Publication number: 20220315605
Abstract: The present invention provides pure (1?R,6R,6aR,7R,13S,14S,16R)-5-(acetyloxy)-3?,4?,6,6a,7,13,14,16-octahydro-6?,8,14-trihydroxy-7?,9-dimethoxy-4,10,23-trimethyl spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7, 8]isoquino[3,2-b][3] benzazocine-20,1?(211)-isoquinolin]-19-one of formula (1) substantially free from one or more impurities selected from intermediate compound of formula (50), cyclic impurity of formula (A), deshydroxy impurity of formula (B) and hydroxy impurity of formula (C).
Type:
Application
Filed:
June 29, 2020
Publication date:
October 6, 2022
Applicant:
MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
Inventors:
Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Rajeshwar Reddy SAGYAM, Navin Kumar Reddy KESHAVAREDDY
Publication number: 20220112212
Abstract: The present invention relates to novel crystalline polymorphs of sodium (4R,12aS)-9-{[(2,4-difluorophenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b] [1,3] oxazin-7-olate represented by the following structural formula-1a and process for their preparation. The present invention further relates to novel solvated forms of sodium (4R,12aS)-9-{[(2,4-difluoro phenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b][1,3] oxazin-7-olate compound of formula-1a and process for their preparation.
Type:
Application
Filed:
February 4, 2020
Publication date:
April 14, 2022
Applicant:
MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
Inventors:
Thirumalai Rajan SRINIVASAN, Eswaraiah SAJJA, Rajeshwar Reddy SAGYAM, Srinivasulu RAGINENI, Venkata Narasayya SALADI