Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.

Abstract: The invention relates to compounds of structural formula I wherein A, D, and E are independently N or C—R3, G, H, and J are independently N or C, K is N or C—H, L is N, N—R3 or C—R3, and A, D, E, G, H, J, K, and L together cannot have more than 4 N, R1 is selected from (C6 to C10) aryl, (C2 to C9) heteroaryl, and 5-indolyl, wherein each of the said (C6 to C10) aryl and (C2 to C9) heteroaryl is substituted with at least one R4a group, and wherein said (C2 to C9) heteroaryl is C-attached, and R2 is selected from the group consisting of

Abstract: Access assemblies include an instrument valve housing and a valve assembly disposed within a cavity of the instrument valve housing. The valve assembly includes a guard assembly, and a seal assembly disposed adjacent to the guard assembly. The seal assembly includes first, second, third, and fourth seal sections. The first seal section is nested within the second seal section, the first and second seal sections are nested within the third seal section, and the first, second, and third seal sections are nested within the fourth seal section.

Abstract: Surgical access assemblies include an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a centering mechanism for maintaining the seal assembly and guard assembly centered within a cavity of the instrument valve. The seal assembly includes a multi-petal seal member and upper and lower support members. The upper and lower support members sandwich the multi-petal seal member therebetween to reduce and/or eliminate leaks through the multi-petal seal member.

Abstract: An access assembly includes an instrument valve housing and a valve assembly disposed within the instrument valve housing. The instrument valve housing includes upper and lower housing sections. The valve assembly includes a centering mechanism, a seal assembly, and a guard assembly. The centering mechanism is configured to bias the valve assembly towards a generally centered position within the instrument valve housing. The centering mechanism includes a base seal member having an annular base and a flange portion. The flange portion includes an arcuate portion configured to adjustably engage first and second surfaces of the instrument valve housing in a sealing relation. The seal assembly is attachable to the centering mechanism. The seal assembly is configured to engage a surgical instrument inserted into the access assembly in a sealing relation. The guard assembly is attachable to the centering mechanism.

Abstract: Access assemblies includes an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, and a seal assembly disposed distal of the guard assembly. In embodiments, the seal assembly includes a plurality of seal segments in an overlapping configuration. Each seal segment of the plurality of seal segments includes a seal portion having a smooth surface and a ribbed surface. The ribbed surfaces include a central spline extending in a radial direction and plurality of concentric ribs extending outwardly from the central spline.

Abstract: Provided herein are methods and compositions useful for inhibiting microbe growth. The methods can comprise contacting the microbe with an antimicrobial agent and bicarbonate. In some embodiments, provided herein are methods for treating or preventing a microbial infection, comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent.

Abstract: A ligation clip includes a first jaw, a second jaw, and a hinge. The first jaw has a body having an inner surface defining a first clamping surface and an outer surface. The second jaw has a body having an inner surface defining a second clamping surface and an outer surface. The hinge is integrally formed with the first and second jaws and includes an inner hinge portion and an outer hinge portion. The inner hinge portion has an inner surface that is contiguous with the first and second clamping surfaces of the first and second jaws, and an outer surface. The inner surface of the inner hinge portion is defined by a plurality of curved sections. The hinge is configured to facilitate pivotal movement of the first jaw in relation to the second jaw between an open position and a clamped position.

Abstract: Compounds as exemplified by compound A are useful in the treatment of arenavirus infections and viral infections mediated by arenavirus glycoproteins.

Abstract: A surgical access assembly includes a cannula, a valve housing attached to the cannula, and a valve assembly positioned in the valve housing. The valve assembly includes a centering mechanism with a hoop and fingers, a ring with a flange at one end of the ring, a retainer having first and second discs, a guard having a frame and flaps attached to the frame, and a seal with petals attached to a support. The guard is at least partially disposed in the first disc and the seal is at least partially disposed in the second disc.

Abstract: The invention relates to compounds of structural formula I wherein A, D, and E are independently N or C—R3, G, H, and J are independently N or C, K is N or C—H, L is N, N—R3 or C—R3, and A, D, E, G, H, J, K, and L together cannot have more than 4 N, R1 is selected from (C6 to C10) aryl, (C2 to C9) heteroaryl, and 5-indolyl, wherein each of the said (C6 to C10) aryl and (C2 to C9) heteroaryl is substituted with at least one R4a group, and wherein said (C2 to C9) heteroaryl is C-attached, and R2 is selected from the group consisting of

Abstract: A computer-implemented method for dynamic, data-driven consolidation of user interface interactions requesting roadside assistance. The method includes identifying a data objective requiring user data, accessing user data, and determining whether the user data satisfies a confidence threshold. Based at least in part on the confidence threshold determination, one of a first data objective representation and a second data objective representation is displayed. A request for roadside assistance—following satisfaction of the confidence threshold—is also issued.

Abstract: A ligation clip includes a first jaw, a second jaw, and a hinge. The first jaw has a body having an inner surface defining a first clamping surface and an outer surface. The second jaw has a body having an inner surface defining a second clamping surface and an outer surface. The hinge is integrally formed with the first and second jaws and includes an inner hinge portion and an outer hinge portion. The inner hinge portion has an inner surface that is contiguous with the first and second clamping surfaces of the first and second jaws, and an outer surface. The inner surface of the inner hinge portion is defined by a plurality of curved sections. The hinge is configured to facilitate pivotal movement of the first jaw in relation to the second jaw between an open position and a clamped position.

Abstract: A ligation clip removal device includes an elongate body, a tool assembly, and a drive member. The tool assembly is supported on a distal portion of the elongate body and includes a first jaw and a second jaw pivotably supported in relation to the first jaw between an open position and a clamped position. Each of the first and second jaws includes a clip engagement surface that defines a recess having a longitudinal portion and a first transverse portion that intersects the longitudinal portion. The longitudinal portions of the recesses are configured to receive a leg of a ligation clip and the first transverse portion of the recess is configured to receive a portion of a boss of the ligation clip. The drive member is engaged with and movable in relation to the tool assembly to move the first and second jaws between the open and clamped positions.

Abstract: A clip applier includes an outer tube, an actuation member, and an end effector. The actuation member has a distal portion including a cam member. The end effector includes a first jaw and a second jaw. Each of the first and second jaws includes a proximal portion that defines a cam slot. The cam member of the actuation member is operatively engaged with the cam slots of the first and second jaws such that movement of the actuation member from the first position to the second position causes movement of the end effector from an intermediate position to the open position and subsequently to the clamped position.

Abstract: A dynamic touch user interface system includes a touch-input interface, one or more visual indicators, and a plurality of sensors. The touch-input interface has a reference surface that covers one or more touch elements. The touch elements define an active area that allows user communication with a computer through touch. The active area is relocatable along the reference surface in response to detected circumstances. The visual indicators visually identify a location of the active area. The sensors detect the circumstances affecting a relocation of the active area.

Abstract: Access assemblies includes an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, and a seal assembly disposed distal of the guard assembly. In embodiments, the seal assembly includes a plurality of seal segments in an overlapping configuration. Each seal segment of the plurality of seal segments includes a seal portion having a smooth surface and a ribbed surface. The ribbed surfaces include a plurality of ribs extending in a radial direction.

Abstract: Access assemblies include an instrument valve housing and a valve assembly. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a gimbal mount assembly supporting the guard assembly and the seal assembly. The gimbal mount assembly is configured to permit angulation of the valve assembly relative to the instrument valve housing.

Abstract: Access assemblies include an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a centering mechanism for maintaining the seal assembly and guard assembly centered within a cavity of the instrument valve. The guard assembly includes a support ring and a plurality of guard sections disposed distally of the support ring.

Abstract: Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium or treating or preventing a bacterial infection.