Patents by Inventor Eric K. Lee
Eric K. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7353658Abstract: A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material therein for freezing, thawing, storing, and transporting, with the container also being receivable in the supporting structure. The temperature control unit has a cavity for receiving the supporting structure, when the supporting structure supports the container, and the transportation cart has a channel for receiving the supporting structure, when the supporting structure supports the container.Type: GrantFiled: August 9, 2006Date of Patent: April 8, 2008Assignee: Sartorius Stedim Freeze Thaw, Inc.Inventors: Nicolas Voute, Eric K. Lee, James Edward DeBeers, Brian J. Woodard, Ngee Jenn Lee
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Patent number: 7228688Abstract: A freezing and thawing unit for small amounts of biopharmaceuticals and biologics. The freezing and thawing unit is reduced in scale, as compared to a corresponding commercial or large-scale process. The freezing and thawing unit can be used for testing, preservation and/or processing of small quantities of biopharmaceuticals and biologics.Type: GrantFiled: December 12, 2003Date of Patent: June 12, 2007Assignee: Integrated Biosystems, Inc.Inventors: Nicolas Voute, Richard Wisniewski, Eric K. Lee, Jonathan N. Webb
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Patent number: 7137261Abstract: A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.Type: GrantFiled: March 21, 2005Date of Patent: November 21, 2006Assignee: Integrated Biosystems, Inc.Inventors: David C. Brown, Jonathan Cutting, Eric K. Lee, Nicolas Voute, Brian J. Woodard
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Patent number: 7104074Abstract: A system for freezing, thawing, transporting, and storing a biopharmaceutical material, which includes a container, a supporting structure, a temperature control unit, and a transportation cart. The container is adapted to receive the biopharmaceutical material therein for freezing, thawing, storing, and transporting, with the container also being receivable in the supporting structure. The temperature control unit has a cavity for receiving the supporting structure, when the supporting structure supports the container, and the transportation cart has a channel for receiving the supporting structure, when the supporting structure supports the container.Type: GrantFiled: June 4, 2003Date of Patent: September 12, 2006Assignee: Integrated Biosystems, Inc.Inventors: Nicolas Voute, Eric K. Lee, James Edward DeBeers, Brian J. Woodward, Ngee Jenn Lee
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Patent number: 6945056Abstract: A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.Type: GrantFiled: June 4, 2003Date of Patent: September 20, 2005Assignee: Integrated Biosystems, Inc.Inventors: David C. Brown, Jonathan Cutting, Eric K. Lee, Nicolas Voute, Brian J. Woodard
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Publication number: 20040139753Abstract: A freezing and thawing unit for small amounts of biopharmaceuticals and biologics. The freezing and thawing unit is reduced in scale, as compared to a corresponding commercial or large-scale process. The freezing and thawing unit can be used for testing, preservation and/or processing of small quantities of biopharmaceuticals and biologics.Type: ApplicationFiled: December 12, 2003Publication date: July 22, 2004Applicant: Integrated Biosystems, Inc.Inventors: Nicolas Voute, Richard Wisniewski, Eric K. Lee, Jonathan N. Webb
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Publication number: 20040006999Abstract: A system for controlled freezing, storing and thawing of a biopharmaceutical material includes a cavity for receiving a container for holding the biopharmaceutical material. Further included are at least a pair of opposed surfaces facing the biopharmaceutical material holding container. At least one of the opposed surfaces includes a moveable contacting surface configured to contact the container to inhibit a clearance between the container and the movable contacting surface. Also included is at least one heat transfer surface which is thermally coupled to the biopharmaceutical material holding container when the moveable contacting surface contacts the container. Also, the cavity may be configured to receive a frame for supporting the container holding the biopharmaceutical material. Further, the system may include a driver to move the frame holding the container inside the cavity.Type: ApplicationFiled: June 4, 2003Publication date: January 15, 2004Applicant: Integrated Biosystems, Inc.Inventors: David C. Brown, Jonathan Cutting, Eric K. Lee, Nicolas Voute, Brian J. Woodward
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Patent number: 6631616Abstract: A biopharmaceutical cryopreservation system includes a container having an outer surface area with the container being adapted to contain a biopharmaceutical material for freezing and thawing therein. The container may be received in a cryocooling enclosure having an interior cavity configured to receive it. The cryocooling enclosure includes at least one heat transfer surface configured to contact the outer surface area of the container when the cryocooling enclosure interior cavity receives the container. Also, a cryocooler is thermally coupled to the cryocooling enclosure and is configured to flow a fluid to the at least one heat transfer surface to control the temperature of the heat transfer surface and the biopharmaceutical material within the container. The fluid is isolated from contacting the container. Further, a temperature sensor is thermally coupled to the cryocooling enclosure, the at least one heat transfer surface, the fluid and/or the cryocooler.Type: GrantFiled: July 15, 2002Date of Patent: October 14, 2003Inventors: Richard Wisniewski, Eric K. Lee
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Publication number: 20030066295Abstract: A biopharmaceutical cryopreservation system includes a container having an outer surface area with the container being adapted to contain a biopharmaceutical material for freezing and thawing therein. The container may be received in a cryocooling enclosure having an interior cavity configured to receive it. The cryocooling enclosure includes at least one heat transfer surface configured to contact the outer surface area of the container when the cryocooling enclosure interior cavity receives the container. Also, a cryocooler is thermally coupled to the cryocooling enclosure and is configured to flow a fluid to the at least one heat transfer surface to control the temperature of the heat transfer surface and the biopharmaceutical material within the container. The fluid is isolated from contacting the container. Further, a temperature sensor is thermally coupled to the cryocooling enclosure, the at least one heat transfer surface, the fluid and/or the cryocooler.Type: ApplicationFiled: July 15, 2002Publication date: April 10, 2003Applicant: Integrated Biosystems, Inc.Inventors: Richard Wisniewski, Eric K. Lee
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Publication number: 20030062299Abstract: A high capacity leukocyte depletion filtration media incorporates a high specific surface area components with a matrix of fibers, yielding a filtration medium that removes leukocytes by at least 99.99%. The filtration medium uses a significantly low weight ratio of high specific surface area components to the matrix of fibers. The high specific area creates a multitude of adhesion sites for leukocytes while the low weight ratios allow good filtration flow rates. The filtration medium is incorporated into a filter device for removing leukocytes from biological fluids.Type: ApplicationFiled: October 23, 2002Publication date: April 3, 2003Applicant: Whatman Hemasure, Inc.Inventors: Eric K. Lee, Paul J. Vernucci, Samuel C. Williams
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Patent number: 6495039Abstract: An in-line biological liquid filtration system and method comprises a collection container for receiving biological liquid. A filter is located downstream of the collection container and in fluid flow communication therewith. A storage container for receiving filtered biological liquid is located downstream of the filter and the storage container is in fluid flow communication with the filter and with the collection container. An additive solution is located in the storage container. At least one automatic control member automatically restricts a flow of biological liquid or additive solution when flowing the liquid or solution between the collection container and the storage container.Type: GrantFiled: June 27, 2000Date of Patent: December 17, 2002Assignee: Whatman Hemasure, Inc.Inventors: Eric K. Lee, Franco Castino
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Publication number: 20020053548Abstract: A high capacity leukocyte depletion filtration media incorporates a high specific surface area components with a matrix of fibers, yielding a filtration medium that removes leukocytes by at least 99.99%. The filtration medium uses a significantly low weight ratio of high specific surface area components to the matrix of fibers. The high specific area creates a multitude of adhesion sites for leukocytes while the low weight ratios allow good filtration flow rates. The filtration medium is incorporated into a filter device for removing leukocytes from biological fluids.Type: ApplicationFiled: November 27, 2001Publication date: May 9, 2002Applicant: Whatman Hemasure Inc.Inventors: Eric K. Lee, Paul J. Vernucci, Samuel C. Williams
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Patent number: 6369394Abstract: An apparatus and method for illuminating a fluid having photosensitive material therein comprising a surface and a roller separated from the surface by a space. The space is adapted to receive a flexible container therein. The flexible container on the surface contacts the roller and the surface for translation through the space. A light source is adapted to transmit light to the space to illuminate the fluid and react with the photosensitive material as the flexible container translates through the space.Type: GrantFiled: February 26, 1999Date of Patent: April 9, 2002Assignee: Whatman Hemasure, Inc.Inventor: Eric K. Lee
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Patent number: 6337026Abstract: A high capacity leukocyte depletion filtration media incorporates a high specific surface area components with a matrix of fibers, yielding a filtration medium that removes leukocytes by at least 99.99%. The filtration medium uses a significantly low weight ratio of high specific surface area components to the matrix of fibers. The high specific area creates a multitude of adhesion sites for leukocytes while the low weight ratios allow good filtration flow rates. The filtration medium is incorporated into a filter device for removing leukocytes from biological fluids.Type: GrantFiled: March 8, 1999Date of Patent: January 8, 2002Assignee: Whatman Hemasure, Inc.Inventors: Eric K. Lee, Paul J. Vernucci, Samuel C. Williams
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Patent number: 6123859Abstract: An in-line biological liquid filtration system and method comprises a collection container for receiving biological liquid. A filter is located downstream of the collection container and in fluid flow communication therewith. A storage container for receiving filtered biological liquid is located downstream of the filter and the storage container is in fluid flow communication with the filter and with the collection container. An additive solution is located in the storage container. At least one automatic control member automatically restricts a flow of biological liquid or additive solution when flowing the liquid or solution between the collection container and the storage container.Type: GrantFiled: April 22, 1999Date of Patent: September 26, 2000Assignee: HemaSure Inc.Inventors: Eric K. Lee, Franco Castino
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Patent number: 5456835Abstract: A filter and a hollow-fiber or flat-sheet membrane for removing hemoglobin from whole blood or blood fractions are disclosed. The filter comprises a laid textile web which has been modified to attach a ligand for hemoglobin. The membrane comprises a polyethersulfone membrane that has been similarly modified. Methods for removing hemoglobin, cellular components and debris from blood are also disclosed.Type: GrantFiled: November 8, 1993Date of Patent: October 10, 1995Assignee: Hemasure, Inc.Inventors: Franco Castino, Abdul R. M. Azad, Eric K. Lee
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Patent number: 5143526Abstract: The method and apparatus of the present invention has general applicability to the manipulation of the concentration, by partial depletion or enrichment, of one or more volatile components in a given liquid while leaving the other volatile components in the liquid in a substantially undisturbed or unadulterated state.Type: GrantFiled: May 2, 1991Date of Patent: September 1, 1992Assignee: Sepracor, Inc.Inventors: Eric K. Lee, Vinay J. Kalyani, Stephen L. Matson
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Patent number: 5013447Abstract: The method and apparatus of the present invention has general applicability to the manipulation of the concentration, by partial depletion or enrichment, of one or more volatile components in a given liquid while leaving the other volatile components in the liquid in a substantially undisturbed or unadulterated state.Type: GrantFiled: January 10, 1990Date of Patent: May 7, 1991Assignee: SepracorInventors: Eric K. Lee, Vinay J. Kalyani, Stephen L. Matson