Abstract: Compositions are described which are useful in preserving any topically applied solution. Compositions including urea-hydrogen peroxide complex in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions. A hydrogen peroxide component of such solutions, when introduced into the eye, is converted to oxygen and water, leaving only the natural product, urea.

Abstract: The use of compositions containing one or more ether amine antimicrobial agents and/or ether amine derivative antimicrobial agents in an amount effective to disinfect and/or preserve medical devices is described. Solutions containing one or more ether amine antimicrobial agent- and/or ether amine derivative antimicrobial agent-containing compositions and methods of making and using the same are also described.

Abstract: The use of one or more compositions of one or more disinfecting agents at a relatively high pH to disinfect contact lenses and preserve ophthalmic lens compositions is described. Ophthalmic lens solutions containing one or more compositions of one or more disinfecting agents at a relatively high pH and methods of making and using the same are also described.

Abstract: The use of compositions containing one or more oligosaccharides in an amount effective to disinfect and/or preserve medical devices, pharmaceutical preparations, and the like is described. Buffered solutions containing one or more oligosaccharide-containing compositions and methods of making and using the same are also described.

Abstract: The present invention is a composition comprising a preservative-effective amount of a zinc compound and less than a preservative-effective amount of a primary preservative agent—preferably no primary preservative agent. In one aspect of the present invention, there is a method of enhancing an ophthalmic composition, process for making a composition and a method of treating a patient using one or more compositions according to the present invention.

Abstract: Compositions are described which are useful in preventing the loss of tight epithelial cell junctions upon topical application. Such compositions include one or more carbohydrates in an amount effective to prevent the loss of tight cell junctions and hence improve the management of tissue health.

Abstract: Methods for enhancing biocidal efficacies and product stability of lens care solutions comprising packaging such solutions in containers fabricated from poly(ethylene terephalate).

Abstract: Compositions are described which are useful in preserving any topically applied solution. Compositions including one or more cationic polysaccharides in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions.

Abstract: The use of a composition of one or more cationic polysaccharides in combination with one or more antimicrobial agents to disinfect contact lenses and preserve ophthalmic lens compositions is described. Ophthalmic lens solutions containing compositions of one or more cationic polysaccharides in combination with one or more antimicrobial agents and methods of making and using the same are also described.

Abstract: Compositions are described which are useful in preserving any topically applied solution. Compositions including one or more saccharides in combination with one or more cationic polysaccharides in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions.

Abstract: Compositions and methods for cleaning contact lenses employing one or more nonionic polyether surfactants having a HLB of less than 12 in an amount effective to reduce the amount of lipids on the contact lenses, thus rendering the contact lenses easier to clean. Additionally, by soaking contact lenses in the composition prior to inserting the lens on the eye, the compositions provide a prophylactic effect in preventing lipid deposition while the contact lens is worn.

Abstract: Contact lens cleaning compositions comprising preserved surfactant-containing solutions of a poly(oxypropylene)-poly(oxyethylene) adduct of ethylene diamine having a molecular weight from about 7500 to as high as 27,000 wherein at least 40 weight percent of the adduct is poly(oxyethylene) hydrophilic units. The solutions are effective in removing protein/lipid tear film deposits on both hard and soft contact lenses while providing a prophylactic-like action in retarding the formation of subsequent tear film deposits. The compositions provide effective cleaning and conditioning action using both ambient and high temperature disinfection methods.

Abstract: A method of manufacturing an ophthalmic lens, involves contacting the lens with an aqueous solution comprising a surfactant to remove debris from the lens, prior to inspecting and packaging the lens. The aqueous solution may further comprise a buffering agent and/or sodium chloride. Preferred surfactants include polyoxyethylene-polyoxypropylene block copolymer, nonionic surfactants, such as a poloxamer or a poloxamine. The methods may also be employed for additional biomedical devices, such as ophthalmic implants.

Abstract: The present invention is directed to an ophthalmic solution for soft contact lenses for controlled release of polyethers into an eye's tear film. Polyether components of the subject ophthalmic solution are released from the soft contact lens material matrix over long time periods to produce longer lasting wetting performance, improved lubricity, improved end-of-the-day comfort and reduced feeling of dryness from wearing contact lenses.

Abstract: Ophthalmic compositions include a polycation material to enhance antimicrobial efficacy against bacteria such as E. coli. The compositions include eye drop and contact lens treating solutions. A preferred polycation material is cationic cellulose derivatives.

Abstract: Ophthalmic compositions such as eye drop and contact lens treating solutions include a polycationic material to enhance antimicrobial efficacy against protozoans such as acanthamoebae. One preferred class of polycationic materials is cationic cellulose derivatives.

Abstract: The invention provides an ophthalmic aqueous composition for topical administration, comprising: (a) a block copolymer of propylene oxide and ethylene oxide in concentration sufficient to provide viscosity of less than about 25 centipoise at ambient temperature and viscosity of from about 25 to about 55 centipoise when applied topically to a patient; (b) hydroxypropyl methylcellulose in concentration sufficient to improve the durability of the gel formed by the block copolymer. The invention further provides a method for administering ophthalmic pharmaceuticals.

Abstract: The invention provides a method for inhibiting the binding of a biguanide antimicrobial in aqueous solution to a hydrogel in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit sorption of the biguanide antimicrobial to a hydrogel.

Abstract: The invention provides a method for inhibiting the binding of a biguanide antimicrobial in aqueous solution to a hydrogel in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit sorption of the biguanide antimicrobial to a hydrogel.

Abstract: The invention provides a method for inhibiting the binding of a biguanide disinfectant in aqueous solution to a poly(ethylene) solid in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit binding of the biguanide disinfectant to the poly(ethylene) solid.