Patents by Inventor Erik Miller

Erik Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230297896
    Abstract: A method for automatically assigning seats to a group of persons is provided. The method includes: receiving a first user input that relates to building space availability and a second user input that relates to employer requirements for seat occupancy; determining, based on the first and second user inputs, a building section within which seats are to be assigned to the group; and assigning, to each respective person within the group based on the first and second user inputs, a respective seat within the determined building section and a respective schedule during which the respective seat is to be occupied by the respective person. The assigning may be implemented by applying a machine learning algorithm that is trained by using historical data that relates prior seat occupancies of each respective person with the group.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 21, 2023
    Applicant: JPMorgan Chase Bank, N.A.
    Inventors: Luke STORRIE, Frank VAN HOOF, Zoe BERRY, Erik RITSEMA, Jonathan M. BAUM, Tom MARTIN, Kendall BERG, Rebecca CORNWELL, Rehaan DOUGLAS, Ella GASKIN, John MILLER
  • Patent number: 11629376
    Abstract: Methods, compositions, and systems are provided that allow for reliable sequencing of the initial sequence region of a sequence of interest. The methods of the invention allow for more reliable barcoding of subpopulations of nucleic acids to be sequenced.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: April 18, 2023
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Tyson A. Clark, Jonas Korlach, Cheryl Heiner, Kevin Travers, Erik Miller
  • Publication number: 20230087400
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Application
    Filed: June 1, 2022
    Publication date: March 23, 2023
    Inventors: Satwik Kamtekar, Erik Miller, Pranav Patel
  • Patent number: 11578364
    Abstract: The present disclosure provides methods, compositions, and systems for distributing polymerase compositions into array regions. In particular, the described methods, compositions, and systems utilize density differentials and/or additives to increase efficiency in the distribution of polymerase compositions to a surface as compared to methods utilizing only diffusion control.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: February 14, 2023
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Sassan Sheikholeslami, Michael W. Hunkapiller, Natasha Popovich, Lei Sun, Erik Miller, Satwik Kamtekar
  • Publication number: 20220364168
    Abstract: The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites. In particular, the methods, compositions, and systems of the present invention result in loading of polymerase enzyme complexes into a predetermined number of reaction sites, including nanoscale wells.
    Type: Application
    Filed: April 12, 2022
    Publication date: November 17, 2022
    Inventors: Jaime Juan Benitez-Marzan, Natasha Popovich, Lei Sun, Satwik Kamtekar, Keith Bjornson, Jeremiah Hanes, Karl Voss, Erik Miller, Thomas Linsky, Leewin Chern
  • Publication number: 20220235413
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include enhanced performance with large nucleotide analogs, increased stability, increased readlength, and improved detection of modified bases, and can also include resistance to photodamage, enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased accuracy, altered speed, increased cosolvent resistance, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Application
    Filed: November 10, 2021
    Publication date: July 28, 2022
    Inventors: Satwik Kamtekar, Erik Miller
  • Patent number: 11377644
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: July 5, 2022
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Satwik Kamtekar, Lei Jia, Erik Miller
  • Publication number: 20220170090
    Abstract: Sets of compounds bearing detectably different groups of labels are provided. Typically, different compounds bear different numbers of a single type of label and are thus distinguishable by the amplitude of signal produced by the label. The compounds are assembled from label components and protein cores to facilitate modular production of the compounds. In compounds containing two or more proteins, the proteins are typically covalently linked. Useful sets of compounds include sets of labeled nucleotide analogs, particularly dye-label nucleotide analogs that include tetravalent biotin-binding protein cores.
    Type: Application
    Filed: October 29, 2021
    Publication date: June 2, 2022
    Inventors: Erik Miller, Satwik Kamtekar
  • Patent number: 11198906
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification. Such properties include enhanced performance with large nucleotide analogs, increased stability, increased readlength, and improved detection of modified bases, and can also include resistance to photodamage, enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased accuracy, altered speed, increased cosolvent resistance, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: December 14, 2021
    Assignee: Pacific Biosciences of California, inc.
    Inventors: Satwik Kamtekar, Erik Miller
  • Publication number: 20210347808
    Abstract: Compositions, methods, and systems are provided for fluorescent polymerase enzyme substrates comprising protein shields for improving enzyme photostability in single molecule real time sequencing. Fluorescent polymerase enzyme substrates of the invention have a protein shield between the fluorescent dye moieties and nucleotide moieties of the polymerase enzyme substrate. The polymerase enzyme substrates have a nucleotide component and a dye component, each attached to a protein. The attachments can be covalent. The protein can, for example, prevent the direct interaction of the fluorescent dye moiety with the enzyme when carrying out nucleotide synthesis, preventing photodamage to the enzyme. The polymerase enzyme substrates of the invention can have multiple dyes and multiple nucleotide moieties.
    Type: Application
    Filed: April 14, 2021
    Publication date: November 11, 2021
    Inventors: Keith Bjornson, Jeremiah Hanes, Erik Miller, Satwik Kamtekar, Lubomir Sebo, Louis Brogley
  • Patent number: 11162138
    Abstract: Sets of compounds bearing detectably different groups of labels are provided. Typically, different compounds bear different numbers of a single type of label and are thus distinguishable by the amplitude of signal produced by the label. The compounds are assembled from label components and protein cores to facilitate modular production of the compounds. In compounds containing two or more proteins, the proteins are typically covalently linked. Useful sets of compounds include sets of labeled nucleotide analogs, particularly dye-label nucleotide analogs that include tetravalent biotin-binding protein cores.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: November 2, 2021
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Erik Miller, Satwik Kamtekar
  • Publication number: 20210299794
    Abstract: Systems and methods are disclosed for an enclosure providing a sealed environment. The enclosure employs movable paneling that seals an area for a laser welding cell, while allowing access for an operator to load a workpiece in and unload the workpiece from a welding cell. Barriers are arranged on the enclosure, such that in a closed configuration activation of a pneumatic tube forces the barriers to extend toward a rotated paneling, such that the edges of the enclosure contact or overlap with the edges of the paneling to result in a light-tight seal. Presence of the fluid increases the pressure in the tube such that an external boundary of the tube expands, forcing the barrier toward the edges of the paneling, thereby closing the gap and providing a light-tight enclosure.
    Type: Application
    Filed: March 23, 2021
    Publication date: September 30, 2021
    Inventors: Erik Miller, Brian Atkinson, Kevin Pagano
  • Patent number: 11103962
    Abstract: A method for controlling a start of a metalworking operation. The method includes detecting an initial contact between a wire being fed from a welding apparatus and a workpiece and, in response to the detection, halting feeding of the wire from the welding apparatus. The method further includes activating a high energy heat source configured to heat a tip of the wire and resuming the feeding of the wire from the welding apparatus when the tip of the wire is heated by the high energy heat source to a plastic state. The feeding of the wire is resumed by measuring a force feedback from the wire contacting the workpiece. An apparatus for implementing the method is also disclosed.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: August 31, 2021
    Assignee: ILLINOIS TOOL WORKS INC.
    Inventors: Dustin Wagner, William Giese, Rick Hutchison, Erik Miller, James Uecker
  • Publication number: 20210261928
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Application
    Filed: March 3, 2021
    Publication date: August 26, 2021
    Inventors: Satwik Kamtekar, Lei Jia, Robin Emig, Erik Miller, Walter H. Lee, Molly He, Insil Park
  • Publication number: 20210155908
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Application
    Filed: September 18, 2020
    Publication date: May 27, 2021
    Inventors: Satwik Kamtekar, Lei Jia, Erik Miller
  • Patent number: 11014958
    Abstract: Compositions, methods, and systems are provided for fluorescent polymerase enzyme substrates comprising protein shields for improving enzyme photostability in single molecule real time sequencing. Fluorescent polymerase enzyme substrates of the invention have a protein shield between the fluorescent dye moieties and nucleotide moieties of the polymerase enzyme substrate. The polymerase enzyme substrates have a nucleotide component and a dye component, each attached to a protein. The attachments can be covalent. The protein can, for example, prevent the direct interaction of the fluorescent dye moiety with the enzyme when carrying out nucleotide synthesis, preventing photodamage to the enzyme. The polymerase enzyme substrates of the invention can have multiple dyes and multiple nucleotide moieties.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: May 25, 2021
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Keith Bjornson, Jeremiah Hanes, Erik Miller, Satwik Kamtekar, Lubomir Sebo, Louis Brogley
  • Publication number: 20210121981
    Abstract: A welding or cladding apparatus in which one or more energy beam emitters are used to generate a wide beam spot transverse to a welding or cladding path, and one or more wide feeders feed wire to the spot to create a wide welding or cladding puddle.
    Type: Application
    Filed: October 13, 2020
    Publication date: April 29, 2021
    Inventors: William R. Giese, Erik Miller, Kirk Stema, Shuang Liu
  • Patent number: 10975362
    Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: April 13, 2021
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Satwik Kamtekar, Lei Jia, Robin Emig, Erik Miller, Walter H. Lee
  • Patent number: 10947493
    Abstract: Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: March 16, 2021
    Assignee: FloDesign Sonics, Inc.
    Inventors: Bart Lipkens, Rudolf Gilmanshin, Louis Masi, Benjamin Ross-Johnsrud, Erik Miller, Walter M. Presz, Jr., Thomas J. Kennedy, III
  • Publication number: 20210060711
    Abstract: The present disclosure relates to tubular welding electrodes that have a metallic sheath surrounding a granular core, wherein the metallic sheath comprises a metal matrix composite (MMC) that includes a ceramic material and aluminum or an aluminum alloy. The ceramic material may be in the form of microparticles or nanoparticles. The present disclosure also relates to method for making such tubular welding electrodes.
    Type: Application
    Filed: August 25, 2020
    Publication date: March 4, 2021
    Inventors: Erik Miller, Steven B. Massey, Shuang Liu, Joseph C. Bundy, Satya Kondapalli