Patents by Inventor Ernest G. Schutt
Ernest G. Schutt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020065467Abstract: Methods, systems and devices are provided for monitoring and quantifying the movement of fluid in a target region. Generally, an imaging agent is introduced into a target region through fluid flow. The imaging agent in the target region is then disrupted using appropriate methods such as the application of ultrasonic energy. As fluid flow brings undisrupted imaging agent into the target region, the rate of accumulation is monitored and quantified thereby providing the exchange rate and flow rate of the fluid in the target region. The disclosed invention is particularly useful for medical applications such as determining the flow rate of blood in an organ or tissue.Type: ApplicationFiled: September 27, 2001Publication date: May 30, 2002Inventor: Ernest G. Schutt
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Publication number: 20020054854Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760−x) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.Type: ApplicationFiled: November 16, 2001Publication date: May 9, 2002Inventors: Ernest G. Schutt, David P. Evitts, Rene Alta Kinner, Charles David Anderson, Jeffry G. Weers
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Publication number: 20020051750Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760−x) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.Type: ApplicationFiled: May 21, 2001Publication date: May 2, 2002Applicant: Alliance Pharmaceutical Corp.Inventors: Ernest G. Schutt, David P. Evitts, Rene Alta Kinner, Charles David Anderson, Jeffry G. Weers
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Patent number: 6372195Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760−x) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.Type: GrantFiled: January 17, 1997Date of Patent: April 16, 2002Assignee: Alliance Pharmaceutical Corp.Inventors: Ernest G. Schutt, David P. Evitts, Rene Alta Kinner, Charles David Anderson, Jeffry G. Weers
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Publication number: 20020037316Abstract: Phospholipid based powders for drug delivery applications are disclosed. The powders comprise a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.Type: ApplicationFiled: May 8, 2001Publication date: March 28, 2002Inventors: Jeffry G. Weers, Thomas E. Tarara, Luis A. Dellamary, Jean G. Riess, Ernest G. Schutt
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Publication number: 20020028179Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ration of from about 1:100 to abut 1000:1, and wherein the first gas has a vapor pressure of at least about (760—X) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.Type: ApplicationFiled: July 30, 2001Publication date: March 7, 2002Inventors: Ernest G. Schutt, Charles David Anderson, David P. Evitts
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Publication number: 20010046474Abstract: Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.Type: ApplicationFiled: May 21, 2001Publication date: November 29, 2001Inventors: Jeffry G. Weers, Ernest G. Schutt, Luis A. Dellamary, Thomas E. Tarara, Alexey Kabalnov
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Patent number: 6309623Abstract: Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.Type: GrantFiled: December 22, 1998Date of Patent: October 30, 2001Assignee: Inhale Therapeutic Systems, Inc.Inventors: Jeffry G. Weers, Ernest G. Schutt, Luis A. Dellamary, Thomas E. Tarara, Alexey Kabalnov
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Patent number: 6287539Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760−x) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.Type: GrantFiled: May 5, 1997Date of Patent: September 11, 2001Assignee: Alliance Pharmaceuticals Corp.Inventors: Ernest G. Schutt, Charles David Anderson, David P. Evitts
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Patent number: 6280704Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ration of from about 1:100 to abut 1000:1, and wherein the first gas has a vapor pressure of at least about (760−X) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.Type: GrantFiled: December 8, 1997Date of Patent: August 28, 2001Assignee: Alliance Pharmaceutical Corp.Inventors: Ernest G. Schutt, Charles David Anderson, David P. Evitts
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Patent number: 6258339Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760−x) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.Type: GrantFiled: May 5, 1997Date of Patent: July 10, 2001Assignee: Alliance Pharmaceutical Corp.Inventors: Ernest G. Schutt, David P. Evitts, Rene Alta Kinner, Charles David Anderson, Jeffry G. Weers
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Patent number: 6193952Abstract: A gas emulsion for ultrasound contrast enhancement comprising a plurality of gas bubbles in a liquid medium, the gas bubbles comprising at least one fluoroether selected from the group consisting of CF3OCF2OCF3, CF3(OCF2)2OCF3, CF3(OCF2)3OCF3, and CF3(OCF2)4OCF3.Type: GrantFiled: February 9, 1998Date of Patent: February 27, 2001Assignee: Alliance Pharmaceutical Corp.Inventors: Alexey Kabalnov, Ernest G. Schutt, Jeffry G. Weers
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Patent number: 6116235Abstract: Methods and apparatus for the conservation of respiratory promoters following their pulmonary introduction are disclosed. In preferred embodiments the present invention provides methods and apparatus for reducing the loss of respiratory promoter, and particularly fluorochemcials, during medical procedures such as liquid ventilation. The disclosed methods comprise the use of vapor retention assemblies, which may be conventional heat and moisture exchangers, to passively retain the respiratory promoter and return it to the lungs in subsequent breaths. Novel vapor retention assemblies comprising fluorophilic exchange elements are also disclosed.Type: GrantFiled: June 27, 1997Date of Patent: September 12, 2000Assignee: Alliance Pharmaceutical Corp.Inventors: Mark A. Walters, Ernest G. Schutt, John K. Hoffman, Mark H. Wyzgala, W. Dean Kirkland
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Patent number: 6056943Abstract: A method for ultrasonic harmonic imaging is disclosed, which uses microbubbles particularly selected for their properties of reradiating ultrasound energy at frequencies other than the exciting frequency.Type: GrantFiled: June 5, 1998Date of Patent: May 2, 2000Assignee: Alliance Pharmaceutical Corp.Inventor: Ernest G. Schutt
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Patent number: 6041777Abstract: Methods and apparatus are provided which allow for closed-circuit ventilation for the treatment or diagnosis of disorders. The closed-circuit ventilation apparatus of the present invention provide a closed-circuit respirator that isolates the gas flow path from the ventilator apparatus. This allows the prolonged administration of expensive materials such as fluorochemicals without excessive loss due to evaporation. As such the provided methods an apparatus are particularly applicable to liquid ventilation including partial liquid ventilation and total liquid ventilation.Type: GrantFiled: December 1, 1995Date of Patent: March 28, 2000Assignee: Alliance Pharmaceutical Corp.Inventors: Nicholas Simon Faithfull, Ernest G. Schutt
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Patent number: 6036644Abstract: A method for ultrasonic harmonic imaging is disclosed, which uses microbubbles particularly selected for their properties of reradiating ultrasound energy at frequencies other than the exciting frequency.Type: GrantFiled: June 5, 1998Date of Patent: March 14, 2000Assignee: Alliance Pharmaceutical Corp.Inventor: Ernest G. Schutt
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Patent number: 6019960Abstract: A method for ultrasonic harmonic imaging is disclosed, which uses microbubbles particularly selected for their properties of reradiating ultrasound energy at frequencies other than the exciting frequency.Type: GrantFiled: June 27, 1997Date of Patent: February 1, 2000Assignee: Alliance Pharmaceutical Corp.Inventor: Ernest G. Schutt
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Patent number: 5829428Abstract: Methods and apparatus for the conservation of respiratory promoters following their pulmonary introduction are disclosed. In preferred embodiments the present invention provides methods and apparatus for reducing the loss of respiratory promoter, and particularly fluorochemcials, during medical procedures such as liquid ventilation. The disclosed methods comprise the use of vapor retention assemblies, which may be conventional heat and moisture exchangers, to passively retain the respiratory promoter and return it to the lungs in subsequent breaths. Novel vapor retention assemblies comprising fluorophilic exchange elements are also disclosed.Type: GrantFiled: May 29, 1996Date of Patent: November 3, 1998Assignee: Alliance Pharmaceutical Corp.Inventors: Mark A. Walters, Ernest G. Schutt, John K. Hoffman, Mark H. Wyzgala, W. Dean Kirkland
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Patent number: 5733527Abstract: A method for ultrasonic harmonic imaging is disclosed, which uses microbubbles particularly selected for their properties of reradiating ultrasound energy at frequencies other than the exciting frequency.Type: GrantFiled: July 29, 1996Date of Patent: March 31, 1998Assignee: Alliance Pharmaceutical Corp.Inventor: Ernest G. Schutt
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Patent number: 5720938Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.Type: GrantFiled: June 7, 1995Date of Patent: February 24, 1998Assignee: Alliance Pharmaceutical Corp.Inventors: Ernest G. Schutt, Charles David Anderson, David P. Evitts