Abstract: A system and method for calibrating a forward-facing camera or sensor of a vehicle is provided. The system includes a calibration tool, the position of which can be adjusted on the vehicle to align a presentation screen of the calibration tool with the vehicle camera. A processor performs a method to determine the size and position of a calibration target to be displayed on the presentation screen, based on a position of the calibration tool relative to the vehicle camera and generates a calibration target image to be digitally transmitted to the presentation screen. The presentation screen displays the calibration target image at an appropriate height, angle, and distance from the camera or sensor being calibrated.

Abstract: A mass spectrometer is operated to simultaneously measure precursor and production data over a number of acquisitions. For each acquisition, the following steps are performed. Ion transfer optics inject ions from an ion beam into an ELIT causing the ions to oscillate axially between two electric fields produced by two the sets of reflectrons. The ELIT measures a time domain image current of the oscillating ions from ion injection to a total acquisition time, Tacq1, and fragments the oscillating ions at one or both turning points of the oscillating ions adding product ions to the oscillating ions. The fragmentation is performed at a delay time relative to the ion injection that is increased by a time increment in each subsequent acquisition making the fragmentation dependent on ion position. The measured time domain image current is stored as a row or column of a two-dimensional matrix.

Abstract: The present disclosure is directed to methods and apparatus for centralized de-identification of protected data associated with subjects. In various embodiments, de-identified data may be received (1102) that includes de-identified data set(s) associated with subject(s) that is generated from raw data set(s) associated with the subjects. Each of the raw data set(s) may include identifying feature(s) that are usable to identify the respective subject. At least some of the identifying feature(s) may be absent from or obfuscated in the de-identified data. Labels associated with each of the de-identified data sets may be determined (1104). At least some of the de-identified data sets may be applied (1108) as input across a trained machine learning model to generate respective outputs, which may be compared (1110) to the labels to determine a measure of vulnerability of the de-identified data to re-identification.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: One or more ions are received along a central axis through a first set of reflectron plates of an ELIT. Voltages are applied to the first set of plates and to a second set of reflectron plates in order to trap and oscillate the one or more ions. A first induced current is measured from a cylindrical pickup electrode between the first set of reflectron plates and the second set of reflectron plates. A second induced current is measured from one or more plates of the first set of reflectron plates. A third induced current is measured from one or more plates of the second set of reflectron plates. The first measured induced current, second measured induced current and third measured induced current are combined to reduce higher order frequency harmonics of the induced current.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.

Abstract: A method for the additive manufacturing of a component includes providing a powdered base material for a component, in particular a component for the hot gas path of a gas turbine, building up the component layer by layer on a building platform by fusing individual layers of the base material, and introducing an oxide dispersion strengthening into a region of the component to be additively manufactured by an oxidic additive, wherein the region is usually exposed to high thermomechanical loading during operation of the component.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: A mass spectrometer is operated to simultaneously measure precursor and production data over a number of acquisitions. For each acquisition, the following steps are performed. Ion transfer optics inject ions from an ion beam into an ELIT causing the ions to oscillate axially between two electric fields produced by two the sets of reflectrons. The ELIT measures a time domain image current of the oscillating ions from ion injection to a total acquisition time, Tacq1, and fragments the oscillating ions at one or both turning points of the oscillating ions adding product ions to the oscillating ions. The fragmentation is performed at a delay time relative to the ion injection that is increased by a time increment in each subsequent acquisition making the fragmentation dependent on ion position. The measured time domain image current is stored as a row or column of a two-dimensional matrix.

Abstract: The present disclosure provides systems and methods that allow a first user to anchor a virtual object to a physical location and a second user to view the virtual object at the physical location. In particular, aspects of the present disclosure are directed to workflows, application programming interfaces (“APIs”), and computing system infrastructure that enable a first computing device to generate an ad hoc mapping of its physical surroundings (e.g., based on sensor data collected by the first device) and to position and anchor a virtual object at a physical location within such mapping. Data descriptive of the mapping and virtual object can be stored in a cloud database and can then be used by or for a second device to render the virtual object at the location of the anchor.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract: Compounds that are inhibitors of at least one of the ARG1 and ARG2, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by ARG1 and ARG2 are also described herein.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: One or more ions are received along a central axis through a first set of reflectron plates of an ELIT. Voltages are applied to the first set of plates and to a second set of reflectron plates in order to trap and oscillate the one or more ions. A first induced current is measured from a cylindrical pickup electrode between the first set of reflectron plates and the second set of reflectron plates. A second induced current is measured from one or more plates of the first set of reflectron plates. A third induced current is measured from one or more plates of the second set of reflectron plates. The first measured induced current, second measured induced current and third measured induced current are combined to reduce higher order frequency harmonics of the induced current.

Abstract: Various systems and processes may achieve mobile imaging. In particular implementations, systems and processes for mobile imaging may include the ability to capture video data with a number of video cameras mounted on a vehicle, determine positioning information as the cameras capture video data, and place audio marks in the video data of each camera. Each camera may be positioned to obtain a different view relative to the vehicle and adapted to capture video data as the vehicle travels. The positioning information may, for example, be derived from a global positioning system transceiver. The audio marks may be generated a number of times as the vehicle travels, and the time for each activation logged. The captured video data from each camera may be synchronized based on the audio marks and then combined to generate a 360 degree video, as well as related images, which may be correlated with map locations.

Abstract: An example oven can include: a main body with a cooking cavity; a front portion of the main body having a front opening for receiving a pizza and acting as an air vent; a wood burning tray assembly including a grate positioned in the main body; and a gas burner positioned adjacent to the wood burning tray assembly; wherein the gas burner is configured to combust a gas to heat the cooking cavity; and wherein the gas burner is positioned to ignite wood on the grate of the wood burning tray assembly to further heat the cooking cavity.

Abstract: The disclosure is directed to an apparatus and system for adjusting rate of spool centering in a pilot-controlled hydraulic spool valve. The apparatus includes a first pilot port and a second pilot port. The apparatus includes a first valve port and a second valve port. The apparatus also includes a first hydraulic circuit connecting the first pilot port and the first valve port, wherein the first hydraulic circuit, based on a hydraulic fluid pressure of the second pilot port, comprises one of a controlled-flow condition and an unrestricted-flow condition. The apparatus further includes a second hydraulic circuit connecting the second pilot port and the second valve port, wherein the second hydraulic circuit, based on a hydraulic fluid pressure of the first pilot port, comprises one of a controlled-flow condition and an unrestricted-flow condition.

Abstract: A system and method for calibrating a forward-facing camera or sensor of a vehicle is provided. The system includes a calibration tool, the position of which can be adjusted on the vehicle to align a presentation screen of the calibration tool with the vehicle camera. A processor performs a method to determine the size and position of a calibration target to be displayed on the presentation screen, based on a position of the calibration tool relative to the vehicle camera and generates a calibration target image to be digitally transmitted to the presentation screen. The presentation screen displays the calibration target image at an appropriate height, angle, and distance from the camera or sensor being calibrated.