Patents by Inventor Ernest S. Kim

Ernest S. Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11395524
    Abstract: An article of footwear and a method of manufacturing an article of footwear includes a strobel having a forefoot region, a midfoot region, and a heel region. The strobel may define a forefoot through hole in the forefoot region and a heel through hole in the heel region. The shape, the position, or both the shape and the position of the forefoot through hole and the heel through hole may be based on a foot pressure map. A method of manufacturing an article of footwear comprises securing a midsole to a strobel, wherein the strobel has a forefoot region, a midfoot region, and a heel region, the strobel defines a forefoot through hole in the forefoot region and a heel through hole in the heel region, and the shape and/or position of the forefoot through hole and the heel through hole are based on a foot pressure map.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: July 26, 2022
    Assignee: NIKE, Inc.
    Inventors: Ernest E. Kim, Fabricio da Costa Pereira Machado, Jeffrey S. To
  • Patent number: 11298267
    Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: April 12, 2022
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
  • Patent number: 10596267
    Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: March 24, 2020
    Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Eye and Ear Infirmary, Massachusetts Institute of Technology
    Inventors: Jeffrey T. Borenstein, Erin Pararas, Ernest S. Kim, Vishal Tandon, Andrew Ayoob, Michael McKenna, William Sewell, Marcello Peppi, Marc Weinberg, Robert Langer
  • Publication number: 20190167480
    Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.
    Type: Application
    Filed: February 11, 2019
    Publication date: June 6, 2019
    Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
  • Patent number: 10232336
    Abstract: The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: March 19, 2019
    Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, Jr., Mitchell Hansberry, Stephen Bellio
  • Patent number: 10207227
    Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: February 19, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford
  • Patent number: 10201455
    Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: February 12, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
  • Publication number: 20180000956
    Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.
    Type: Application
    Filed: June 23, 2017
    Publication date: January 4, 2018
    Inventors: Jeffrey T. Borenstein, Erin Pararas, Ernest S. Kim, Vishal Tandon, Andrew Ayoob, Michael McKenna, William Sewell, Marcello Peppi, Marc Weinberg, Robert Langer
  • Publication number: 20170367892
    Abstract: The present disclosure discussed a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. Because the therapeutic substance is delivery directly to the inner ear the delivery of the therapeutic substance is not subject to limitations on molecule size and inconsistent diffusion rates that are present when therapeutic substances are diffused across the round window membrane.
    Type: Application
    Filed: June 21, 2017
    Publication date: December 28, 2017
    Inventors: Ernest S. Kim, Michael McKenna, Ruwan Kiringoda
  • Patent number: 9764121
    Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: September 19, 2017
    Assignees: THE CHARLES STARK DRAPER LABORATORY, INC., MASSACHUSETTS EYE AND EAR INFIRMARY
    Inventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
  • Publication number: 20170252702
    Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
    Type: Application
    Filed: May 22, 2017
    Publication date: September 7, 2017
    Inventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford
  • Patent number: 9656212
    Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: May 23, 2017
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford
  • Publication number: 20170058440
    Abstract: Wires, such as microwires or nanowires are braided, woven or twisted by attaching an end piece to a first end of a plurality of wires, wherein the end piece has a response to an electromagnetic or fluidic work force different than that of the wire. The end pieces are manipulated relative to each other by selective application of electromagnetic or fluidic force that braids, weaves or twist the wires at the first end, while the second ends of each of the wires remain fixed relative to each other.
    Type: Application
    Filed: August 26, 2016
    Publication date: March 2, 2017
    Inventors: Amy Duwel, John LeBlanc, David J. Carter, Ernest S. Kim
  • Publication number: 20160244727
    Abstract: Artificial microvascular devices may include a polymer scaffold that defines a channel with a distensible wall.
    Type: Application
    Filed: May 3, 2016
    Publication date: August 25, 2016
    Inventors: Jeffrey T. Borenstein, James Ching-Ming Hsiao, Mark E. Keegan, Ernest S. Kim
  • Patent number: 9180239
    Abstract: A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: November 10, 2015
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jeffrey T. Borenstein, Joseph L. Charest, James C. Hsiao, Tatiana Kniazeva, Ernest S. Kim, Alla Epshteyn, Vijaya Kolachalama
  • Publication number: 20150157837
    Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
    Type: Application
    Filed: November 3, 2014
    Publication date: June 11, 2015
    Inventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
  • Publication number: 20150126411
    Abstract: The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, JR., Mitchell Hansberry, Stephen Bellio
  • Patent number: 9006149
    Abstract: A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: April 14, 2015
    Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, Jr.
  • Patent number: 8876795
    Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: November 4, 2014
    Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Jason O. Fiering, Mark J. Mescher, Erin E. Pararas, Jeffrey T. Borenstein, William F. Sewell, Sharon G. Kujawa, Michael J. McKenna, Ernest S. Kim
  • Publication number: 20140190884
    Abstract: An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
    Type: Application
    Filed: January 8, 2013
    Publication date: July 10, 2014
    Applicant: The Charles Stark Draper Laboratory
    Inventors: Christopher DiBiasio, Joseph L. Charest, Jeffrey T. Borenstein, Ernest S. Kim, Daniel I. Harjes, Kevin Hufford