Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

Abstract: Using an action registry to edit data across users and devices is described. In one or more implementations, a user editing data in an application requests to share the data with another user or another device for further editing. Responsive simply to the request or based on an exchange of content transfer information, the data is communicated to the selected user or device. Using information maintained by an action registry, a list of applications capable of editing the data is presented to the selected user or via the selected device. Upon selection of an application from the list, the selected application is launched. Once changes are made to the data by the selected user or device, those changes can be saved and the changed data automatically returned to the original user and/or device. The changed data can then be automatically presented to the original user or on the original device.

Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are novel dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.

Abstract: A cooling system, an apparatus for producing hyperpolarized samples, where the apparatus includes the cooling system, and a method for assembling and using the cooling system are disclosed. The cooling system includes a cryogenic chamber, a cooling plate, a sample sleeve, a thermal switch, and an interposer. Also, the cryogenic chamber includes a cryogenic fluid and the cooling plate is disposed in the cryogenic chamber, in contact with the cryogenic fluid. Further, the sample sleeve is configured to receive a sample. The sample sleeve is at least partially inserted in the cryogenic chamber. The thermal switch is disposed between the cooling plate and the sample sleeve. Moreover, the interposer is disposed between at least one of (i) the thermal switch and the cooling plate and (ii) the thermal switch and the sample sleeve. The interposer includes a gallium indium tin alloy.

Abstract: Methods and systems for delivering a package to a customer employ an on-demand locker assembly having a plurality of lockers. A computer-implemented method of staging delivery of a package to a customer includes displaying a network link that is selectable by the customer on an electronic client device. In response to selection of the network link, the package is transferred to one of the lockers. An access code for the locker is sent to the electronic client device. Upon entry of the access code, the locker is opened to provide the customer with access to the package to retrieve the package from the locker.

Abstract: The present invention relates to a catalytic process for preparing pyrazoles of formula V comprising the step of cyclizing hydrazone substituted ?,?-unsaturated carbonyl compounds by reacting them with hydrogen in a reaction mixture comprising as components (a) a hydrogenation catalyst, (b) an acid selected from Brønsted acids, ammonium salts of Brønsted acids, and Lewis acids, (c) a protic solvent, and optionally (d) an aprotic solvent.

Abstract: The present invention relates to a process for the purification of pyrazolpyridazines of formula I wherein the variables are as defined in the specification, by adding HCl to a solution of the pyrazolpyridazine in an inert solvent under non-aqueous conditions, effecting crystallization of the HCl-salt, isolating the resulting precipitate.

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.

Abstract: A magnetic resonance imaging (MRI) coil system is provided that includes a gradient coil and a flow inlet. The gradient coil includes a flow channel passing therethrough. The gradient coil defines an eye and an end. The eye is disposed proximate the center of the gradient coil. The flow inlet is disposed along the gradient coil between the eye and the end. Cooling fluid is provided to the gradient coil via the flow inlet, and removed from the gradient coil via the eye and the end.

Abstract: A method of manufacturing includes producing a gradient coil assembly having one or more cooling channels for a magnetic resonance imaging system by a process that includes printing a cooling channel template having a first end, a second end, and a hollow passage extending between the first end and the second end, disposing a dielectric material over at least a portion of the cooling channel template to generate a dielectric layer having the cooling channel template, and removing the cooling channel template from the dielectric layer to thereby produce the one or more cooling channels within the dielectric layer such that the one or more cooling channels have a pattern corresponding to a geometry of the cooling channel template.

Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are novel dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

Abstract: A magnetic resonance imaging (MRI) coil system is provided that includes a gradient coil and a flow inlet. The gradient coil includes a flow channel passing therethrough. The gradient coil defines an eye and an end. The eye is disposed proximate the center of the gradient coil. The flow inlet is disposed along the gradient coil between the eye and the end. Cooling fluid is provided to the gradient coil via the flow inlet, and removed from the gradient coil via the eye and the end.

Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are novel dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims or the description.

Abstract: Methods and systems for delivering a package to a customer employ an on-demand locker assembly having a plurality of lockers into which a package is placed for retrieval by the customer. A computer-implemented method for delivering a package to a customer includes receiving the package into a facility. The customer is notified that the package has arrived at the facility. In response to receiving a check-in notification from the customer, the package is placed into a locker having a closed configuration that blocks access to the package by the customer. The customer is sent an access code for use by the customer in retrieving the package from the locker. Entry of the access code by the customer is received. In response to receipt of the entry of the access code, the locker is reconfigured so that the customer can retrieve the package from the locker.

Abstract: The present invention relates to a process for the purification of pyrazolpyridazines of formula I wherein the variables are as defined in the specification, by adding HCl to a solution of the pyrazolpyridazine in an inert solvent under non-aqueous conditions, effecting crystallization of the HCl-salt, isolating the resulting precipitate.

Abstract: A cooling system, an apparatus for producing hyperpolarized samples, where the apparatus includes the cooling system, and a method for assembling and using the cooling system are disclosed. The cooling system includes a cryogenic chamber, a cooling plate, a sample sleeve, a thermal switch, and an interposer. Also, the cryogenic chamber includes a cryogenic fluid and the cooling plate is disposed in the cryogenic chamber, in contact with the cryogenic fluid. Further, the sample sleeve is configured to receive a sample. The sample sleeve is at least partially inserted in the cryogenic chamber. The thermal switch is disposed between the cooling plate and the sample sleeve. Moreover, the interposer is disposed between at least one of (i) the thermal switch and the cooling plate and (ii) the thermal switch and the sample sleeve. The interposer includes a gallium indium tin alloy.

Abstract: Using an action registry to edit data across users and devices is described. In one or more implementations, a user editing data in an application requests to share the data with another user or another device for further editing. Responsive simply to the request or based on an exchange of content transfer information, the data is communicated to the selected user or device. Using information maintained by an action registry, a list of applications capable of editing the data is presented to the selected user or via the selected device. Upon selection of an application from the list, the selected application is launched. Once changes are made to the data by the selected user or device, those changes can be saved and the changed data automatically returned to the original user and/or device. The changed data can then be automatically presented to the original user or on the original device.