Abstract: A method of organizing ideas in a computer database (FIG. 1) includes the steps of: (a) maintaining a computer database (22) for accumulating ideas (34), including positive comments and negative comments; (b) systematically directing a contributor (27a) of a comment, which is in response to a displayed negative comment, to contribute a positive comment for entry into said database by using a given computer-displayed form element adapted for receiving said contribution; and (c) providing a bi-directional access link between the display of the negative comment and a display of the contributed positive comment. A complementary method is used a negative comment is contributed in to a displayed positive comment. The positive comments include solution ideas and the negative comments include problem ideas.

Abstract: A process which allows for the preparation of a substantially uniform hydrogel, such as a polyacrylamide hydrogel, wherein the uniformity of the hydrogel, in terms of the rheological properties, is established by limiting the temperature differential in the reaction process to a very narrow range, such as no more than 5° C. This process allows for polymers novel in their uniformity also by means of being suitably a continuous process. A continuous process for the preparation of a substantially uniform hydrogel, such as a polyacrylamide hydrogel, led to high uniformity by preventing unreacted monomers, such as acrylamide, from surpassing the gel front in the pipe reactor. This was achieved by use of a static mixer. Polymer hydrogels are rendered biocompatible by means of a novel washing process wherein the polymer specific surface area is appropriately set.

Abstract: Various methods of managing ideas include different combinations of following steps: (a) maintaining a computer database for accumulating ideas for prospectively patentable inventions.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be identified in different ways. In accordance with the present invention, a method is provided for generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets. By appending specific functionalities and/or groups to one or more binding moieties, the reactive functionalities gain binding affinity and specificity for particular proteins and classes of proteins. Such libraries of candidate compounds, referred to herein as activity-based probes, or ABPs, are used to screen for one or more desired biological activities or target proteins.

Abstract: A transmitter for transmitting at least two main signal components (L,R) includes a first data compression circuit (BRR1) for performing a data compression of a first of the main signal components, a data expansion circuit (DEQ) for performing a data expansion of the compressed signal component so as to obtain a replica of the first main signal component, and a matrixing circuit for combining the second main signal component with the replica of the first main signal component so as to obtain a combined signal (M'). A second data compression circuit (BRR2) performs a data compression of the combined signal (M') in response to a masking control signal. The output signals of the first and second data compression circuits are combined as a composite signal for transmission via a transmission medium, for example a record carrier. The invention also provide a receiver for such a transmitted composite signal. The transmitter may be adapted to provide for transmission of three individual signal components (L,R,C).

Abstract: Open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.

Abstract: Macrocyclic enediynediols and enediynediones having a ten carbon ring and open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.