Abstract: A multi-part ligation clip assembly includes a first beam, a second beam, and a spine that is positioned about the first and second beams to reinforce the clip assembly when the clip assembly is in a clamped position.

Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.

Abstract: An access assembly includes an instrument valve housing and a valve assembly disposed within the instrument valve housing. The instrument valve housing includes upper and lower housing sections. The valve assembly includes a centering mechanism, a seal assembly, and a guard assembly. The centering mechanism is configured to bias the valve assembly towards a generally centered position within the instrument valve housing. The centering mechanism includes a base seal member having an annular base and a flange portion. The flange portion includes an arcuate portion configured to adjustably engage first and second surfaces of the instrument valve housing in a sealing relation. The seal assembly is attachable to the centering mechanism. The seal assembly is configured to engage a surgical instrument inserted into the access assembly in a sealing relation. The guard assembly is attachable to the centering mechanism.

Abstract: A velocity indication system of a vehicle includes one or more velocity sensors configured to sense a vehicle velocity and to generate velocity data therefrom. The system also includes a control unit configured to receive the velocity data and to generate a control signal based on the velocity data. The system also includes a tactile velocity indicator. The tactile velocity indicator includes a frame that defines an opening therein. The tactile velocity indicator also includes a haptic element, at least partially protruding from the opening so as to be touchable by a passenger of the vehicle via the opening. The tactile velocity indicator also includes an electric motor configured to drive the haptic element in response to the control signal to move relative to the frame according to a haptic element velocity that corresponds to the sensed vehicle velocity.

Abstract: A dynamic touch user interface system includes a touch-input interface, one or more visual indicators, and a plurality of sensors. The touch-input interface has a reference surface that covers one or more touch elements. The touch elements define an active area that allows user communication with a computer through touch. The active area is relocatable along the reference surface in response to detected circumstances. The visual indicators visually identify a location of the active area. The sensors detect the circumstances affecting a relocation of the active area.

Abstract: A system for holding a personal object for a motor vehicle is described. The system includes a segmented surface having a plurality of adjacent surface elements. The system also includes a plurality of actuators, each actuator associated with a surface element and configured to extend and/or retract the associated surface element. The system also includes a sensor system configured to detect circumstances affecting the holding of the personal object by the segmented surface. The system also includes a controller operably coupled to the actuators and the sensor system, the controller configured to selectively control the actuators to extend and/or retract associated surface elements based on the detected circumstances so as to form a holding area appropriate for holding the personal object.

Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.

Abstract: A surgical ligation clip includes a first jaw, a second jaw, and a hinge portion that pivotably couples the first jaw to the second jaw. The first and second jaws define respective clamping surfaces and include locking elements. The clamping surfaces support retention structure that minimizes movement of the clamp about tissue when the ligation clip is in the clamped position. The locking elements are supported on the first and second jaws and are movable into engagement with each other to retain the ligation clip in the clamped position.

Abstract: A surgical ligation clip includes a first jaw, a second jaw, and a hinge portion that pivotably couples the first jaw to the second jaw. The first and second jaws define respective clamping surfaces and include spaced bosses. Each of the spaced bosses include a transverse portion and a head portion that is oversized and has a diameter that is larger than the diameter of the transverse portions. The oversized head portions allow for the ligation clips to be securely supported on a clip applicator.

Abstract: A dynamic ergonomic surface system for use in a motor vehicle includes an ergonomic surface that is inlayed in a surrounding surface and transitions between states, including: a neutral state in which the ergonomic surface is consistent with the surrounding surface, and at least one ergonomic support state in which the ergonomic surface provides ergonomic support for a user operating an input device. The dynamic ergonomic surface system also includes a sensor system that detects events triggering the transition between states, and a controller that controls the ergonomic surface to transition between the states in response to the detected events.

Abstract: A temperature control system for a motor vehicle includes a thermotactile user interface having a plurality of adjacent thermoelectric units arranged in an array, each thermoelectric unit having a thermoelectric surface whose temperature varies with an amount of current supplied to the thermoelectric unit. A controller controls the amount of current supplied to each thermoelectric unit such that the temperature of each thermoelectric surface in the array progressively increases or decreases along the array. The system also includes a sensor system that detects a user selection of one of the thermoelectric surfaces as corresponding to a desired temperature. In response to the detected user selection, the controller controls a temperature of a temperature controlled medium of the motor vehicle, e.g., controls the vehicle's cabin climate, to match the temperature of the selected thermoelectric surface.

Abstract: A velocity indication system of a vehicle includes one or more velocity sensors configured to sense a vehicle velocity and to generate velocity data therefrom. The system also includes a control unit configured to receive the velocity data and to generate a control signal based on the velocity data. The system also includes a tactile velocity indicator. The tactile velocity indicator includes a frame that defines an opening therein. The tactile velocity indicator also includes a haptic element, at least partially protruding from the opening so as to be touchable by a passenger of the vehicle via the opening. The tactile velocity indicator also includes an electric motor configured to drive the haptic element in response to the control signal to move relative to the frame according to a haptic element velocity that corresponds to the sensed vehicle velocity.

Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.

Abstract: A polymeric ligation clip includes first and second jaws that support a latch mechanism. The latch mechanism includes a latch member that is supported on one end of the first jaw and a latch member receiver that is supported on one end of the second jaw. The latch member and the latch member receiver are movable into engagement with each other when the ligation clip is moved to a clamped position to secure the ligation clip in the clamped position. The latch mechanism is configured to facilitate closure of the ligation clip with less force than required for closure of existing polymeric ligation clips. In addition, the latch mechanism is configured to provide more secure closure of the ligation clip to minimize a likelihood of inadvertent opening of the ligation clip during use.

Abstract: Access assemblies includes an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, and a seal assembly disposed distal of the guard assembly. In embodiments, the seal assembly includes a plurality of seal segments in an overlapping configuration. Each seal segment of the plurality of seal segments includes a seal portion having a smooth surface and a ribbed surface. The ribbed surfaces include a central spline extending in a radial direction and plurality of concentric ribs extending outwardly from the central spline.

Abstract: Polymeric ligation clips and a clip applier for applying a polymeric ligation clip to tissue are disclosed herein. More particularly, the polymeric ligation clips include separate first and second beams that can be coupled to each other and are movable from a reduced diameter open position in which minimal strain is placed on the ligation clip to a clamped position and to a clip applier for delivering such a ligation clip to a surgical site.

Abstract: Access assemblies includes an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a centering mechanism for maintaining the seal assembly and guard assembly centered within a cavity of the instrument valve. In embodiments, the seal assembly includes a plurality of seal sections that are movable from an unfolded configuration to folded configuration in which the seal assembly forms a hexagonal member defining an opening to facilitate sealed passage of a surgical instrument. The seal sections may include a tapered inner edge for engaging a surgical instrument inserted through the instrument valve housing.

Abstract: Surgical access assemblies include an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a centering mechanism for maintaining the seal assembly and guard assembly centered within a cavity of the instrument valve. The seal assembly includes a multi-petal seal member and upper and lower support members. The upper and lower support members sandwich the multi-petal seal member therebetween to reduce and/or eliminate leaks through the multi-petal seal member.