Abstract: Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein the dashed line, X, R1, R2, R3, R4, R5, R6, and R7 have defined meanings; the preparation thereof; compositions containing compounds of formula (I), including bioavailable combinations with ritonavir; and the pharmaceutical uses thereof.

Abstract: A tactile sensor includes a flexible medium having electrically conductive strips embedded therein and extending in a first direction, said electrically conductive strips including conductive nanostructures dispersed in a flexible support material, said nanostructures selected from conductive nanowires, carbon nanotubes, and graphene, wherein each electrically conductive strip is connected at each end to an impedance measuring device that measures the impedance across each electrically conductive strip. The electrically conductive strips may be formed on a first layer of the flexible medium by using direct-write technology.

Abstract: The biological test kit is a device for drawing and, optionally, testing biological samples. The biological test kit is an array of lancets set in wells in a rigid base. Each lancet well is covered by a protective cover which when deformed permits the lancet to puncture a user or other patient. In one embodiment the biological test kit employs distinct covers for each lancet and in another the covers are formed from sheet material formed into blisters which cover the lancet.

Abstract: Presentation of accessible content is in accordance with a grid established by rules independent of the content. Different rules establish different grids utilizable with the same content, thereby enabling proper formatting across a wide range of devices and displays. The rules provide for fixed size and auto sized column widths and row heights. Additionally, the rules provide for column widths and row heights size based on fractional weighting of the remaining space after the fixed size and auto sized grid members are accounted for. The grid establishes a coordinate system onto which content is “hung” by aligning an aspect of the content with a coordinate point. Content is hung by reference to its beginning, its end, its center point, or, alternatively, content can be specified to be stretched to fit the width of the column and the height of the row with which it is associated.

Abstract: The biological test kit is a device for drawing and, optionally, testing biological samples. The biological test kit is an array of Lancets set in wells in a rigid base. Each lancet well is covered by a protective cover which when deformed permits the lancet to puncture a user or other patient. In one embodiment the biological test kit employs distinct covers for each lancet and in another the covers are formed from sheet material formed into blisters which cover the lancet.

Abstract: A nerve growth chamber includes a stimulation vessel defined by one or more sidewalls; at least one anode and at least one cathode positioned in the sidewall or sidewalls of the stimulation vessel; a conductive medium in the stimulation vessel; nerve tissue in the stimulation vessel; and a signal generator connecting the at least one anode and the at least one cathode and activated to generate a periodic AC signal at a desired frequency and amplitude, the periodic AC signal traveling through the conductive medium and affecting the growth of the nerve tissue. A method in accordance with the operation of the apparatus is also provided.

Abstract: An apparatus in an example comprises a manipulator, a force sensor, a signal modulator, and a visual indicator. The manipulator is employed by a user. The force sensor determines a force signal from a force applied by the manipulator on a part of an environment of the user. The signal modulator is adjustable by the user to select a switch point for the visual indicator based on relative fragility of the part of the environment. The signal modulator employs the force signal and the switch point to control the visual indicator for the user.

Abstract: The present invention relates to compositions, assay devices, kits and methods for detecting the presence, amount and/or activity of an analyte in a sample. In particular, the present invention relates to the detection of enzymes. The present invention also relates to methods of diagnosing diseases associated with dysregulation of enzymes, screening for modulators of enzymatic activity, candidate antimicrobial peptides and toxins.

Abstract: Compounds of the formula I: including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof; useful as HCV inhibitors; processes for preparing these compounds as well as pharmaceutical compositions comprising these compounds as active ingredient.

Abstract: Techniques involving dynamic colorization of graphical user interfaces. One representative technique includes enabling a user to specify colors in which user interface elements will be colored in an application. An application colorization service is initiated in response to the user specification of the colors, which is used at least to obtain the colors specified by the user, and to create bitmap images of the application's user interface elements using the user-specified colors. A bitmap image output location is made accessible to the application to enable the application to retrieve the created bitmap images, and present the application using the application user interface elements having the user-specified colors.

Abstract: Presentation of accessible content is in accordance with a grid established by rules independent of the content. Different rules establish different grids utilizable with the same content, thereby enabling proper formatting across a wide range of devices and displays. The rules provide for fixed size and auto sized column widths and row heights. Additionally, the rules provide for column widths and row heights size based on fractional weighting of the remaining space after the fixed size and auto sized grid members are accounted for. The grid establishes a coordinate system onto which content is “hung” by aligning an aspect of the content with a coordinate point. Content is hung by reference to its beginning, its end, its center point, or, alternatively, content can be specified to be stretched to fit the width of the column and the height of the row with which it is associated.

Abstract: The biological test kit is a device for drawing and, optionally, testing biological samples. The biological test kit is an array of Lancets set in wells in a rigid base. Each lancet well is covered by a protective cover which when deformed permits the lancet to puncture a user or other patient. In one embodiment the biological test kit employs distinct covers for each lancet and in another the covers are formed from sheet material formed into blisters which cover the lancet.

Abstract: An apparatus for cleaning and extracting water from carpet, comprising a vacuum head including a vacuum chamber configured to be connected to a vacuum source and two downward facing elongate vacuum ports extending downwardly from the vacuum chamber and an elongate solution manifold mounted between the vacuum ports and configured to discharge cleaning liquid in a space between the vacuum ports. The vacuum ports are configured to extract waste liquid from carpet when the vacuum head is moved in both a forward motion and a backward motion of the vacuum head. Further, the vacuum head includes elongate glides sealingly fitted in lower openings of the vacuum ports, the glides having suction openings formed therein through which fluids may be drawing into the vacuum ports, and the glides project below the bottom face of the vacuum head.

Abstract: An expansion device for breaking solid materials, including at least one hose element having an inner expansion chamber with a non-circular cross section before pressurization or having an inner pressuring means and/or a reinforcement arranged on the outside of the inner expansion chamber which has a non-circular cross section before pressurization. The inner pressuring means is arranged around the inner expansion chamber and the reinforcement is arranged around the inner pressuring means. Optionally an outer layer is arranged around the reinforcement, having at least one “directional-breaking-force amending” material portion which is arranged outside the reinforcement. The at least one hose element has a coupling connection on a first end of the hose element, and optionally a second coupling connection on a second end of the hose element.

Abstract: Systems and methods for conducting a virtual test market are disclosed. A system may include a virtual launch component, a transaction component, and a marketing simulation component. The components of the system may be used in combination to obtain, and analyze marketing data relating to a new product offering at a substantially reduced cost and resource level as compared to conventional techniques. The systems and methods disclosed may also be used to perform scenario analyses.

Abstract: An apparatus in an example comprises a manipulator, a force sensor, a signal modulator, and a visual indicator. The manipulator is employed by a user. The force sensor determines a force signal from a force applied by the manipulator on a part of an environment of the user. The signal modulator is adjustable by the user to select a switch point for the visual indicator based on relative fragility of the part of the environment. The signal modulator employs the force signal and the switch point to control the visual indicator for the user.

Abstract: Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line (represented by - - - - -) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR6, —NH—SO2R7; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl; n is 3, 4, 5, or 6; R4 and R5 independently from one another are hydrogen, halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, C1-6alkoxy-carbonyl, amino, azido, mercapto, C1-6alkylthio, polyhaloC1-6alkyl, aryl or Het; W is aryl or Het; R6 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R7 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl or naphthyl, each optio

Abstract: Compounds of the formula 1: including a stereoisomer thereof, or an N-oxide, a pharmaceutically acceptable addition salt, or a pharmaceutically acceptable addition solvate thereof; useful as HCV inhibitors; processes for preparing these compounds as well as pharmaceutical compositions comprising these compounds as active ingredient.

Abstract: Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR6, —NH—SO2R7; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl; n is 3, 4, 5, or 6; R4 and R5 taken together with the nitrogen atom to which they are attached form a bicyclic ring system selected from wherein said ring system may optionally be substituted with 1-3 substituents; R6 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R7 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl or naphthyl, each of which may be optionally substituted with 1-3 substituents; Het is a 5 or 6 membered satura

Abstract: Inhibitors of HCV replication of formula (I) and the N-oxides, salts, or stereoisomers thereof, wherein each dashed line (represented by - - - - -) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR6, —NH—SO2R7; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, or C3-7cycloalkyl; n is 3, 4, 5, or 6; R4 and R5 independently from one another are hydrogen, halo, hydroxy, nitro, cyano, carboxyl, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylcarbonyl, C1-6alkoxy-carbonyl, amino, azido, mercapto, C1-6alkylthio, polyhaloC1-6alkyl, aryl or Het; W is aryl or Het; R6 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R7 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl or naphthyl, each optio