Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: The method and system for automatically controlling a path of travel of a vehicle include engaging an automatic control system when the security of the onboard controls is jeopardized. Engagement may be automatic or manual from inside the vehicle or remotely via a communication link. Any onboard capability to supersede the automatic control system may then be disabled by disconnecting the onboard controls and/or providing uninterruptible power to the automatic control system via a path that does not include the onboard accessible power control element(s). The operation of the vehicle is then controlled via the processing element of the automatic control system. The control commands may be received from a remote location and/or from predetermined control commands that are stored onboard the vehicle.

Abstract: The method and system for automatically controlling a path of travel of a vehicle include engaging an automatic control system when the security of the onboard controls is jeopardized. Engagement may be automatic or manual from inside the vehicle or remotely via a communication link. Any onboard capability to supersede the automatic control system may then be disabled by disconnecting the onboard controls and/or providing uninterruptible power to the automatic control system via a path that does not include the onboard accessible power control element(s). The operation of the vehicle is then controlled via the processing element of the automatic control system. The control commands may be received from a remote location and/or from predetermined control commands that are stored onboard the vehicle.

Abstract: A method of manufacturing a high pressure gas cylinder by deep drawing and ironing a blank of high strength steel, the periphery of the blank being ground prior to cupping.

Abstract: Phosphorus-containing catalysts that are suitable for polymerizing polyorganosiloxanes are prepared from tetraorgano phosphonium halides, a basic compound, such as sodium hydroxide, and an organosilicon compound. The catalyst must be prepared at a temperature of at least 30.degree. C. The catalysts are moisture sensitive but possess improved shelf-life stability. They are used to polymerize polyorganosiloxanes and can subsequently be inactivated by heating to a temperature above approximately 130.degree. C. for a suitable length of time.