Patents by Inventor Eric R. Ward
Eric R. Ward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5880328Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: March 9, 1999Assignee: Novartis Finance CorporationInventors: John A. Ryals, Eric R. Ward, George B. Payne, Mary B. Moyer, Frederich Meins, Jr.
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Patent number: 5856154Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: January 5, 1999Assignee: Novartis Finance CorporationInventors: John A. Ryals, Danny C. Alexander, Robert M. Goodman, Eric R. Ward
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Patent number: 5847258Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: December 8, 1998Assignee: Novartis Finance CorporationInventors: John A. Ryals, Mary B. Moyer, George B. Payne, Eric R. Ward
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Patent number: 5804693Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: September 8, 1998Assignee: Novartis Finance CorporationInventors: Thomas D. Gaffney, John A. Ryals, Leslie B. Friedrich, Scott J. Uknes, Eric R. Ward, Helmut Kessmann, Bernardus T. Vernooij
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Patent number: 5792904Abstract: Methods are provided for selecting parental plants having disease resistance and for using these plants in breeding programs. In one method of the invention, lesion mimic mutants are screened for either resistance to a pathogen of interest or for the expression of systemic acquired resistance (SAR) genes. Such mutants having the desired traits or expressing the desired genes are then used in breeding programs. Parent plants can also be selected based on the constitutive expression of SAR genes. These mutants are phenotypically normal yet exhibit a significant level of disease resistance. Also disclosed are plant mutants that do not express systemic acquired resistance genes even when induced by a pathogen and methods of use for such mutants.Type: GrantFiled: May 16, 1996Date of Patent: August 11, 1998Assignee: Novartis Finance CorporationInventors: John A. Ryals, Scott J. Uknes, Terrence Patrick Delaney, Eric R. Ward, Henry-York Steiner
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Patent number: 5789214Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: August 4, 1998Assignee: Novartis Finance CorporationInventors: John A. Ryals, Leslie B. Friedrich, Scott J. Uknes, Eric R. Ward
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Patent number: 5767373Abstract: The present invention provides novel eukaryotic DNA sequences coding for native protoporphyrinogen oxidase (protox) or modified forms of the enzyme which are herbicide tolerant. Plants having altered protox activity which confers tolerance to herbicides are also provided. These plants may be bred or engineered for resistance to protox inhibitors via mutation of the native protox gene to a resistant form or through increased levels of expression of the native protox gene, or they may be transformed with modified eukaryotic or prokaryotic protox coding sequences or wild type prokaryotic protox sequences which are herbicide tolerant. Diagnostic and other uses for the novel eukaryotic protox sequence are also described. Plant genes encoding wild-type and altered protox, purified plant protox, methods of isolating protox from plants, and methods of using protox-encoding genes are also disclosed.Type: GrantFiled: June 6, 1995Date of Patent: June 16, 1998Assignee: Novartis Finance CorporationInventors: Eric R. Ward, Sandra Volrath
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Patent number: 5712382Abstract: The present invention provides novel plant DNA sequences coding for native adenylosuccinate lyase (ADSL). Methods for using the complete or partial ADSL coding sequence as a probe for diagnostic, mapping and other purposes are taught. Generation of transformed host cells capable of expressing ADSL is also taught. Methods of using the transformed host cells are taught, including methods for recombinant production of ADSL enzymes. A method for using the plant ADSL enzyme to screen for inhibitors of ADSL activity is also provided.Type: GrantFiled: October 26, 1995Date of Patent: January 27, 1998Assignee: Novartis Finance CorporationInventors: Charles David Guyer, Eric R. Ward
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Patent number: 5689044Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 24, 1995Date of Patent: November 18, 1997Assignee: Novartis CorporationInventors: John A. Ryals, Leslie B. Friedrich, Scott J. Uknes, Eric R. Ward
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Patent number: 5688939Abstract: The present invention provides novel plant DNA sequences coding for native adenylosuccinate synthetase (ADSS). Methods for using the complete or partial ADSS coding sequence as a probe for diagnostic, mapping and other purposes are taught. Generation of transformed host cells capable of expressing ADSS is also taught. Methods of using the transformed host cells are taught, including methods for recombinant production of ADSS enzymes. A method for using the plant ADSS enzyme to screen for inhibitors of ADSS activity is also provided.Type: GrantFiled: November 29, 1995Date of Patent: November 18, 1997Assignee: Novartis Finance CorporationInventors: Sharon Lee Potter, Eric R. Ward
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Patent number: 5650505Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 24, 1995Date of Patent: July 22, 1997Assignee: Novartis CorporationInventors: John A. Ryals, Danny C. Alexander, James J. Beck, John H. Duesing, Robert M. Goodman, Leslie B. Friedrich, Christian Harms, Frederich Meins, Jr., Alice Montoya, deceased, Mary B. Moyer, Jean-Marc Neuhaus, George B. Payne, Christoph Sperisen, Jeffrey R. Stinson, Scott J. Uknes, Eric R. Ward, Shericca C. Williams
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Patent number: 5614395Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: January 13, 1994Date of Patent: March 25, 1997Assignee: Ciba-Geigy CorporationInventors: John A. Ryals, Danny C. Alexander, James J. Beck, John H. Duesing, Robert M. Goodman, Leslie B. Friedrich, Christian Harms, Frederich Meins, Jr., Alice Montoya, deceased, Mary B. Moyer, Jean-Marc Neuhaus, George B. Payne, Christoph Sperisen, Jeffrey R. Stinson, Scott J. Uknes, Eric R. Ward, Shericca C. Williams
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Patent number: 5541310Abstract: Disclosed are plants, plant tissue and plant seed, whose growth and development are tolerant of, or resistant to various imidazole and triazole herbicidal compounds, at levels which normally are inhibitory to the plants. The tolerance or resistance is conferred by an altered imidazoleglycerol phosphate dehydratase (IGPD). Plant genes encoding wild-type and altered IGPD, purified plant IGPD, methods of isolating IGPD from plants, and methods of using both purified IGPD and IGPD-encoding genes are also disclosed.Type: GrantFiled: April 29, 1994Date of Patent: July 30, 1996Assignee: Ciba-Geigy CorporationInventors: Eric R. Ward, Sandra Volrath, Shinichi Koizumi, Sachiyo Tada, Ichiro Mori, Genji Iwasaki
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Patent number: 5519125Abstract: The present invention provides novel plant DNA sequences coding for native adenylosuccinate synthetase (ADSS). Methods for using the complete or partial ADSS coding sequence as a probe for diagnostic, mapping and other purposes are taught. Generation of transformed host cells capable of expressing ADSS is also taught. Methods of using the transformed host cells are taught, including methods for recombinant production of ADSS enzymes. A method for using the plant ADSS enzyme to screen for inhibitors of ADSS activity is also provided.Type: GrantFiled: December 22, 1994Date of Patent: May 21, 1996Assignee: Ciba-Geigy CorporationInventors: Sharon L. Potter, Eric R. Ward
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Patent number: 5290926Abstract: The present invention comprises cDNA coding for histidinol dehydrogenase from plants, the final step in histidine biosynthesis. The invention also comprises a novel method of purifying histidinol dehydrogenase from plants to essential honogeneity, the purified histidinol dehydrogenase, an assay for identifying inhibitors of histidinol dehydrogenase, an assay to identify mutants of histidinol dehydrogenase that are not inhibited by inhibitors of wild-type histidinol dehydrogenase, the inhibitors so identified as well as herbicide compositions containing them, the non-inhibited mutants of histidinol dehydrogenase, transgenic crop plants containing the non-inhibited mutants of histidinol dehydrogenase, and methods of treating weeds utilizing the application of histidinol dehydrogenase inhibitors to the transgenic crops containing the non-inhibited mutants of histidinol dehydrogenase.Type: GrantFiled: September 14, 1990Date of Patent: March 1, 1994Assignee: Ciba-Geigy CorporationInventors: Alfred Scheidegger, Eric R. Ward, John A. Ryals, Atsuko Nagai-Hayashi