxiliary equipment.

Abstract: Disclosed embodiments are directed at systems, methods, and architecture for operating a control plane of a microservice architecture application. The control plane may links a plurality of APIs for the microservice architecture application. The communication between the APIs and the control plane enables the control plane to assess the settings of the APIs compared to stored versions of the settings. The settings and stored versions may each be hashed with a hashing algorithm. The control plane may instruct APIS to update their settings responsive to determining that the settings do not match the stored versions.

Abstract: Disclosed embodiments are directed at systems, methods, and architecture for providing execution order and execution for plugins installed on an API gateway associated with a microservices application. In application architectures where features of microservices are implemented as plugins and migrated to an API gateway, the relevant APIs are able to be built lighter weight than otherwise. However, the migration of the features to plugins introduces the potential for error states in the microservice application. To resolve the potential issues, the API gateway takes into consideration a set of native instructions in each of the plugins to determine the execution order thereof. The execution order is determined dynamically in response to requests by the APIs of the microservice application.

Abstract: A horseshoe-shaped guide catheter for stent angioplasty of the ductus arteriosus in newborn and infants with ductal-dependent cardiopathies, characterized by a long, straight, hollow first section merged at the distal end thereof to a second section formed by a curved portion shaped as a circle section with radius (Ra) of 7.5 mm to 9 mm, arc (b) of 180° to 280° and distance (d) between the tip of the second section and the straight part of the first section without deformations of 7 mm and 15 mm. The angioplasty makes it possible to insert one or more stents that keep the ductus open in extrauterine life, improving survival of the newborn and young infants, allowing weight gain and undergo corrective surgery a few months later with safer and with better outcomes.

Abstract: It is disclosed a method and a predicting system for automatic prediction of porosity appearance generated during Laser Powder Bed Fusion (L-PBF), performed by an additive manufacturing system from at least one material. The method comprises steps for training a neural network comprising: generating labels of pore in every pixel using a porosity simulator; pre-training, comprising a first sub-step and a second sub-step, the second sub-step comprises using the data set created from the first sub-step to generate a pre-trained ML model; and training, comprising a first sub-step and a second sub-step, the second sub-step comprises using the data set created from the first sub-step to train the pre-trained ML model to generate a trained ML model.

Abstract: An assembly comprising an aircraft door and auxiliary equipment. The aircraft door and the auxiliary equipment are connected by a flexible deformable bellows comprising creases. The door comprises a passing through hole and a support joinable to the first end of the bellows. The auxiliary equipment comprises a support joinable to the second end of the bellows and a projecting part. The projecting part is configured to have elevation movement and/or azimuth movement, and the projecting part crosses the interior of the bellows and the hole of the door and protrudes out of the door. At both ends of the bellows a clamp joins and tightens each end of the bellows with the corresponding support. There is a fixed joint between the first end of the bellows and the door and a movable joint between the second end of the bellows and the auxiliary equipment.

Abstract: A horseshoe-shaped guide catheter for stent angioplasty of the ductus arteriosus in newborn and infants with ductal-dependent cardiopathies, characterized by a long, straight, hollow first section merged at the distal end thereof to a second section formed by a curved portion shaped as a circle section with radius (Ra) of 7.5 mm to 9 mm, arc (b) of 180° to 280° and distance (d) between the tip of the second section and the straight part of the first section without deformations of 7 mm and 15 mm. The angioplasty makes it possible to insert one or more stents that keep the ductus open in extrauterine life, improving survival of the newborn and young infants, allowing weight gain and undergo corrective surgery a few months later with safer and with better outcomes.

Abstract: The present invention includes compound and methods that are useful in treating certain cancers, such as synovial sarcomas.

Abstract: The present invention includes compound and methods that are useful in treating certain cancers, such as synovial sarcomas.

Abstract: Method, system and computer program for measuring light diffusion in the eyeball or in the ocular region. The method comprises: projecting a punctiform light beam onto the retina; correcting low-order ocular aberrations of the eye; capturing and recording an image of the retinal plane formed after reflection of the punctiform light beam on the retina and a double passage through the ocular media of the eye; and at the same time as capturing the image of the retinal plane, performing a high- and low-order ocular aberration measurement in the plane of the pupil and performing a light diffusion measurement, combining ocular aberration measurement information with information on the image of the retinal plane. The system and the computer program are adapted for implementing the method.