Patents by Inventor Ernest S. Kim
Ernest S. Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11298267Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.Type: GrantFiled: February 11, 2019Date of Patent: April 12, 2022Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
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Patent number: 10596267Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.Type: GrantFiled: June 23, 2017Date of Patent: March 24, 2020Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Eye and Ear Infirmary, Massachusetts Institute of TechnologyInventors: Jeffrey T. Borenstein, Erin Pararas, Ernest S. Kim, Vishal Tandon, Andrew Ayoob, Michael McKenna, William Sewell, Marcello Peppi, Marc Weinberg, Robert Langer
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Publication number: 20190167480Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.Type: ApplicationFiled: February 11, 2019Publication date: June 6, 2019Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
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Patent number: 10232336Abstract: The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.Type: GrantFiled: November 6, 2014Date of Patent: March 19, 2019Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc.Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, Jr., Mitchell Hansberry, Stephen Bellio
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Patent number: 10207227Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.Type: GrantFiled: May 22, 2017Date of Patent: February 19, 2019Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford
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Patent number: 10201455Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.Type: GrantFiled: June 21, 2017Date of Patent: February 12, 2019Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
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Publication number: 20180000956Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.Type: ApplicationFiled: June 23, 2017Publication date: January 4, 2018Inventors: Jeffrey T. Borenstein, Erin Pararas, Ernest S. Kim, Vishal Tandon, Andrew Ayoob, Michael McKenna, William Sewell, Marcello Peppi, Marc Weinberg, Robert Langer
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Publication number: 20170367892Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.Type: ApplicationFiled: June 21, 2017Publication date: December 28, 2017Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
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Patent number: 9764121Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.Type: GrantFiled: November 3, 2014Date of Patent: September 19, 2017Assignees: THE CHARLES STARK DRAPER LABORATORY, INC., MASSACHUSETTS EYE AND EAR INFIRMARYInventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
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Publication number: 20170252702Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.Type: ApplicationFiled: May 22, 2017Publication date: September 7, 2017Inventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford
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Patent number: 9656212Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.Type: GrantFiled: January 8, 2013Date of Patent: May 23, 2017Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford
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Publication number: 20170058440Abstract: Wires, such as microwires or nanowires are braided, woven or twisted by attaching an end piece to a first end of a plurality of wires, wherein the end piece has a response to an electromagnetic or fluidic work force different than that of the wire. The end pieces are manipulated relative to each other by selective application of electromagnetic or fluidic force that braids, weaves or twist the wires at the first end, while the second ends of each of the wires remain fixed relative to each other.Type: ApplicationFiled: August 26, 2016Publication date: March 2, 2017Inventors: Amy Duwel, John LeBlanc, David J. Carter, Ernest S. Kim
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Publication number: 20160244727Abstract: Artificial microvascular devices may include a polymer scaffold that defines a channel with a distensible wall.Type: ApplicationFiled: May 3, 2016Publication date: August 25, 2016Inventors: Jeffrey T. Borenstein, James Ching-Ming Hsiao, Mark E. Keegan, Ernest S. Kim
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Patent number: 9180239Abstract: A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices.Type: GrantFiled: December 5, 2012Date of Patent: November 10, 2015Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Jeffrey T. Borenstein, Joseph L. Charest, James C. Hsiao, Tatiana Kniazeva, Ernest S. Kim, Alla Epshteyn, Vijaya Kolachalama
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Publication number: 20150157837Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.Type: ApplicationFiled: November 3, 2014Publication date: June 11, 2015Inventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
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Publication number: 20150126411Abstract: The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.Type: ApplicationFiled: November 6, 2014Publication date: May 7, 2015Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, JR., Mitchell Hansberry, Stephen Bellio
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Patent number: 9006149Abstract: A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.Type: GrantFiled: January 14, 2010Date of Patent: April 14, 2015Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc.Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, Jr.
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Patent number: 8876795Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.Type: GrantFiled: February 2, 2012Date of Patent: November 4, 2014Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Eye and Ear InfirmaryInventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
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Publication number: 20140190884Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.Type: ApplicationFiled: January 8, 2013Publication date: July 10, 2014Applicant: The Charles Stark Draper LaboratoryInventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford
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Publication number: 20130053823Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.Type: ApplicationFiled: February 2, 2012Publication date: February 28, 2013Inventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim