Abstract: The present invention is directed to monoclonal antibodies and fragments thereof directed to LRP5/6 that find use in the prevention and treatment of cardiac remodeling and cancer. Also disclosed are methods for using such monoclonal antibodies in the prevention and treatment of such diseases.

Abstract: The present invention concerns a pyrvinium compound or an analog thereof for the treatment of cancers. This compound inhibits Wnt activity in the cells of cancers such as adrenocortical, hepatocellular, hepatoblastoma, malignant melanoma, ovarian, Wilm's tumor, Barrett's esophageal, glioma, bladder, breast, gastric, head & neck, lung cell, mesothelioma, and cervical cancers. The present invention also provides a method for assaying for compounds that alter Wnt pathway activity. Also provided are methods for treating Wnt-related non-cancer disease states.

Abstract: An inventive rearview assembly for a vehicle may comprise a mirror element and a display including a light management subassembly. The subassembly may comprise an LCD placed behind a transflective layer of the mirror element. Despite a low transmittance through the transflective layer, the inventive display is capable of generating a viewable display image having an intensity of at least 250 cd/m2 and up to 3500 cd/m2. The display includes a novel backlighting subassembly and novel optical components including a magnifying system, a depolarizer, a reflector, and a reflective polarizer. The display may be configured to display an image having edges contoured to correspond to the edges of the mirror element.