Patents by Inventor Eswaraiah Sajja

Eswaraiah Sajja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240327352
    Abstract: The present invention provides a novel process for the preparation of 1-(2-{4-[(4-carbamoyl piperidin-1-yl)methyl]-N-methylbenzamido}ethyl) piperidin-4-yl N-({1, 1?-biphenyl}-2-yl) carbamate of formula (I).
    Type: Application
    Filed: July 16, 2022
    Publication date: October 3, 2024
    Applicant: MSN LABORATORIES PRIVATE LTD, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Rajeshwar Reddy SAGYAM, Navin Kumar Reddy KESHAVAREDDY, Krishna KOOTIKANTI
  • Publication number: 20240300930
    Abstract: The present invention relates to a novel process for the preparation of 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine-1-oxide of formula (I) The present invention also relates to the novel intermediate compounds of formula (V), formula (VII), and their processes for the preparation thereof. The present invention also relates to the use of compounds of formula (V), formula (VII) intermediate in the preparation of 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1, 2, 4-oxadiazol-3-yl)-4, 6-dimethylpyridine-1-oxide of formula (I).
    Type: Application
    Filed: February 28, 2022
    Publication date: September 12, 2024
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Rajeshwar Reddy SAGYAM, Navin Kumar Reddy KESHAVAREDDY, Ananthan BAKTHAVACHALAM
  • Publication number: 20240279266
    Abstract: The present invention relates to an improved process for the preparation of (4R)-1-[(2R, 4R, 5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one compound of formula-1 and its intermediate compounds. [Formula should be inserted here]. The present invention also relates to the process for the purification of (4R)-1-[(2R, 4R, 5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one compound of formula-1 to get pure compound of formula-1.
    Type: Application
    Filed: May 30, 2022
    Publication date: August 22, 2024
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Srinivas Reddy GADE, Suresh CHALLA, Shiva Shankar Goud GOPULARAM
  • Publication number: 20240199615
    Abstract: The present invention relates to novel crystalline polymorphs of 1-[(3R)-3-[4-amino-3(4-phenoxy phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one represented by the following structural formula-1 and process for preparation thereof.
    Type: Application
    Filed: February 19, 2020
    Publication date: June 20, 2024
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Vijayavitthal T MATHAD, Rajeshwar Reddy SAGYAM, Srinivasulu RANGINENI, Venkata Narasayya SALADI
  • Publication number: 20240018152
    Abstract: The present invention relates to a novel process for the preparation of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4, 5, 6, 7-tetrahydropyrazolo[1,5-a] pyrimidine-3-carboxamide of formula-1 or its salts. The present invention also relates to novel process for the preparation of intermediate compound of Formula-7 and recovery of the intermediate compound of Formula-12, which is used in the preparation of compound of Formula-7. The compounds of formula-1 & formula-7 are represented by following structural formulae.
    Type: Application
    Filed: November 15, 2022
    Publication date: January 18, 2024
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Satyanarayana REVU, Srinivas Reddy GADE, Malla Reddy ADLA, Naveen RAGAM
  • Publication number: 20230233547
    Abstract: The present invention relates to a pharmaceutical composition comprising N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N?-(4-fluoro phenyl) cyclopropane-1,1-dicarboxamide, (2S)-hydroxy butanedioate of formula-1 and a pharmaceutically acceptable carrier wherein the said pharmaceutical composition has a dimer impurity of formula-2 less than about 2.0% as measured by HPLC.
    Type: Application
    Filed: April 15, 2021
    Publication date: July 27, 2023
    Applicant: MSN Laboratories Private Limited, R & D Center
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Nagaraju CH V S, Ramachandra Reddy POREDDY, Srinivasulu POLYSETTY, Raghava Raju Sudhakar VALIVARTHI
  • Publication number: 20230072265
    Abstract: The present invention relates to an improved process for the preparation of 4-({(1R)-2-[5-(2-fluoro-3-methoxy phenyl)-3-{[2-fluoro-6-(trifluoro methyl) phenyl] methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts.
    Type: Application
    Filed: December 24, 2020
    Publication date: March 9, 2023
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkat Reddy GHOJALA, Venkataiah MALLAM
  • Publication number: 20220315605
    Abstract: The present invention provides pure (1?R,6R,6aR,7R,13S,14S,16R)-5-(acetyloxy)-3?,4?,6,6a,7,13,14,16-octahydro-6?,8,14-trihydroxy-7?,9-dimethoxy-4,10,23-trimethyl spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7, 8]isoquino[3,2-b][3] benzazocine-20,1?(211)-isoquinolin]-19-one of formula (1) substantially free from one or more impurities selected from intermediate compound of formula (50), cyclic impurity of formula (A), deshydroxy impurity of formula (B) and hydroxy impurity of formula (C).
    Type: Application
    Filed: June 29, 2020
    Publication date: October 6, 2022
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Rajeshwar Reddy SAGYAM, Navin Kumar Reddy KESHAVAREDDY
  • Patent number: 11434256
    Abstract: The present invention relates to an improved process for the preparation of 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid which are useful in the preparation of pure 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: September 6, 2022
    Assignee: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkata Panakala Rao Gogulapati, Ganapathi Chary Nagunuri
  • Publication number: 20220251052
    Abstract: The present invention relates to process for the preparation of 2-(3,5-dichlorophenyl)-1,3- benzoxazole-6-carboxylic acid of formula (I), its pharmaceutically acceptable salts and polymorphs thereof which are used in the treatment of cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis.
    Type: Application
    Filed: July 4, 2020
    Publication date: August 11, 2022
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkat Reddy GHOJALA, Rajeshwar Reddy SAGYAM, Markandeya BEKKAM
  • Publication number: 20220204514
    Abstract: The present invention relates to novel crystalline forms of butanedioic acid 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide of formula-la and process for preparation thereof. The present invention also relates to a process for the preparation of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide. Further, the present application also relates to acid addition salts of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide and process for the preparation thereof.
    Type: Application
    Filed: April 29, 2020
    Publication date: June 30, 2022
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Satyanarayana REVU, Rajeshwar Reddy SAGYAM, Srinivasulu RANGINENI, Ravichandran SRINIVASAN, Venkata Narasayya SALADI, Naveen RAGAM
  • Publication number: 20220112212
    Abstract: The present invention relates to novel crystalline polymorphs of sodium (4R,12aS)-9-{[(2,4-difluorophenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b] [1,3] oxazin-7-olate represented by the following structural formula-1a and process for their preparation. The present invention further relates to novel solvated forms of sodium (4R,12aS)-9-{[(2,4-difluoro phenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b][1,3] oxazin-7-olate compound of formula-1a and process for their preparation.
    Type: Application
    Filed: February 4, 2020
    Publication date: April 14, 2022
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Rajeshwar Reddy SAGYAM, Srinivasulu RAGINENI, Venkata Narasayya SALADI
  • Patent number: 11279696
    Abstract: The Present Invention relates to process for the preparation of 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one represented by the following structural formula-1.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: March 22, 2022
    Assignee: MSN LABORATORIES PRIVATE LIMITED
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkat Reddy Ghojala, Rajashekar Kommera
  • Patent number: 11261160
    Abstract: The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: March 1, 2022
    Assignee: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkata Panakala Rao Gogulapati, Rajeshwar Reddy Sagyam, Shyam Kiran Babu Gandham, Rajesham Boge
  • Patent number: 11236050
    Abstract: The present invention relates to novel polymorphs of 4-[3-chloro-4-(N?-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N?-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.
    Type: Grant
    Filed: December 8, 2018
    Date of Patent: February 1, 2022
    Assignee: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkata Panakala Rao Gogulapati, Rajeshwar Reddy Sagyam, Pavan Kumar Reddy Bandla, Srinivasulu Rangineni
  • Publication number: 20210403431
    Abstract: The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
    Type: Application
    Filed: December 6, 2017
    Publication date: December 30, 2021
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: THIRUMALAI RAJAN SRINIVASAN, ESWARAIAH SAJJA, VENKATA PANAKALA RAO GOGULAPATI, RAJESHWAR REDDY SAGYAM, SHYAM KIRAN BABU GANDHAM, RAJESHAM BOGE
  • Patent number: 11149026
    Abstract: The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2?-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: October 19, 2021
    Assignee: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan Srinivasan, Eswaraiah Sajja, Venkat Reddy Ghojala, Rajeshwar Reddy Sagyam, Srinivasulu Rangineni, Rajashekar Kommera, Markandeya Bekkam
  • Publication number: 20210188778
    Abstract: The present invention relates to novel polymorphs of 4-[3-chloro-4-(N?-cyclopropyl ureido) phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate represented by following structural formula-1a and process for preparation thereof. Further, the present invention relates to an improved process for the preparation of 4-[3-chloro-4-(N?-cyclopropylureido) phenoxy]-7-methoxyquinoline-6-carboxamide compound of formula-1 or its salts and its intermediates thereof.
    Type: Application
    Filed: December 8, 2018
    Publication date: June 24, 2021
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkata Panakala Rao GOGULAPATI, Rajeshwar Reddy SAGYAM, Pavan Kumar Reddy BANDLA, Srinivasulu RANGINENI
  • Publication number: 20210163410
    Abstract: The present invention relates to an improved process for the preparation of (2S)-2-[(4R)-2-oxo-4-propyltetrahydro-1H-pyrrol-1-yl] butanamide compound of formula-1, its intermediates, novel salt compounds of intermediates of the compound of formula-1. Further the use of novel salts in the preparation of the compound of formula-1. The present invention also relates to the novel process for the preparation of the compound of formula-1.
    Type: Application
    Filed: May 29, 2018
    Publication date: June 3, 2021
    Applicant: MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Satyanarayana REVU, Prabhakar CHERKUPALLY
  • Publication number: 20210155651
    Abstract: Water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous oxone solution at a pH-value within the alkaline range, where, when one maltodextrin is present, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is present, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency anaemia conditions.
    Type: Application
    Filed: April 4, 2019
    Publication date: May 27, 2021
    Applicant: MSN Laboratories Private Limited, R&D Center
    Inventors: Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Venkata Panakala Rao GOGULAPATI, Ganapathi Chary NAGUNURI, Mohammad Rafee SHAIK