Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: In one aspect, a mass spectrometer is disclosed, which comprises an ion trap having a plurality of electrodes arranged in a multipole configuration so as to provide an inlet for receiving ions along a longitudinal axis into a space between the electrodes, where at least one of the plurality of electrodes comprises a passageway through which ions can be extracted radially from the ion trap. The electrodes are configured for application of one or more RF voltages thereto for providing radial confinement of the ions, and a DC voltage source configured to apply a dipolar DC voltage pulse across said at least one electrode and an opposed electrode for causing radial extraction of at least a portion of said ions from said ion trap through said passageway.

Abstract: Provided herein are methods of treatment including methods of treating cancer and methods of enhancing an anti-tumoral activity of a bispecific T-cell engager (BiTE) or of a bispecific antibody. The methods disclosed herein include activating T-cells and contacting activated T-cells with BiTEs or bispecific antibodies for administration to a subject.

Abstract: A method of generating customizable goal representation is disclosed. A request from a user to view a goal representation is received. A flexible goal ontology is accessed that comprises one or more goal entities, one or more goal relationships between the goal entities, or one or more goal properties, the one or more goal properties including one or more metadata attributes relating to the one or more goal entities. A set of mapping rules is obtained that defines mappings between one or more goals. The set of mapping rules is evaluated to assemble a customized goal representation tailored to the user. The customized goal representation is updated based on a revaluation of the mapping rules affected by changes to the one or more goal entities, the one or more goal relationships, or the one or more properties.

Abstract: Fibrous structures, for example sanitary tissue products, such as toilet tissue, and more particularly fibrous structures containing a movable surface and methods for making same and methods for making same are provided.

Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.

Abstract: A surgical clip applier includes a handle assembly, an elongated shaft, a drive shaft, a cam pin, and an end effector. The cam pin is disposed in mechanical cooperation with the drive shaft. The end effector is disposed adjacent a distal end of the elongated shaft and includes a first jaw member and a second jaw member. The end effector is disposed in operative engagement with the drive shaft such that longitudinal translation of the drive shaft relative to the housing of the handle assembly causes the first jaw member to move toward the second jaw member. The first jaw member includes a first cam slot configured to slidingly receive the cam pin. The first cam slot defines a first portion having a first slope and a second portion having second slope.

Abstract: A header for an agricultural harvester including an endless belt conveyor and a flex arm disposed between upper and lower runs of the endless belt conveyor. The flex arm includes an elongate beam having an upper surface, and a roller extending above the upper surface of the elongate beam for contacting the upper run of the endless belt conveyor. The roller raises the belt conveyor above the upper surface of the elongate beam, thereby minimizing contact between the upper run of the endless belt conveyor and friction reducing bearings situated atop channel supports connected at opposite sides of the elongate beam. The resultant construction minimizes wear, heat and drag on the endless belt conveyor and the friction reducing bearings.

Abstract: Data processing apparatuses, methods of data processing, complementary instructions and programs related to ring buffer administration are disclosed. An enqueuing operation performs an atomic compare-and-swap oper-ation to store a first processed data item indication to an enqueuing-target slot in the ring buffer contingent on an in-order marker not being present there and, when successful, determines that a ready-to-dequeue condition is true for the first processed data item indication. A dequeuing operation, when the ready-to-de-queue condition for a dequeuing-target slot is true, comprises writing a null data item to the dequeuing-target slot and, when dequeuing in-order, further comprises, dependent on whether a next contiguous slot has null content, determining a retirement condition and, when the retirement condition is true, performing a retirement process on the next contiguous slot comprising making the next con-tiguous slot available to a subsequent enqueuing operation.

Abstract: A welding helmet system is provided. The welding helmet system includes a protective shell and a welding display system. The welding display system is configured to be removably coupled to the protective shell. The welding display system is configured to receive data from a sensor, and to display a welding metric derived from the sensor via the image generation system.

Abstract: Various embodiments provide systems and methods for live action gaming. According to one embodiment, a method facilitates scoring for an in-person, live-action game, for example, a projectile-tag scoring game or the like, involving multiple players. A gaming outfit worn by a first player or a projectile launcher of a second player may determine a shot hit by the second player against the first player based at least in part on detection of an impact of a projectile fired by the projectile launcher with the gaming outfit. A score for the in-person, live-action game may then be updated based on the shot hit.

Abstract: According to examples, an apparatus may include a fluidic chamber, in which fluid is to be temporarily held. The apparatus may also include a heating component to generate heat to form a drive bubble in the fluid held in the fluidic chamber and a cavitation plate may be provided between the fluidic chamber and the heating component. The cavitation plate may be in communication with the fluidic chamber and may physically separate the fluidic chamber from the heating component to protect the heating component. In addition, a controller may determine a condition in the fluidic chamber based on an electrical signal received from the cavitation plate.

Abstract: Systems and methods are disclosed for ion injection into an electrostatic trap. As non-limiting examples, various aspects of this disclosure provide a quadrupole comprising first, second, and third quadrupole segments. The second quadrupole segment may be arranged between the first and third quadrupole segments and the first quadrupole segment and the third quadrupole segment may each comprise four poles with auxiliary electrodes arranged between each pair of the four poles. The second quadrupole segment may comprise four poles and the first and third quadrupoles each may comprise four individual auxiliary electrodes, two pairs of auxiliary electrodes, two electrodes, or one pair of auxiliary electrodes. The auxiliary electrodes of the first quadrupole segment and the entrance lens may be biased at a same direct current (DC) voltage. The auxiliary electrodes of the third quadrupole segment and the exit lens may be biased at a same DC voltage.

Abstract: Systems and methods are disclosed for ion injection into an electrostatic trap. Various aspects of this disclosure provide a mass spectrometer system including a primary ion path including a plurality of quadrupoles; and a secondary ion path coupled to the primary ion path utilizing turning elements. The secondary ion path may include an electrostatic linear ion trap (ELIT), the ELIT being operable to analyze ions diverted from the primary ion path and return them to the primary ion path. The primary ion path may include a time-of-flight mass analyzer. The secondary ion path may be bi-directional. Ions may travel in a first direction when coupled into the secondary ion path using a first turning element in the primary ion path and may travel in a second direction when coupled into the secondary ion path utilizing a second turning element in the primary ion path. The secondary ion path may include a collision quadrupole.

Abstract: An example of an apparatus is provided. The apparatus includes a printhead to dispense drops of print fluid on a media. The drops are to travel along a drop path through air from the printhead. In addition, the apparatus includes a light source to emit light across the drop path. The apparatus also includes a detector to detect an intensity of the light received from the light source. The drop path is to intersect an optical path from the light source to the detector. Furthermore, the apparatus includes a coating disposed on the optical path between the drop path and the detector. The coating is to absorb a threshold amount of the light.

Abstract: A shroud retention system may include a retainer plate holder having a top surface, a bottom surface parallel to the top surface, a retainer plate engaging surface extending between the bottom surface and the top surface, wherein the retainer plate engaging surface may be inclined relative to a plane perpendicular to the top surface, a rear surface opposite the retainer plate engaging surface, a through-hole intersecting the retainer plate engaging surface and the rear surface and one or more protrusions extending from the retainer plate engaging surface.

Abstract: One example of a fluidic die includes a power supply node, a plurality of fluidic actuators, a plurality of discharge circuits, and a single discharge enable signal path. The plurality of fluidic actuators are electrically coupled to the power supply node. The plurality of discharge circuits are electrically coupled to the power supply node. The single discharge enable signal path is electrically coupled to each discharge circuit of the plurality of discharge circuits to enable each discharge circuit of the plurality of discharge circuits in parallel.

Abstract: A Fourier Transform electrostatic linear ion trap (ELIT) is disclosed with an electron multiplier detector comprising one of a microchannel plate and a channel electron multiplier. An (ELIT) is provided comprising a central axis along which ions travel; an image current detector disposed at least partially around the central axis of the ELIT; and an electron multiplier detector arranged in an opening of the image current detector, the electron multiplier detector being operable to receive ions deflected from the central axis. The electron multiplier detector may have a front surface that is perpendicular to the central axis of the ELIT. The electron multiplier detector may comprise two separate elements at non-normal angles to the central axis of the ELIT. The image current detector may comprise a cylinder with the opening on one side in which the electron multiplier detector is arranged, a U-shape, or a half-tube detector.