Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: A wire length calculation system is provided for tracking wire stored on and drawn from a reel. The wire length calculation system may include a detection element, digital logic components, location receiver, enclosure, analytic components, interface component, and sensor module. One or more sensors relative to the reel may detect a position indicative of forward or reverse reel rotation. A processor may analyze signals to count rotations of the reel, which is savable in memory. A battery may provide power. The system may also record the time and location associated with rotations. A method for tracking wire stored on and drawn from a reel using a wire length calculation system is also provided.

Abstract: A modular material tracking system is provided for tracking material stored on and drawn from a reel using a modular system. The modular material tracking system may include a detection element, digital logic components, location receiver, enclosure, analytic components, interface component, sensor module, and plate module. One or more sensors relative to the reel may detect a position indicative of forward or reverse reel rotation. A processor may analyze signals to count rotations of the reel, which is savable in memory. A battery may provide power. The system may also record the time and location associated with rotations. A method for tracking material stored on and drawn from a reel using a modular material tracking system is also provided.

Abstract: A holder is described. The holder is for a sample vial and includes a base and a cap, where the holder and cap include one or more materials that are opaque or optically black. The holder includes an interior space for placement of the vial in a light-tight environment, where the holder cap includes an opening for insertion of a probe therethrough and into the sample vial. The disclosure also includes systems and methods using the holder.

Abstract: A process for treating a wastewater stream includes delivering a wastewater stream to an attached growth reactor to provide an amount of activated carbon and an attached growth support media having active biological material thereon within the attached growth reactor. The method also includes contacting the wastewater stream with attached growth support media and the activated carbon with the attached growth reactor to reduce an amount of biodegradable and adsorbable contaminants in the wastewater stream.

Abstract: A method for transferring a spacecraft (10), such as an artificial satellite, from an initial elliptical orbit (30) to a final geostationary orbit (50), the spacecraft taking at least one intermediate elliptical orbit (40) propelled by electric propulsion means (12, 13), the method includes: when the spacecraft is in an intermediate orbit, a nominal thrust step (410) in which the propulsion means generate nominal thrust while the spacecraft is on at least part of a first orbital arc (41) passing through the apogee A of the intermediate orbit, and a minimum thrust step (420), in which the propulsion means are partly stopped or slowed while the spacecraft is on at least part (43) of a second orbital arc (42) passing through the perigee P of the intermediate orbit, the two orbital arcs being complementary.

Abstract: A glass hollow container including a finish intended to cooperate with a cap with notches to close the container, wherein the finish has a locking ring whose cross section has a profile substantially in the shape of an ogive.

Abstract: A modular material tracking system is provided for tracking material stored on and drawn from a reel using a modular system. The modular material tracking system may include a detection element, digital logic components, location receiver, enclosure, analytic components, interface component, sensor module, and plate module. One or more sensors relative to the reel may detect a position indicative of forward or reverse reel rotation. A processor may analyze signals to count rotations of the reel, which is savable in memory. A battery may provide power. The system may also record the time and location associated with rotations. A method for tracking material stored on and drawn from a reel using a modular material tracking system is also provided.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: Systems, devices and methods adaptable for use with or as a toilet seat to assist in a bowel movement. The systems and devices may include one or more projections extending upward to be desirably positioned relative to body parts while the user is seated on a toilet seat having the one or more projections.

Abstract: Provided herein are inhibitors of GPX4, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the GPX4 inhibitory compounds for the modulation of ferroptosis and treatment of disease.

Abstract: A holder is described. The holder is for a sample vial and includes a base and a cap, where the holder and cap include one or more materials that are opaque or optically black. The holder includes an interior space for placement of the vial in a light-tight environment, where the holder cap includes an opening for insertion of a probe therethrough and into the sample vial. The disclosure also includes systems and methods using the holder.

Abstract: An apparatus for scattering light may include: an optical fiber having a first length; and a sleeve, having a second length shorter than the first length, around the optical fiber. The optical fiber may include: a core; and cladding around the core. The sleeve may include fiber-optic material. The fiber-optic material may be substantially polymer-free. An outer surface of the sleeve may be roughened to scatter the light out of the sleeve through the roughened surface. A method of forming an apparatus for scattering light may include: providing a sleeve having a first length, the sleeve having inner and outer surfaces; providing an optical fiber having a second length longer than the first length; passing the sleeve around the optical fiber or threading the optical fiber through the sleeve; and roughening at least a portion of the outer surface of the sleeve.

Abstract: In one example in accordance with the present disclosure, a fluidic die is described. The fluidic die includes an array of fluid actuators grouped into primitives. The fluidic die also includes a fluid actuator controller to selectively activate fluid actuators via activation data. The fluidic die also includes an array of actuator evaluators, wherein each actuator evaluator of the fluidic die is coupled to a subset of the array of fluid actuators. The actuator evaluators selectively evaluate an actuator characteristic of a selected fluid actuator based on: an output of an actuator sensor paired with the selected fluid actuator, the activation data, and an evaluation control signal.

Abstract: Apparatus include a first laser diode situated to emit a beam from an exit facet along an optical axis, the beam as emitted having perpendicular fast and slow axes perpendicular to the optical axis, a first fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the first laser diode, a second laser diode situated to emit a beam from an exit facet of the second laser diode along an optical axis parallel to the optical axis of the first laser diode and with a slow axis in a common plane with the slow axis of the first laser diode, and a second fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet of the second laser diode and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the second laser diode.

Abstract: According to an example, a method for performing maintenance routines in a plurality of actuators comprises firing a set of actuators at different energies, determining turn on energy values for the set of actuators based on measurements measured via chamber sensors associated with the set of actuators at the different energies, determining turn on energy differences for the set of actuators based on the turn on energy values determined for the set of actuators and threshold turn on energy values associated with the set of actuators, and performing maintenance routines corresponding to the determined turn on energy differences.

Abstract: A holder is described. The holder is for a sample vial and includes a base and a cap, where the holder and cap include one or more materials that are opaque or optically black. The holder includes an interior space for placement of the vial in a light-tight environment, where the holder cap includes an opening for insertion of a probe therethrough and into the sample vial. The disclosure also includes systems and methods using the holder.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: A temporary-storage system that includes a temporary-storage belt, a control unit and signalling means. The temporary-storage belt comprises a plurality of regularly distributed sensors. During a loading phase, the control unit receives information coming from at least one of the sensors when an object is deposited on the temporary-storage belt and records a trace of the deposition of the object in association with a reference to each of the sensors activated by the deposition. During an unloading phase, the control unit determines a sequence of removal of the objects and, for each object to be removed, identifies the sensors referenced, transmits to the signalling means signalling information identifying the position of the object, and receives information coming from at least one of the sensors when the object is removed.

Abstract: Various embodiments provide apparatuses, systems, and methods related to a dual-sided optical package. The package may include a base plate with a first side and a second side opposite the first side. The base plate may have a coolant channel positioned between the first side and the second side. A first set of optics may be coupled with the first side of the base plate, and a second set of optics may be coupled with the second side of the base plate. Other embodiments may be described and/or claimed.