Abstract: There is provided amino acid derivatives of formula I, 1

Abstract: There is provided compounds of formula I, 1

Abstract: There is provided compounds of formula I, 1

Abstract: There is provided amino acid derivatives of formula I, wherein p, q, R1, R2, R3, R4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I, 1

Abstract: There is provided compounds of formula I, wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I, R1O(O)C—CH2—(R)Cgl—Aze—Pab—R  I wherein R1 and R2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I, wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.

Abstract: Chip bin comprising, an upper container part, a discharge opening, and, arranged between the container part and the discharge opening, a discharge zone, preferably without moving parts, the discharge zone having a curvilinear roller shape in any freely chosen horizontal cross-section and the number of corners in the geometrical curvilinear figure of the cross-section is more than two, preferably three, in that the cross-section of the discharge zone decreases from the container part (5) down towards the discharge opening (4), and in at least one section of the discharge zone having a downwardly continuously decreasing curvilinear roller shaped cross-section.

Abstract: There is provided amino acid derivative formula I, ##STR1## wherein p, q, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract: There is provided compounds of formula I,R.sup.1 O(O)C--CH.sub.2 --(R)Cgl-Aze-Pab-R.sup.2 Iwherein R.sup.1 and R.sup.2 have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.

Abstract: The invention relates to a process for the production of enantiomerically-pure AzeOH which comprises selective crystallisation of a diastereomerically-pure tartrate salt thereof, followed by liberation of the free amino acid, as well as the compounds L-azetidine-2-carboxylic acid-D-tartrate and D-azetidine-2-carboxylic acid-L-tartrate.

Abstract: The present invention provides a method and apparatus for fuel handling in a nuclear reactor. The nuclear reactor has a reactor vessel comprising a reactor core with a plurality of fuel assemblies and control rods. A fuel pool is arranged adjacent to the reactor vessel. A group comprising at least a plurality of fuel assemblies is simultaneously lifted out of or into the reactor vessel with a single gripper, the gripper having a plurality of gripping devices. The group is transported between the reactor vessel and the fuel pool by means of the gripper.

Abstract: The present invention relates to a method and a device for correction of the movements of a suspension device and positioning thereof in a fluid. The suspension device is provided with a first and a second end, and the first end is suspended from a point (S). A correction device is arranged at the second end of the suspension device and adapted to generate a force which provides an acceleration in the fluid so that the position of the second end of the suspension device is corrected.

Abstract: The present invention is used in fuel handling for lifting of fuel assemblies and/or control rods out of/into a reactor vessel in a nuclear reactor. The reactor vessel comprises a reactor core with a plurality of fuel assemblies and control rods. A fuel pool is arranged adjacent the reactor vessel. A cassette comprising a plurality of storage positions for fuel assemblies and/or control rods is arranged near the reactor core, whereupon fuel assemblies and/or control rods are lifted out of the reactor core and arranged in the cassette. The cassette is then transported to the fuel pool for temporary storage.

Abstract: A process for the production of guanidino protected .omega.-aminoalkyl guanidines comprising reacting a diamine selectively at one amino group with an alkoxycarbonyl or aralkoxycarbonyl protected electrophilic guanylation reagent. The process of the invention is general and may be performed efficiently in one step yielding a product with high purity and in useful yields. The invention further refers to some compounds that are novel per se and to some novel compounds useful in the process of the invention.

Abstract: A process for the production of a 5-7 membered ring cyclic sulfonium salt compound, including a 5-7 membered ring cyclic sulfonium salt compound having a non-nucleophilic anion, is described. Members of the latter group are potentially useful as initiators for cationic polymerizations. The process comprises reacting a 1.4-, 1.5-, or 1.6-diol compound or a 5-7 membered ring cyclic ether compound with a mercapto compound and a strong protonic acid yielding the cyclic sulfonium salt compound. Some compounds described are also novel compounds per se.

Abstract: A process for the production of guanidino protected .omega.-aminoalkyl guanidines comprising reacting a diamine selectively at one amino group with an alkoxycarbonyl or aralkoxycarbonyl protected electrophilic guanylation reagent. The process of the invention is general and may be performed efficiently in one step yielding a product with high purity and in useful yields. The invention further refers to some compounds that are novel per se and to some novel compounds useful in the process of the invention.

Abstract: Initiators for cationic polymerization by thermal activation, photochemical activation (UV-irradiation) or activation by electron bombardment are compounds wherein a heterocyclic, aryl substituted or aryl ring is fused to a sulfonium moiety in combination with a non-nucleophilic anion. During the activation of the initiator, a carbon-sulfur bond is broken leading to formation of a sulfide and a carbonium ion within the same molecule. The carbonium ion initiates the polymerization.