Abstract: This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) of Neisseria meningitidis in solutions containing fully synthetic variants of the GM3 ganglioside.

Abstract: The present invention is related to the use of ethylene alkanoate-alkyl acrylate bipolymers with a high randomness monomers distribution, which are synthesized by semicontinuous emulsion polymerization process, characterized because it is carried out using slow addition rate of the pre-emulsion feeding ({dot over (q)}?0.009 kgL·L?1·min?1), stabilized this last one by alkyl glycol ether type surfactants, at temperatures higher than 75° C. and with solids contents above 25 wt %, which avoids the formation of large sequences (blocks) of a same monomer. This structural characteristic gives the ethylene alkanoate-alkyl acrylate bipolymers a high efficiency as chemical agents for removal of complex water/crude oil emulsions of crude oil blends.

Abstract: A method for treating and controlling physiological disorders that are caused during the post-harvest process of fruit, which includes the application of an aqueous solution which is an edible coating. The coating includes at least one phospholipid, or at least one polysorbate, or at least a sorbitan ester, or at least a sucrose ester of fatty acids or at least a sucroglyceride of fatty acids or a combination thereof, the application being during any one of the stages of the post-harvest process to their shipment and sale at their final destination.

Abstract: A nozzle to output air onto an interior surface of a windshield of a vehicle is includes: a housing including: a first opening configured to receive air output by a blower; a second opening to output air toward the interior surface of the windshield; N sets of tracks formed in the housing, where N is an integer greater than 1; N vanes that are flexible and that each slide along a respective one of the N sets of tracks; and an actuator that is coupled to each of the N vanes and that is configured to slide along the N vanes along the N sets of tracks, respectively.

Abstract: The present invention corresponds to a full-face respiratory mask that prevents the entry and exit of particles during the breathing process. The mask has a hermetic seal against the skin that does not allow particles found in the environment to pass through and a single opening that is also hermetically sealed, this opening is coupled with the outer filter and is where the filtered air enters and exits.

Abstract: The invention relates to a process for the preparation of compounds of formula (I), which are useful intermediates in the synthesis of Upadacitinib and structurally related compounds, by using Weinreb amide (III), or an equivalent thereof, as key intermediate.

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses a molecule having the following formula.

Abstract: A lithium ion conductive solid electrolyte contains a lithium ion conductive powder having a garnet-type crystal structure including at least Li, La, Zr, and O, and a lithium ion conductive polymer. The lithium ion conductive solid electrolyte can maintain its shape without use of an additional polymer different from the lithium ion conductive polymer. The lithium ion conductive solid electrolyte exhibits an activation energy of 30 kJ/mol or less at 20° C. to 80° C.

Abstract: A nozzle to output air onto an interior surface of a windshield of a vehicle is includes: a housing including: a first opening configured to receive air output by a blower; a second opening to output air toward the interior surface of the windshield; N sets of tracks formed in the housing, where N is an integer greater than 1; N vanes that are flexible and that each slide along a respective one of the N sets of tracks; and an actuator that is coupled to each of the N vanes and that is configured to slide along the N vanes along the N sets of tracks, respectively.

Abstract: Highly dense lithium based ceramics can be prepared by a low temperature process including combining a lithium based ceramic with a polar solvent having a lithium based salt dissolved therein and applying pressure and heat to the combination to form a salt-ceramic composite. Advantageously, the lithium salt is one that dissolves in the polar solvent and the heat applied to the combination is no greater than about 250° C. Such composites can also have high ionic conductivity.

Abstract: A machine-learning tool learns from sensors' data of a nuclear reactor at steady state and maps them to controls of the nuclear reactor. The tool learns all given ranges of normal operation and responses for corrective measures. The tool may train another learning tool (or the same tool) that forecasts the behavior of the reactor based on real-time changes (e.g., every 10 seconds). The tool implements an optimization technique for differing half-life materials to be placed in the reactor. The tool maximizes isotope production based on optimal controls of the reactor.

Abstract: The present invention describes the method for treating and controlling physiological disorders that are caused during the post-harvest process of fruit, which comprises the application of an aqueous solution which is a edible coating and said coating comprising at least one phospholipid, or at least one polysorbate, or at least a sorbitan ester, or at least a sucrose ester of fatty acids or at least a sucroglyceride of fatty acids or a combination thereof the application being during any one of the stages of the post-harvest process to their shipment and sale at their final destination.

Abstract: The present invention relates to the use of levels of the amount or concentration of the ghrelin-O-acyltransferase (GOAT) enzyme or of the mRNA encoding this protein, obtained ex vivo from a biological sample isolated from a subject, as an efficient tool for obtaining data that can be used in the clinical diagnosis of prostate cancer.

Abstract: Highly dense lithium based ceramics can be prepared by a low temperature process including combining a lithium based ceramic with a polar solvent having a lithium based salt dissolved therein and applying pressure and heat to the combination to form a salt-ceramic composite. Advantageously, the lithium salt is one that dissolves in the polar solvent and the heat applied to the combination is no greater than about 250° C. Such composites can also have high ionic conductivity.

Abstract: The present invention relates to a diagnostic and/or prognostic method for the diagnosis and/or prognosis of cancer in a patient. Particularly, the present invention relates to diagnostic and/or prognostic methods for the diagnosis and/or prognosis of cancer which comprise quantifying the expression levels of In1-ghrelin in a plasma sample isolated from an individual; comparing the obtained levels with the expression levels of In1-ghrelin in a reference sample; and assigning the patients having expression levels of In1-ghrelin that are greater than and statistically significant with respect to the levels of the reference sample to the group of individuals at risk of having cancer. The present invention also provides a diagnostic method for the diagnosis of bladder and/or colon cancer which comprises quantifying the expression levels of In1-ghrelin, GOAT and/or GHS-R1b in tissue samples. The present invention also relates to an siRNA useful in a cancer treatment method.

Abstract: An insect control formulation including methyl eugenol, cue lure and a biodegradable wax carrier is a surprisingly effective attractant for Oriental fruit flies (Bactrocera dorsalis) and Melon flies (Bactrocera cucurbitae). Formulation embodiments that include at least one insect toxicant are surprisingly effective for use in fruit fly MAT attract and kill systems, and are suitable for on-crop or off-crop uses. Formulation embodiments can be provided as aqueous emulsions having viscosities appropriate for use in aerial or backpack spray applications or for delivery using caulk gun-type or grease pump-type devices. Other formulation embodiments can be provided as solid blocks, granules or powders.

Abstract: The present invention relates to a method for the control and the treatment of post-harvest diseases in fruits and vegetables by means of simultaneous and combined application of (i) a first formulation, which is aqueous or in the form of an emulsifiable concentrate, which comprises a plant extract and is applied in the form of an aqueous solution and (ii) a second formulation, in the form of an emulsifiable concentrate, soluble liquid or concentrated suspension, which is applied as an aqueous solution, selected from amongst: a plant-strengthening formulation that contains at least one phosphite salt; a fungicidal formulation that contains at least one synthetic fungicide of the phosphonate family, preferably ethyl phosphonic acid salts; or a combination thereof. Each formulation may be a different composition or form part of a single composition.

Abstract: An embodiment in accordance with the present invention provides an apparatus and method for inserting a lens into pocket in the cornea. The apparatus includes a handle, a plunger extending movably through the lumen of the handle, and a first and a second actuators. In particular the plunger includes a distal segment which extends beyond the distal end of the handle and the first and second actuators are coupled to the plunger configured in such a way to provide different ranges of motion and synchronized movement of a bottom, middle, and top tines of the plunger for improved and safer lens insertion into the corneal pocket.

Abstract: The present invention consists of a computer security method that enables all users of a computer application to enjoy superior security levels when sensitive information is being exchanged with transaction applications. The method of the present invention consists of developing a virtual desktop or isolated execution environment that restricts the user to working in a specific zone. Said virtual desktop or isolated environment is programmed in such a way that message listening techniques such as hooking or quartz techniques are implanted for intercepting messages between the transaction application, such as the electronic bank, and the user's Operating System (OS). The method that is used in the present invention also blocks special key combinations in order to prevent malicious code execution in OS support devices, like Apple® IOS and Google™ Android, where special key combinations are not evident, but combinations such as “*#06#? exist.

Abstract: An insect control formulation including methyl eugenol, cue lure and a biodegradable wax carrier is a surprisingly effective attractant for Oriental fruit flies (Bactrocera dorsalis) and Melon flies (Bactrocera cucurbitae). Formulation embodiments that include at least one insect toxicant are surprisingly effective for use in fruit fly MAT attract and kill systems, and are suitable for on-crop or off-crop uses. Formulation embodiments can be provided as aqueous emulsions having viscosities appropriate for use in aerial or backpack spray applications or for delivery using caulk gun-type or grease pump-type devices. Other formulation embodiments can be provided as solid blocks, granules or powders.