Abstract: Dynamic monitoring of an element in a network is provided by predicting whether a resource threshold crossing, such as load-based level, is likely to be exceeded within a certain time period. If the level is likely to be exceeded shortly, the monitoring rate of the element for a given time period may be increased. Conversely, if the level is unlikely to be exceeded in the near term, the monitoring rate may be decreased.

Abstract: A goal evaluation capability is provided. A resource allocation request of a customer is received. The resource allocation request includes a request for allocation of resources of a distributed system of a provider, a set of customer constraints, and a customer goal. A set of feasible resource allocations for the customer is determined based on the set of customer constraints and on information associated with the distributed system. The set of feasible resource allocations includes a plurality of feasible resource allocations. A provider goal function associated with a provider goal of the provider is determined. A customer goal function associated with the customer goal of the customer is determined. A feasible resource allocation is selected for the customer, from the set of feasible resource allocations, based on the provider goal function and the customer goal function.

Abstract: A client device requests permission from a network access device to access a network associated with the network access device. The client device sends credentials of a user associated with the client device for authenticating with the network access device. The client device receives from the network access device permission to access the network along with a session certificate and an associated key. The session certificate and the key are associated with the credentials of the user. The client device establishes a network session using the network based on receiving the permission. During the network session, the client device establishes a secure communications channel with a website. The client device authenticates the user to the website by sending the session certificate to the website over the secure communications channel. The client device then receives permission from the website to access contents of the website.

Abstract: Provided is a method for directing differentiation of neural progenitors with a caudal and ventral specification into motor neurons including culturing neural progenitors in a culturing medium including a basic medium supplemented by at least one inhibitor of the Notch signaling pathway whereby the neural progenitors differentiate into postmitotic motor neurons. The resulting motor neurons may be used for drug development, as carriers, e.g. for gene therapy of protein delivery as well as for transplantation for the purpose of treating a motor neuron disease.

Abstract: Various exemplary embodiments relate to a method and related network node including one or more of the following: receiving, from a requesting device, a request to establish a component of an application; identifying a policy file associated with the application, wherein the policy file defines at least one segment for the application and defines at least one constraint for a first segment of the at least one segment; selecting the first segment for establishment of the component; selecting a location for establishment of the component, wherein the location is selected to be consistent with the at least one constraint; and establishing the component at the selected location.

Abstract: Provided are systems and methods for providing human cell cultures. Further provided are cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well as for the development of somatic cells cultures from stem cells, the somatic cell cultures being free of extraembryonic cells.

Abstract: The present invention provides a method for directing differentiation of neural progenitors with a caudal and ventral specification into motor neurons comprising culturing neural progenitors in a culturing medium comprising a basic medium supplemented by at least one inhibitor of the Notch signaling pathway whereby said neural progenitors differentiate into postmitotic motor neurons. The resulting motor neurons may be used for drug development, as carriers, e.g. for gene therapy of protein delivery as well as for transplantation for the purpose of treating a motor neuron disease.

Abstract: The present invention concerns systems and methods for providing human cell cultures. Specific embodiments of the invention relate to cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well as for the development of somatic cells cultures from stem cells, the somatic cell cultures being free of extraembryonic cells.

Abstract: A process is disclosed for the production of particles comprising at least one core of core material containing perfume absorbed therein, the core being coated with at least one water-soluble encapsulating material that is impervious to the said perfume, wherein the process comprises: mixing at least one water-soluble encapsulating material, an aqueous solution, at least one core material and at least one perfume to produce a slurry thereof; heating the slurry to reduce the water content thereof, so as to produce a molten or rubbery mass from the slurry, wherein heating is effected at least in part in a pre-heater (122); extruding the molten or rubbery mass through a die (24); and physically processing the extruded material to produce particles.

Abstract: Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated I?B by interfering, directly or indirectly, with the ability of ?-TrCP/E3RS to engage in protein-protein association involving hnRNP-U, are useful as drugs for treating conditions associated with NF-?B activation. Cellular and non-cellular screening methods for identifying such compounds are based on monitoring the association/dissociation of ?-TrCP/E3RS.

Abstract: Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated I&kgr;B by interfering, directly or indirectly, with the ability of &bgr;-TrCP/E3RS to engage in protein-protein association involving hnRNP-U, are useful as drugs for treating conditions associated with NF-&kgr;B activation. Cellular and non-cellular screening methods for identifying such compounds are based on monitoring the association/dissociation of &bgr;-TrCP/IE3RS.