Abstract: A clip applier includes an outer tube, an actuation member, and an end effector. The actuation member has a distal portion including a cam member. The end effector includes a first jaw and a second jaw. Each of the first and second jaws includes a proximal portion that defines a cam slot. The cam member of the actuation member is operatively engaged with the cam slots of the first and second jaws such that movement of the actuation member from the first position to the second position causes movement of the end effector from an intermediate position to the open position and subsequently to the clamped position.

Abstract: A ligation clip includes a first jaw, a second jaw, and a hinge. The first jaw has a body having an inner surface defining a first clamping surface and an outer surface. The second jaw has a body having an inner surface defining a second clamping surface and an outer surface. The hinge is integrally formed with the first and second jaws and includes an inner hinge portion and an outer hinge portion. The inner hinge portion has an inner surface that is contiguous with the first and second clamping surfaces of the first and second jaws, and an outer surface. The inner surface of the inner hinge portion is defined by a plurality of curved sections. The hinge is configured to facilitate pivotal movement of the first jaw in relation to the second jaw between an open position and a clamped position.

Abstract: A specimen retrieval device includes a tubular body, an inner shaft slidably positioned within a longitudinal bore of the tubular body, and a specimen bag supported on the distal portion of the inner shaft. In embodiments, the tubular body tubular body is formed of a lubricious material. The specimen bag is formed from a pattern and welded by a radiofrequency welder. The specimen bag includes a tail section through which the inner shaft passes, and the tail section may be attached to a handle at a proximal portion of the inner shaft.

Abstract: Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.

Abstract: A ligation clip removal device includes an elongate body, a tool assembly, and a drive member. The tool assembly is supported on a distal portion of the elongate body and includes a first jaw and a second jaw pivotably supported in relation to the first jaw between an open position and a clamped position. Each of the first and second jaws includes a clip engagement surface that defines a recess having a longitudinal portion and a first transverse portion that intersects the longitudinal portion. The longitudinal portions of the recesses are configured to receive a leg of a ligation clip and the first transverse portion of the recess is configured to receive a portion of a boss of the ligation clip. The drive member is engaged with and movable in relation to the tool assembly to move the first and second jaws between the open and clamped positions.

Abstract: A surgical clip applier includes a handle and an elongated assembly having an outer shaft with a pair of flanges extending distally thereof in spaced-relation to define tissue stops. The elongated assembly further includes an end effector disposed partially within and extending distally from the outer shaft. A jaws component of the end effector includes first and second spaced-apart arms extending distally from a proximal portion between the opposed flanges of the outer shaft. The jaws component also includes first and second jaws disposed at free ends of the first and second spaced-apart arms, respectively. An inner drive sleeve disposed about the end effector within the outer shaft is movable from a proximal to a distal position to cam the first and second arms towards one another, thereby moving the first and second jaws from a spaced-apart to an approximated position to apply a surgical clip about tissue.

Abstract: A surgical ligation clip includes a first jaw and a second jaw pivotably coupled to the first jaw. The first and second jaws define first and second clamping surfaces, respectively, and have longitudinal ribs and transverse ribs that define first and second recesses on the first and second clamping surfaces. The second jaw is pivotable in relation to the first jaw from an open position to a clamped position to clamp tissue between the first and second clamping surfaces. In the clamped position, each of the longitudinal ribs on the first jaw is axially aligned with one of the longitudinal ribs on the second jaw and each of the transverse ribs on the first jaw is axially offset from each of the transverse ribs on the second jaw.

Abstract: A suture passer includes a handle assembly, a shaft extending distally from the handle assembly, an end effector assembly coupled to a distal end portion of the shaft, and an overstroke assembly. The overstroke assembly effects an opening and a closing of the end effector assembly while also preventing an overstroke of the handle assembly from damaging components of the suture passer.

Abstract: A surgical ligation clip includes a first jaw, a second jaw, and a hinge portion that pivotably couples the first jaw to the second jaw. The first and second jaws define respective clamping surfaces and include spaced bosses. Each of the spaced bosses include a transverse portion and a head portion that is oversized and has a diameter that is larger than the diameter of the transverse portions. The oversized head portions allow for the ligation clips to be securely supported on a clip applicator.

Abstract: A surgical ligation clip includes a first jaw, a second jaw, and a hinge portion that pivotably couples the first jaw to the second jaw. The first and second jaws define respective clamping surfaces and include locking elements. The clamping surfaces support retention structure that minimizes movement of the clamp about tissue when the ligation clip is in the clamped position. The locking elements are supported on the first and second jaws and are movable into engagement with each other to retain the ligation clip in the clamped position.

Abstract: The invention relates to compounds of structural formula I wherein A, D, and E are independently N or C—R3, G, H, and J are independently N or C, K is N or C—H, L is N, N—R3 or C—R3, and A, D, E, G, H, J, K, and L together cannot have more than 4 N, R1 is selected from (C6 to C10) aryl, (C2 to C9) heteroaryl, and 5-indolyl, wherein each of the said (C6 to C10) aryl and (C2 to C9) heteroaryl is substituted with at least one R4a group, and wherein said (C2 to C9) heteroaryl is C-attached, and R2 is selected from the group consisting of

Abstract: The present invention relates to multi-cell devices fabricated on a common substrate that are more desirable than single cell devices, particularly in photovoltaic applications. Multi-cell devices operate with lower currents, higher output voltages, and lower internal power losses. Prior art multi-cell devices use physical isolation to achieve electrical isolation between cells. In order to fabricate a multicell device on a common substrate, the individual cells must be electrically isolated from one another. In the prior art, isolation generally required creating a physical dielectric barrier between the cells, which adds complexity and cost to the fabrication process. The disclosed invention achieves electrical isolation without physical isolation by proper orientation of interdigitated junctions such that the diffusion fields present in the interdigitated region essentially prevent the formation of a significant parasitic current which would be in opposition to the output of the device.

Abstract: A ligation clip defines a longitudinal axis includes a first jaw, a second jaw, and a hinge portion that pivotably couples the first jaw to the second jaw. The first jaw has a first clamping surface that supports first ribs that defines an angle ? with the longitudinal axis. The second jaw has a second clamping surface in opposition to the first clamping surface and supports second ribs that define the angle ? with the longitudinal axis. Each of the first and second ribs includes a distal wall and a proximal wall and a wall in opposition to the opposing clamping surface. The distal wall of at least some of the first ribs is positioned in close proximity to the proximal wall of a respective one of the second ribs when the ligation clip is in the clamped position.

Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: A method for hosting a cloud-based broadband push-to-talk (PTT) configuration application includes detecting a user action taken at a remote client device providing an interface to the configuration application including an activation of an add group graphical object for adding a new group to an existing broadband PTT radio system, and further includes entrance of a unique identifier for the new group and entrance of whether the new group is a broadband-only group or a converged broadband and land-mobile-radio (LMR) group. A voice service stack associated with the broadband PTT radio system is updated to include the new group and existing other broadband mobile radios are updated via a voice service stack to reflect the added new group. Where the type of the new group is a converged broadband and LMR group, an LMR interface stack of the LMR radio system is updated to reflect the newly added group.

Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.

Abstract: Systems and methods for providing an electronic task assessment platform are disclosed. The system may include a first computing device, a second computing device and a server communicatively coupled by a network. A first computing device may include a web browser configured with an assessment builder that enables the creation of customizable assessments. A second computing device may include an assessment application for completion of the customized assessment related to task performance evaluations. The completed assessment may be provided to the server that performs objective evaluation of the completed assessment and generates a specialized report including statistical metrics relating to the task performance evaluations. The report is provided to the first computing device and/or the second computing device.

Abstract: A backpack with improved shoulder straps includes a set of fold-over panels formed respectively on the shoulder straps, wherein each of the fold-over panels extends from an inner side of the shoulder strap on which it is formed, folds over the shoulder strap, and attaches to an outer side of the shoulder strap on which it is formed. The improved shoulder straps mitigate chafing around the neck of a user.

Abstract: The invention provides rF1 antibody antibiotic conjugates and methods of using same.