Patents by Inventor Ethan Schonbrun
Ethan Schonbrun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230314405Abstract: An example method includes: analyzing a clot curve for a test sample that is based on an assay performed on the test sample in order to obtain two or more parameters associated with the clot curve; analyzing the two or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample; and outputting, to a user interface, information based on the determination.Type: ApplicationFiled: December 22, 2022Publication date: October 5, 2023Inventors: Benjamin Horev, Ethan Schonbrun, Gert Blankenstein, Luisa Andruzzi, Anne Winkler, Jacqueline Scott
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Patent number: 11478796Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.Type: GrantFiled: October 9, 2017Date of Patent: October 25, 2022Assignees: ACOUSORT AB, INSTRUMENTATION LABORATORY COMPANYInventors: Per Augustsson, Pelle Daniel Ohlsson, Ola Jakobsson, Klara Andersson, Gert Blankenstein, Josef Kerimo, Ethan Schonbrun
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Publication number: 20210283607Abstract: The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.Type: ApplicationFiled: October 9, 2017Publication date: September 16, 2021Inventors: Per AUGUSTSSON, Pelle Daniel OHLSSON, Ola JAKOBSSON, Klara ANDERSSON, Gert BLANKENSTEIN, Josef KERIMO, Ethan SCHONBRUN
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Patent number: 10852295Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.Type: GrantFiled: April 12, 2019Date of Patent: December 1, 2020Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Gert Blankenstein, Josef Kerimo, Hansong Zeng
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Patent number: 10648907Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: GrantFiled: May 3, 2019Date of Patent: May 12, 2020Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20190257750Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: ApplicationFiled: May 3, 2019Publication date: August 22, 2019Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20190234931Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.Type: ApplicationFiled: April 12, 2019Publication date: August 1, 2019Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Gert Blankenstein, Josef Kerimo, Hansong Zeng
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Patent number: 10302559Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: GrantFiled: December 6, 2018Date of Patent: May 28, 2019Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Patent number: 10288600Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.Type: GrantFiled: May 15, 2017Date of Patent: May 14, 2019Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Gert Blankenstein, Josef Kerimo, Hansong Zeng
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Publication number: 20190107486Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: ApplicationFiled: December 6, 2018Publication date: April 11, 2019Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Patent number: 10168278Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: GrantFiled: October 5, 2017Date of Patent: January 1, 2019Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20180106720Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: ApplicationFiled: October 5, 2017Publication date: April 19, 2018Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20170336385Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.Type: ApplicationFiled: May 15, 2017Publication date: November 23, 2017Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Gert Blankenstein, Josef Kerimo, Hansong Zeng
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Patent number: 9601529Abstract: A nanowire array is described herein. The nanowire array comprises a substrate and a plurality of nanowires extending essentially vertically from the substrate; wherein: each of the nanowires has uniform chemical along its entire length; a refractive index of the nanowires is at least two times of a refractive index of a cladding of the nanowires. This nanowire array is useful as a photodetector, a submicron color filter, a static color display or a dynamic color display.Type: GrantFiled: February 26, 2015Date of Patent: March 21, 2017Assignees: ZENA TECHNOLOGIES, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Kwanyong Seo, Munib Wober, Paul Steinvurzel, Ethan Schonbrun, Yaping Dan, Kenneth Crozier
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Publication number: 20160344964Abstract: Methods, apparatuses, systems, and devices relating to fabricating one or more nanowires are disclosed. One method for fabricating a nanowire includes: selecting a particular wavelength of electromagnetic radiation for absorption for a nanowire; determining a diameter corresponding to the particular wavelength; and fabricating a nanowire having the determined diameter. According to another embodiment, one or more nanowires may be fabricated in an array, each having the same or different determined diameters. An image sensor and method of imaging using such an array are also disclosed.Type: ApplicationFiled: August 1, 2016Publication date: November 24, 2016Inventors: Kwanyong Seo, Paul Steinvurzel, Ethan Schonbrun, Munib Wober, Kenneth B. Crozier
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Patent number: 9406709Abstract: Methods, apparatuses, systems, and devices relating to fabricating one or more nanowires are disclosed. One method for fabricating a nanowire includes: selecting a particular wavelength of electromagnetic radiation for absorption for a nanowire; determining a diameter corresponding to the particular wavelength; and fabricating a nanowire having the determined diameter. According to another embodiment, one or more nanowires may be fabricated in an array, each having the same or different determined diameters. An image sensor and method of imaging using such an array are also disclosed.Type: GrantFiled: December 13, 2010Date of Patent: August 2, 2016Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, ZENA TECHNOLOGIES, INC.Inventors: Kwanyong Seo, Paul Steinvurzel, Ethan Schonbrun, Munib Wober, Kenneth B. Crozier
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Publication number: 20160124250Abstract: Methods and apparatus using generating multiple color images in a single exposure. In one implementation, an imaging apparatus is provided that includes an image sensor array including a plurality of image sensor elements. The imaging apparatus also includes a dispersive element configured to rotate incident linearly polarized radiation by a rotation angle to produce rotated linearly polarized radiation having at least two polarization angles, wherein the rotation angle is determined based, at least in part, on a wavelength of the incident linearly polarized radiation. The imaging apparatus also includes a pixelated polarizing filter configured to receive the rotated linearly polarized radiation from the dispersive element and selectively pass the rotated linearly polarized radiation to the image sensor array, wherein the rotated linearly polarized radiation is selectively passed based on the polarization angle of the rotated linearly polarized radiation.Type: ApplicationFiled: May 23, 2014Publication date: May 5, 2016Applicant: President and Fellows of Harvard CollegeInventors: Ethan Schonbrun, Giuseppe Di Caprio, Gudfridur Möller, Richard Christopher Stokes
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Publication number: 20150171244Abstract: A nanowire array is described herein. The nanowire array comprises a substrate and a plurality of nanowires extending essentially vertically from the substrate; wherein: each of the nanowires has uniform chemical along its entire length; a refractive index of the nanowires is at least two times of a refractive index of a cladding of the nanowires. This nanowire array is useful as a photodetector, a submicron color filter, a static color display or a dynamic color display.Type: ApplicationFiled: February 26, 2015Publication date: June 18, 2015Inventors: Kwanyong Seo, Munib Wober, Paul Steinvurzel, Ethan Schonbrun, Yaping Dan, Kenneth Crozier
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Patent number: 9000353Abstract: A nanowire array is described herein. The nanowire array comprises a substrate and a plurality of nanowires extending essentially vertically from the substrate; wherein: each of the nanowires has uniform chemical along its entire length; a refractive index of the nanowires is at least two times of a refractive index of a cladding of the nanowires. This nanowire array is useful as a photodetector, a submicron color filter, a static color display or a dynamic color display.Type: GrantFiled: October 22, 2010Date of Patent: April 7, 2015Assignees: President and Fellows of Harvard College, Zena Technologies, Inc.Inventors: Kwanyong Seo, Munib Wober, Paul Steinvurzel, Ethan Schonbrun, Yaping Dan, Kenneth B. Crozier
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Patent number: 8879147Abstract: Microscopy methods and apparatus in which one or more microfabricated optical elements (e.g., one or more Fresnel zone plates) operate as one or an array of objective lenses. A single object or a plurality of objects may be scanned in parallel. A single, low-numerical-aperture relay optic can be used with the one or more optical elements eliminating the need for one or more confocal pinhole apertures. When an array of optical elements is used, hundreds to thousands of objects can be imaged or inspected simultaneously onto a two-dimensional imaging device, such as a CCD array. The microfabricated optical elements can be readily configured for imaging with a solid immersion medium. Imaging resolutions on the order of one wavelength of the illumination source, and less, can be achieved.Type: GrantFiled: May 7, 2010Date of Patent: November 4, 2014Assignee: President and Fellows of Harvard CollegeInventors: Ethan Schonbrun, Kenneth B. Crozier