Abstract: The device (1) comprises an inlet element (28) comprising an interface (40) for connecting to an artificial vagina and delimiting an inlet opening (14), a filter associated with the inlet element (28) and delimiting therewith an inlet chamber (41) on the side of a first face of the filter turned towards the opening (14) and a collection bag (4) extending between a closed end (8) and an end (7) having an opening (6) in which said inlet element is engaged; said bag and said filter delimiting a collection chamber (42) on the side of the second face (18) of the filter turned towards the end (8); by means of which semen entering through the opening (14) passes through the filter and is collected in the collection chamber (42); characterized in that the filter is formed by a perforated wall (30) in one piece with the inlet element.

Abstract: The invention relates to a straw comprising a tube (11) and a gas-permeable and liquid-tight stopper (12), said stopper (12) being arranged in the tube (11), close to an end (16). The invention is characterised in that the stopper (12) comprises an indicator component (20) having a first pre-determined colour in the absence of previous contact with said substance (21) and a second pre-determined colour, of a different shade from that of the first colour, once it has been in contact with said substance (21). The assembly comprises the straw (10) and a device (26) for controlling the filling of the straw.

Abstract: The container straw comprises a tube (11) and a stopper (12) that is permeable to gasses and impermeable to liquids, which stopper (12) is arranged in the tube (11) near one end (16), characterized in that it comprises an indicator component (20) configured to emit, at least when the container straw (10) is full, light the spectrum of which contains at least one spike having a peak of predetermined wavelength. The assembly comprises the container straw (10) and a container straw recognition device (26).

Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: The straw (11) filling device comprises a casing body having a cavity (43) in which the needle (9) of a nozzle (7) is placed. The needle is inserted into the straw tube (12) received in the cavity. The casing body is attached to a carriage separately from the needle. The cavity comprises a distal opening located on the distal end side of the needle, a proximal opening located on the proximal end side of the needle, and a longitudinal opening extending from the distal opening to the proximal opening, thus enabling placement and removal of the needle in and out of the cavity in a direction transverse to the direction of the needle and preventing an adult finger accessing the distal end of the needle. The machine comprises a device of this type and a conveyor (2) designed to keep the straw tube in a filling position during each cycle.

Abstract: The present disclosure relates to a curable two-component polyurethane adhesive composition comprising: a) a first component C1 comprising at least one polyol; b) a second component C2 comprising at least one isocyanate; c) a polyurethane catalytic system comprising a first bicyclic amine and a second bicyclic amine; and d) optionally, a particulate filler material. The present disclosure also relates to a sandwich panel comprising at least a core layer, at least a first structural panel and at least a second structural panel and to a method of manufacturing and using thereof.

Abstract: The invention relates to a straw comprising a tube (11) extending between a first end (13) and a second end (14) and comprising a stopper (12) placed in the tube near the first end thereof and extending between a first end (17) facing the first end of the tube, and a second end (20) facing the second end of the tube, said stopper and said tube being configured such that, after a liquid substance (22) has come in contact with the stopper via the second end thereof, the stopper blocks the passage of the liquid substance therethrough and is, by pushing on the first end thereof, slidable into the tube toward the second end thereof. Moreover, the stopper comprises, on the side of the second end of the tube, a barrier pad (16) consisting of hydrophobic threads over the entire cross-section of the tube.

Abstract: The invention relates to a La-1-like peptide agent that increases sperm motility. It is non-toxic and it may be used to treat male infertility in humans, and also to increase fertility in animals. It may be used in artificial reproductive techniques such as in vitro fertilisation (IVF), including intra-cytoplasmic sperm injection (ICSI). The La-1 like peptide agent may also be used in artificial insemination techniques such as intra-cytoplasmic uterine injection (IUI).

Abstract: The system comprises a straw and a liquid dilution medium. The straw comprises a tube (11) extending between a first end and a second end and comprises a gas-permeable, liquid-tight plug, said plug being arranged in the tube (11) in the vicinity of the first end of same and extending between a first end turned towards the first end of the tube (11) and a second end turned towards the second end of the tube (11). Said plug comprises an element (14) impregnated with a reagent (22) at least in the vicinity of a first end turned towards the second end of the tube (11). The liquid medium is provided to produce, by mixing, in predefined conditions, the liquid substance (21). The reagent (22) and the medium(27) are configured such that, when the substance (21) comes into contact with the first end of the impregnated element (14), it forms a hydrogel.

Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Abstract: The straw comprises a tube (11) and a gas-permeable liquid-tight stopper (12), which stopper is disposed in the tube in the neighborhood of one end (16), which tube and which stopper are configured for the stopper to be able to slide in the tube towards the other end (17), said tube being transparent or translucent, said stopper comprising an identifier component (13) configured to emit, when it is illuminated with ultraviolet light, light of which the spectrum comprises at least one peak having a crest of predetermined wavelength in visible light, whereas when it is illuminated by visible light said identifier component does not emit said light of which the spectrum comprises said peak.

Abstract: The invention concerns a system for collecting animal semen, comprising a container (3) configured to be mounted on an end (9) of an artificial vagina (2), having an internal space (15) configured to receive said semen and configured to comprise a first dilution extender (5) before receiving said semen, and said system (1) comprises a collecting device (4) configured to be at least partially inserted into said container and to be fastened to said vagina, and being interposed between said vagina and said container, said collecting device comprising a flow channel (23) for said semen extending within said internal space of said container and a discharge aperture (26) for said semen open to said internal space; and said system is configured to prevent, at least for the most part, said first dilution extender from passing in said flow channel of said collecting device.

Abstract: The invention relates to a storage receptacle (1) with a longitudinal opening (5) through which straws (2) for packing liquid-based substance are passed in a predetermined orientation of the straws, a housing (3) provided for the straws and configured to be inserted slidably in a cover (4) of the receptacle, the latter having an open configuration, in which the housing is partially inserted in the cover and the opening is free for the passage of the straws, and a closure configuration, in which the housing is inserted in the cover and the opening is closed by the cover in order to prohibit the passage of the straws. The housing has a parallelepipedal shape, a first front wall in which the opening is formed, a first bottom wall, two first longitudinal wails extending parallel to the opening, and two first side walls which each have two diagonals of a length less than or equal to the length of the straws.

Abstract: The bag comprises two flexible sheets (11) attached to each other by a weld area delimiting a pouch having a predefined volume when said bag is filled, said pouch being designed to contain a dose (27) of said diluted animal semen having said predefined volume. The surface (30) of each of said flexible sheets (11) faces said pouch (14) which is part of a layer (35) of weldable thermoplastic material. For one or preferably for each of said sheets (11), said layer of weldable thermoplastic material (35) comprises triclosan; and the ratio between said predefined volume of said pouch and the sum of the areas of the surfaces (30) of said sheets (11) facing said pouch is between 0.3 ml/cm2 and 0.5 ml/cm2. The system comprises such bags and an antibiotic-free dilution medium.

Abstract: The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection.

Abstract: An assembly and method of forming a press cutting die assembly that is configured to perforate a tissue graft blank during cutting of the blank from a bulk graft material. The press cutting die assembly includes a frame, a perimeter blade, and a plurality of fenestration blades that extend between respective portions of the perimeter blade. In a preferred embodiment, the plurality of fenestration blades are provided in at least two groups to form a repeating pattern of preferably uniformly spaced perforations within the perimeter of the blank. Such a press cutting die assembly is particularly applicable for cutting biologically compatible materials having a desired shape and uniform fenestration pattern from a bulk source of the biologically compatible material.

Abstract: An assembly and method of forming a press cutting die assembly that is configured to perforate a tissue graft blank during cutting of the blank from a bulk graft material. The press cutting die assembly includes a frame, a perimeter blade, and a plurality of fenestration blades that extend between respective portions of the perimeter blade. In a preferred embodiment, the plurality of fenestration blades are provided in at least two groups to form a repeating pattern of preferably uniformly spaced perforations within the perimeter of the blank. Such a press cutting die assembly is particularly applicable for cutting biologically compatible materials having a desired shape and uniform fenestration pattern from a bulk source of the biologically compatible material.

Abstract: The installation (1) comprises a treatment machine (12) and a supply and positioning device (16) configured to receive the straws (2) and dispose them one by one in a predetermined orientation for their treatment by said machine. The device (16) comprises a curved ramp (52) having a reception portion (64) for the straws (2) and an ejection portion (65) for the straws, the ramp being configured to convey, to the ejection portion (65), a straw (2) received on the reception portion (64) and sliding on the ramp (52), the ramp having a concave profile such that said profile has an orientation closer to the vertical in the reception portion (64) than in the ejection portion (65), such that a straw received on the reception portion (64) is accelerated to the ejection portion (65) at which the straw is guided and ejected with a predetermined orientation.

Abstract: The sheath (30) comprises a tube (31) and an end piece (32) that comprises a foot (33) introduced into an end portion of the tube (31), and a head (34) arranged in the extension of the tube (31). The foot (33) comprises, on the outer surface (40) thereof, a plurality of annular ribs (41-44) facing the inner surface (45) of the tube (31). The head (34) comprises a shoulder (38) facing the section (39) of the tube (31), projecting over the root of the foot (33). The end piece (32) and the tube (31) are attached to the periphery of at least one of said annular ribs exclusively by intrinsic welding. The method comprises the step of carrying out a peripheral tightening of the outer surface (37) of the tube on a level with the ribs (41-44), and the step of applying a sonotrode to the outer surface (35-36) of the head (34).

Abstract: The present invention relates to a composition for use in low dose artificial insemination and to a process for artificial insemination of a female mammal using a dose of sperm originating from a male mammal of the same species that is significantly lower than necessary in the absence of the composition. The preferred female mammal is a sow (sus scrofa), and preferably the composition is for use in artificial uterine insemination, and the process for artificial insemination preferably is uterine insemination.