Abstract: The invention relates to compounds of structural formula 1 wherein A is independently N or C—R3, R1 is selected from (C1 to C6) alkyl, (C2 to C6) alkenyl, (C2 to C6) alkynyl, (C3 to C10) cycloalkyl, (C5 to C10) cycloalkenyl, (C2 to C6) heterocycloalkyl, (C6 to C10) aryl, and (C2 to C9) heteroaryl, wherein each of the said (C1 to C6) alkyl, (C2 to C6) alkenyl, (C2 to C6) alkynyl, (C3 to C10) cycloalkyl, (C5 to C10) cycloalkenyl, (C2 to C9) heterocycloalkyl, (C6 to C10) aryl, and (C2 to C9) heteroaryl is optionally substituted with at least one R4 group, and wherein said (C2 to C9) heteroaryl is C-attached, and R2 is selected from the group consisting of

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: Access assemblies include an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a centering mechanism for maintaining the seal assembly and guard assembly centered within a cavity of the instrument valve. The guard assembly includes a support ring and a plurality of guard sections disposed distally of the support ring. The seal assembly includes a proximal seal member, an intermediate seal assembly, and a distal seal member, the intermediate seal assembly including a plurality of seal sections in a stacked configuration.

Abstract: Polymeric ligation clips and a clip applier for applying a polymeric ligation clip to tissue are disclosed herein. More particularly, the polymeric ligation clips include separate first and second beams that can be coupled to each other and are movable from a reduced diameter open position in which minimal strain is placed on the ligation clip to a clamped position and to a clip applier for delivering such a ligation clip to a surgical site.

Abstract: What is new within this engine in th field of the magnetic engine is that it uses the ball bearing gear piston as the catalyst to make the engine work, by this we mean that the ball bearing gear piston is the workhorse of the engine being that it moves to push down the piston to turn the crank.

Abstract: A rental self-service (“RSS”) computer system, including a processor and a memory, is provided. The processor is programmed to: (i) verify that a policyholder is eligible to receive a replacement rental; (ii) transmit a customized link to the eligible policyholder; (iii) receive an access request for access of a rental self-service portal, (iv) retrieve policyholder data using information extracted from the customized link; (v) pre-populate a portion of a searchable interface of the rental self-service portal using the retrieved policyholder data; (vi) cause rental vehicle data to be displayed to enable the policyholder to view available rental options and select a vehicle class; (vii) calculate a policyholder cost for renting a selected vehicle class; and (viii) cause to be displayed on the user device (a) the calculated policyholder cost and (b) an option to confirm the rental reservation.

Abstract: A cooling system and method of cooling electronic components comprising a tank (or other vessel) in which a dielectric liquid cools low power electronic components within the tank, while a conductive liquid cools high power electronic components in the tank. The conductive liquid is supplied via a plurality of cooling modules, each arranged on or in proximity to a high power component. A cooling module arranged within the tank may enclose one or more of the electronic components in the tank using a fluid-tight seal.

Abstract: A surgical access assembly includes a housing, a tubular member, and a valve assembly. The tubular member extends from the housing. The valve assembly is positioned in the housing and includes a centering mechanism, a guard assembly disposed on a first side of the centering mechanism, and an instrument seal disposed on a second side of the centering mechanism. The instrument seal including petals that are arrange in an overlapping arrangement.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: A system for instructing a user on repairing a vehicle configured to (i) receive, from the user, a request to repair a vehicle, including information about the vehicle; (ii) present, to the user via a user computer device, a user interface to allow the user to search for a repair facility to repair the vehicle; (iii) receive, from the user via the user interface, a selection of a repair facility; (iv) determine whether the selected repair facility is a select service location, where a select service location is a pre-authorized repair facility; and (v) if the selected repair facility is a select service location, transfer the information about the vehicle to a computer device associated with the selected repair facility.

Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.

Abstract: A monitoring system includes a mounting assembly for securing a recording device relative to a cannula assembly. The mounting assembly includes a cradle member configured to releasably retain the recording device and a support member including an elongate body. The elongate body has first and second ends. The first end includes a connecting portion for connecting the cradle member to the support member and the second end includes an engaging portion for securing the support member to the cannula assembly.

Abstract: A system for instructing a user on repairing a vehicle configured to (i) receive, from the user, a request to repair a vehicle, including information about the vehicle; (ii) present, to the user via a user computer device, a user interface to allow the user to search for a repair facility to repair the vehicle; (iii) receive, from the user via the user interface, a selection of a repair facility; (iv) determine whether the selected repair facility is a select service location, where a select service location is a pre-authorized repair facility; and (v) if the selected repair facility is a select service location, transfer the information about the vehicle to a computer device associated with the selected repair facility.

Abstract: Access assemblies includes an instrument valve housing and a valve assembly disposed within the cavity of the instrument valve housing. The valve assembly includes a guard assembly, a seal assembly disposed adjacent to the guard assembly, and a centering mechanism for maintaining the seal assembly and guard assembly centered within a cavity of the instrument valve. In embodiments, the seal assembly includes a plurality of seal sections that are movable from an unfolded configuration to folded configuration in which the seal assembly forms a hexagonal member defining an opening to facilitate sealed passage of a surgical instrument. The seal sections may include a tapered inner edge for engaging a surgical instrument inserted through the instrument valve housing.

Abstract: A fixation device for folding a seal member includes a frame having a horizontal portion and an upright portion, a press assembly secured to the upright portion of the frame, and a nest assembly secured to the horizontal portion of the frame. The press assembly includes a handle assembly and an anvil assembly operably connected to the handle assembly. The nest assembly includes a clamping assembly, a folding assembly supported on the clamping assembly, a support assembly supported on the folding assembly, and a nest member. The support assembly includes a support plate and a seal clamp for securing a seal member.

Abstract: The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections. X is selected from the group consisting of O and H; R1 is selected from (C6 to C10) aryl and (C2 to C9) heteroaryl, and R2 is selected from (C1 to C10) alkyl, (C1 to C10) alkenyl, (C1 to C10) alkynyl, (C3 to C10) cycloalkyl, and (C5 to C10) cycloalkenyl, and NR3aR3b is defined in the specification. These compounds are effective in treating filovirii infections including Ebolavirus and Marburg virus.

Abstract: A method of manufacturing a seal assembly for a surgical access assembly includes forming a seal assembly having a monolithic construction. The seal assembly includes a support member, seal sections connected to the support member, bridges disposed between adjacent seal sections and interconnecting the adjacent seal sections, and a plurality of standoffs extending from each seal section. The method also includes placing the seal assembly into a treatment bath, cutting the bridges, and folding the seal assembly.

Abstract: Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.

Abstract: A method for preparing for and providing dental treatment may include determining, by an action management system, that 3D scan data of a patient's dentition has been received by a treatment planning system. A treatment planning system may generate a treatment plan to move the patient's teeth from an initial position towards a final position, based on the 3D scan of the patient's dentition. The treatment plan may be provided to a dental professional system. The action management system my generate an object for display on the dental professional system indicating that the treatment plan has been provided. An indication that the treatment plan is approved for fabrication may be received, and instructions to fabricate a dental appliance based on the treatment plan may be sent.

Abstract: A dynamic ergonomic surface system for use in a motor vehicle includes an ergonomic surface that is inlayed in a surrounding surface and transitions between states, including: a neutral state in which the ergonomic surface is consistent with the surrounding surface, and at least one ergonomic support state in which the ergonomic surface provides ergonomic support for a user operating an input device. The dynamic ergonomic surface system also includes a sensor system that detects events triggering the transition between states, and a controller that controls the ergonomic surface to transition between the states in response to the detected events.