Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.

Abstract: A drumhead includes a membrane with ferrous responsive material printed onto a surface or otherwise incorporated into it. The ferrous responsive material is detectable by an electromagnetic sensor such that striking the membrane causes vibration that is detected by the sensor, which may initiate an acoustic sound via a sound module. The drumhead may thus be used in an electronic drumming system without requiring fixation of a foreign object to a surface of the membrane.

Abstract: Components for articles of footwear and athletic equipment are provided including a high energy return foam having improved abrasion resistance. A variety of foams and foam components and compositions for forming the foams are provided. In some aspects, the foams and components including the foams can have exceptionally high energy return while also having improved durability and softness and an improved abrasion resistance. In particular, midsoles including the foams are provided for use in an article of footwear. Methods of making the compositions and foams are provided, as well as methods of making an article of footwear including one of the foam components. In some aspects, the foams and foam components can be made by injection molding or injection molding followed by compression molding.

Abstract: Operating a gaseous fuel engine includes spark-igniting gaseous hydrogen fuel and air, and propagating combustion gases of the spark-ignited mixture outwardly from a spark gap. The propagating combustion gases are impinged upon a cone surface of a piston so as to limit a flame area of the propagating combustion gases. Additional gaseous hydrogen fuel and air is ignited in the combustion cylinder by way of the propagating combustion gases to urge a piston toward a bottom-dead-center position.

Abstract: Various implementations disclosed herein include devices, systems, and methods that provide customized feedback content during a meditation experience. For example, an example process may include obtaining physiological data via one or more sensors, determining that an attentive state based on the physiological data, customizing feedback content based on a user attribute to change the attentive state during the meditation mode, and providing the customized feedback content during the meditation mode after a delay time based on the user attribute.

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: Embodiments of system and methods for providing centralized management of a software defined automation (“SDA”) system are disclosed. The SDA system comprises of a collection of controller nodes and logically centralized and yet physically distributed collection of compute nodes by monitoring activities of the compute nodes. In accordance with some embodiments, one or more components of the system monitor execution, network and security environments of the system to detect an event in a first environment. In response to the detected event, at least one component in the first environment is remediated, the remediation of the first environment creating a trigger to cause remediation of at least one component in each of a second and third environments.

Abstract: A process of forming a sintered article includes heating a green portion of a tape of polycrystalline ceramic and/or minerals in organic binder at a binder removal zone to a temperature sufficient to pyrolyze the binder; horizontally conveying the portion of tape with organic binder removed from the binder removal zone to a sintering zone; and sintering polycrystalline ceramic and/or minerals of the portion of tape at the sintering zone, wherein the tape simultaneously extends through the removal and sintering zones.

Abstract: Mobile management method, system and client. Method includes receiving a DNS query for a host name from an application on client; retrieving reputation data associated with host name from a local cache on client; and determining a policy based on host name and the reputation data. Based on determined policy for the host name, blocking attempted network flows to a host corresponding to host name to produce blocked attempted network flows. Method also includes sending attempted network flow metadata related to the blocked attempted network flows to a collector on client; transmitting the attempted network flow metadata from the collector to a VPN server pool via a VPN tunnel; and producing an anomaly report from the transmitted attempted network flow metadata. The anomaly report includes at least one of anomalies, cohorts, trends, location boundaries, detected network security issues, detected compromised clients and/or optimized network usage.

Abstract: A semiconductor processing device is disclosed. The device can include a reactor and a solid source vessel configured to supply a vaporized solid reactant to the reactor. A process control chamber can be disposed between the solid source vessel and the reactor. The device can include a valve upstream of the process control chamber. A control system can be configured to control operation of the valve based at least in part on feedback of measured pressure in the process control chamber.

Abstract: A computer-implemented method for managing a contact center having a plurality of agents includes (a) receiving real-time data associated with each of a plurality of agents servicing incoming communications for the contact center, (b) categorizing each of the plurality of agents into a respective one of a plurality of burnout risk categories by processing the real-time data associated with each of the plurality of agents using a trained supervised machine learning model having a plurality of input features, (c) determining, based on a specification of a logical directive, an operation to be performed in relation to at least one agent in the plurality of agents, wherein the specification has at least one condition relating to the categorizing of each of the plurality of agents into the respective one of the plurality of burnout risk categories, and wherein the specification defines the operation to be performed in relation to the at least one agent in the plurality of agents upon the condition being satisfied,

Abstract: A discrete VRM card includes a first VRM controller and a second VRM controller. The discrete VRM card also includes a first primary power stage, a second primary power stage, and an adaptable spare stage. The discrete VRM card includes a first switch and a second switch. Closing the first switch connects the adaptable spare converter with an output of the first primary power stage. Closing the second switch connects the adaptable spare converter an output of the second primary power stage.

Abstract: A bed system includes microclimate control capabilities for providing quality sleep experience. The bed system can include a microclimate control subsystem configured to supply conditioned air (e.g., heated or cooled air) to a mattress, or draw ambient air from the mattress, to achieve a desired temperature at the top of the mattress. Utilizing supply of conditioned air to provide air at desired temperature to the mattress system, or utilizing air suction to drain heat away from the mattress system, can provide precise microclimate control at the mattress, thereby permitting conformable sleep.

Abstract: A chemical mechanical polishing pad includes a surface portion of a first material. The surface portion includes a plurality of grooves. A first portion of the grooves are exposed grooves located at a surface of the chemical mechanical polishing pad. A second portion of the grooves are buried grooves embedded below the surface of the chemical mechanical polishing pad, such that, during use of the chemical mechanical polishing pad, one or more of the buried grooves are exposed at the surface.

Abstract: Operating a gaseous fuel engine system includes combusting a mixture containing a gaseous hydrogen fuel and air in a cylinder of an engine, varying an operating parameter of the engine to which a crown surface temperature of a piston within the cylinder is responsive, and populating a temperature model based on a value of the varied operating parameter. Operating a gaseous fuel engine system further includes operating an oil spray apparatus to spray oil onto the piston based on the populated temperature model, and maintaining the crown surface temperature of the piston between a high temperature limit and a pre-ignition mitigation temperature limit based on the operating of the oil spray apparatus. Related apparatus and control logic is also disclosed.

Abstract: Computer-implemented methods and systems are provided for automatically performing a task on a remote computer. During a registration stage, the system receives personal information of a human user, obtains an IP address and a device configuration for a computing device, and stores the personal information, IP address, and the device configuration in record in a database. The system receives a request to interact with a remote website to perform a task, the request including the personal information of the human user. The system then retrieves the record from the database using the personal information. The system creates a virtual machine based on the device configuration for the computing device, selects one of a geographically distributed set of proxy servers having an IP geographically address resembling the IP address for the computing device, and executes instructions causing the virtual machine to interact with the remote website using the proxy server to perform the task.

Abstract: Reinforcement straps are used to hold a mattress system in place and keep it from bowing outwards when used. The mattress system can include a layer and a rail structure attached to the layer. The layer can have a layer top and a layer bottom opposite to the layer top. The layer can extend between a first layer edge and a second layer edge.

Abstract: An apparatus and method for an inspection apparatus for inspecting a component. The inspection apparatus including a robotic arm. A micro-XRF instrument having an instrument head coupled to the robotic arm. A seat supporting the component within a scanning area during inspection; and a computer in communication with the robotic arm and the micro-XRF instrument.

Abstract: A bed system includes microclimate control capabilities for providing quality sleep experience. The bed system can include a microclimate control subsystem configured to supply conditioned air (e.g., heated or cooled air) to a mattress, or draw ambient air from the mattress, to achieve a desired temperature at the top of the mattress. Utilizing supply of conditioned air to provide air at desired temperature to the mattress system, or utilizing air suction to drain heat away from the mattress system, can provide precise microclimate control at the mattress, thereby permitting conformable sleep.