Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36?, IL-36?, and/or IL-36?, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

Abstract: A metasurface may include a substrate layer and a two-dimensional array of metallic optical pillars arranged in rows and columns. A tunable dielectric material with a tunable refractive index is positioned between row-adjacent optical resonators. A two-dimensional active-matrix driver includes integrated driver routing layer(s), capacitor layer(s), and/or transistor layer(s). The driver routing layers enable row and column addressing of the two-dimensional array of metallic pillars via a row conductor for each row of metallic pillars and a column conductor for each column of metallic pillars. A transistor layer includes transistor devices connected to and configured to be selectively driven by the row and column conductors. The capacitor layer includes a plurality of storage capacitors. Each metallic pillar is connected in parallel to one of the storage capacitors in the capacitor layer and one of the transistor devices in the transistor layer.

Abstract: In various embodiments, a tunable optical surface includes a dielectric substrate layer with an array of elongated metal rails extending from the dielectric substrate parallel to one another and spaced from one another to form channels therebetween. The channels are etched deeper into the dielectric substrate to form extended-depth channels. The depth of each extended-depth channel is greater than the height of adjacent elongated metal rails. The dimensions of the elongated metal rails and the extended-depth channels therebetween may be subwavelength with respect to an operational bandwidth. A tunable dielectric material that has a tunable refractive index, such as liquid crystal, is positioned within the extended-depth channels between adjacent elongated metal rails.

Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36?, IL-36?, and/or IL-36?, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

Abstract: A mobile cleaning robot can include a body, a drive wheel, and a wheel stop. The drive wheel can be connected to the body and can be operable to move the mobile cleaning robot about an environment. The wheel stop can be movable with respect to the body and the drive wheel between a stop position and a release position. The wheel stop can be engageable with the drive wheel in the stop position to limit vertical travel of the drive wheel with respect to the body.

Abstract: Subwavelength conducting particles can be arranged on conducting surfaces to provide arbitrary thermal emissivity spectra. For example, a thermal emissivity spectrum can be tailored to suppress a thermal signature of an object without sacrificing radiative cooling efficiency.

Abstract: According to various embodiments, a tunable optical device comprises a tunable optical metasurface on a substrate with an integrated driver circuit. In some embodiments, the tunable optical device includes a photon shield layer to prevent optical radiation from disrupting operation of the driver circuit. In some embodiments, the tunable optical device includes a diagnostic circuit to detect and disable defective optical structures of the metasurface. In some embodiments, the tunable optical device includes an integrated heater circuit that maintains a liquid crystal of the metasurface above a minimum operating temperature. In some embodiments, the tunable optical device includes an integrated lidar sequencing controller, a steering pattern subcircuit, and a photodetector circuit.

Abstract: A mobile cleaning robot can include a body, a drive wheel, and a wheel stop. The drive wheel can be connected to the body and can be operable to move the mobile cleaning robot about an environment. The wheel stop can be movable with respect to the body and the drive wheel between a stop position and a release position. The wheel stop can be engageable with the drive wheel in the stop position to limit vertical travel of the drive wheel with respect to the body.

Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.

Abstract: A mobile cleaning robot can include a body, a drive wheel, and a wheel stop. The drive wheel can be connected to the body and can be operable to move the mobile cleaning robot about an environment. The wheel stop can be movable with respect to the body and the drive wheel between a stop position and a release position. The wheel stop can be engageable with the drive wheel in the stop position to limit vertical travel of the drive wheel with respect to the body.

Abstract: According to various embodiments, a tunable optical device comprises a tunable optical metasurface on a substrate with an integrated driver circuit. In some embodiments, the tunable optical device includes a photon shield layer to prevent optical radiation from disrupting operation of the driver circuit. In some embodiments, the tunable optical device includes a diagnostic circuit to detect and disable defective optical structures of the metasurface. In some embodiments, the tunable optical device includes an integrated heater circuit that maintains a liquid crystal of the metasurface above a minimum operating temperature. In some embodiments, the tunable optical device includes an integrated lidar sequencing controller, a steering pattern subcircuit, and a photodetector circuit.

Abstract: According to various embodiments, a tunable optical device comprises a tunable optical metasurface on a substrate with an integrated driver circuit. In some embodiments, the tunable optical device includes a photon shield layer to prevent optical radiation from disrupting operation of the driver circuit. In some embodiments, the tunable optical device includes a diagnostic circuit to detect and disable defective optical structures of the metasurface. In some embodiments, the tunable optical device includes an integrated heater circuit that maintains a liquid crystal of the metasurface above a minimum operating temperature. In some embodiments, the tunable optical device includes an integrated lidar sequencing controller, a steering pattern subcircuit, and a photodetector circuit.

Abstract: According to various embodiments, a cover is sealed over a metasurface on a substrate to create a sealed chamber. Liquid crystal, or another tunable refractive index dielectric material, is positioned within the sealed chamber around optical structures of the metasurface before or after the cover is sealed. For example, the liquid crystal may be injected through small vias or holes to fill a sealed chamber. In some embodiments, a glass cover is shaped or patterned with photoresist to protrude into the sealed chamber to reduce the thickness of the liquid crystal used to fill the sealed chamber. A driver to control the metasurface may be, for example, integrated within the substrate, be attached to exposed bond pads of the metasurface, and/or be embodied as a control layer connected to the metasurface through the substrate by through-substrate vias (TSVs).

Abstract: According to various embodiments, a tunable optical metasurface includes an array of elongated resonator rails arranged parallel to one another. Liquid crystal is positioned within an optical field region between adjacent resonator rails. A controller can selectively apply a voltage differential pattern to the elongated resonator rails to adjust a phase response thereof. According to various embodiments, a cross-backplane reflector is utilized that allows for mid-array routing or edge-array routing of electrical connections between the controller and the resonator rails. The cross-backplane reflector comprises a plurality of elongated optical reflectors extending parallel to one another and perpendicular to the array of resonator rails. An optically transmissive (e.g., transparent) dielectric may electrically separate the resonator rails from the optical reflectors. A pattern of vias formed therein facilitates electrical connections between the optical reflectors and the resonator rails.

Abstract: Subwavelength conducting particles can be arranged on conducting surfaces to provide arbitrary thermal emissivity spectra. For example, a thermal emissivity spectrum can be tailored to suppress a thermal signature of an object without sacrificing radiative cooling efficiency.

Abstract: A mobile cleaning robot can include a body, a pad assembly, and a pad drive system. The pad assembly can be connected to the body and can be movable relative thereto. The pad drive system can be connected to the body and can be operable to move the pad assembly relative to the body between a stored position and a cleaning position.

Abstract: Subwavelength conducting particles can be arranged on conducting surfaces to provide arbitrary thermal emissivity spectra. For example, a thermal emissivity spectrum can be tailored to suppress a thermal signature of an object without sacrificing radiative cooling efficiency.

Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD200R1 receptor protein (hu-CD200R1) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD200R1. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD200 binding to CD200R1.

Abstract: Machine learning systems and methods for multiscale Alzheimer's dementia recognition through spontaneous speech are provided. The system retrieves one or more audio samples and processes the one or more audio samples to extract acoustic features from audio samples. The system further processes the one or more audio samples to extract linguistic features from the audio samples. Machine learning is performed on the extracted acoustic and linguistic features, and the system indicates a likelihood of Alzheimer's disease based on output of machine learning performed on the extracted acoustic and linguistic features.

Abstract: The disclosure provides a method for fabricating a metallic optical metasurface having an array of hologram elements. The method includes forming a first copper layer protected with a conducting or dielectric barrier layer over a backplane structure by a damascene process. The first copper layer comprises a plurality of nano-gaps vertically extending from the backplane structure. The plurality of nano-gaps is filled with a dielectric material. The method also includes removing the dielectric material and a portion of the conducting or dielectric barrier layer to expose the portions in the nano-gaps of the first copper layer. The method may further include depositing a dielectric coating layer over the top portion and exposed side portions of the first copper layer to form a protected first copper layer, and filling the gaps with an electrically-tunable dielectric material that has an electrically-tunable refractive index.