Abstract: A protein kinase that includes a donor molecule and an acceptor molecule, methods of making the protein kinase, and methods of using the protein kinase are described. Measurement of the conformation of the kinase can be obtained using intramolecular FRET. The protein kinase can be used to, for example, identify conformational changes involved in kinase regulation, that is, as an allostery sensor; to identify kinase-binding molecules including, for example, kinase inhibitors; to identify cancer therapeutics; or for high-throughput screening.

Abstract: A protein kinase that includes a donor molecule and an acceptor molecule, methods of making the protein kinase, and methods of using the protein kinase are described. Measurement of the conformation of the kinase can be obtained using intramolecular FRET. The protein kinase can be used to, for example, identify conformational changes involved in kinase regulation, that is, as an allostery sensor; to identify kinase-binding molecules including, for example, kinase inhibitors; to identify cancer therapeutics; or for high-throughput screening.

Abstract: The invention is directed to a full body coat, covering the body down to the wrists and ankles, but easily separable into a hooded jacket and a pair of pants. The jacket and pants are joined at the waist by a removable zipper, with the lower edge of the jacket overlapping the zipper to prevent heat loss. The wrist cuffs and ankle cuffs are both elastic and adjustable, to accommodate footwear and gloves of any size and thickness. The combined garment is water resistant, and designed to accommodate the most active user, with a full range of motion at the shoulders, hips, waist, elbows, and knees.