Abstract: Systems and methods here may include a modular battery pack including a housing, and within the housing: individual battery cells arranged in rows, a circuit board at one end of the housing configured to manage a thermal condition of the battery pack, heat sensors in communication with the circuit board, an enclosed heat pipe arrangement in a corrugated configuration arranged between each row of battery cells within the housing, and a fan and/or Peltier heat sink configured at one end of the battery pack housing, in communication with the circuit board.

Abstract: A load sensor compares generated values of load signals to predicted values of the load signals. Where an error between a generated value and a predicted value is less than a threshold, a value of zero is transmitted by the load sensor to an external systems, in an encoded stream of bits, and the error are used to calculate a predicated value of a next load signal, such that insubstantial changes in loading resulting in small errors are not transmitted to the external system. Where an error between the generated value and the predicted value exceeds the threshold, however, a value representative of the error is transmitted to the external system, in an encoded stream of bits. The external system processes the stream of bits to calculate the error, to determine that an item has been placed on a storage system or removed therefrom, or to identify the item.

Abstract: This disclosure provides systems and methods for the on-demand synthesis, separation, purification and formulation of chemicals, and particularly for the on-demand production of pharmaceutical products. More particularly, the disclosure provides continuous-flow on-demand systems, comprising one or more reagent holding/dispensing containers, continuous-flow chemical synthesis modules and/or one or more separation, crystallization, filtration, wash and/or formulation modules, additionally comprising automated detection systems and methods for monitoring reagents, products and processing parameters and automated control systems and methods for controlling processing conditions and parameters.

Abstract: The present invention relates to a front door refrigerator for enabling a delivery man to safely deliver delivery goods to an orderer even when a user having ordered an item or fresh food is not at home, and preventing the delivery goods from becoming lost during delivery.

Abstract: An apparatus includes a platform or other accessory that is supported by one or more transducer assemblies using piezoelectric transducers. In one implementation, a saddle structure provides mechanical support to a platform while transferring force from a load onto a portion to which a pair of piezoelectric transducers are affixed. As a load on the saddle changes, the resulting change in strain on the portion produces signals from the piezoelectric transducers. In another implementation a beam provides mechanical support to a platform or other accessory. A pair of piezoelectric transducers are affixed near a strain concentrator, such as a hole in the beam, produce signals indicative of a change in load on the beam.

Abstract: An impulse strip including a plurality of clips, hooks or other features for attaching items to the impulse strip also includes a plurality of switches associated with each of the clips, hooks or other features. The switches are in communication with illuminators or other indicators that are arranged in an array. When an item is loaded onto the strip, or removed from the strip, a switch may be opened or closed, causing one of the illuminators in the array to be activated or deactivated accordingly. An image captured of the illuminators is processed to determine which of the illuminators is activated and which is deactivated, and an inventory level of the strip may be determined based on the statuses of the respective illuminators corresponding to the clips, the hooks or the other features of the impulse strip.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: Systems and methods here may include a modular battery pack including a housing, and within the housing: individual battery cells arranged in rows, a circuit board at one end of the housing configured to manage a thermal condition of the battery pack, heat sensors in communication with the circuit board, an enclosed heat pipe arrangement in a corrugated configuration arranged between each row of battery cells within the housing, and a fan and/or Peltier heat sink configured at one end of the battery pack housing, in communication with the circuit board.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: Disclosed herein are methods of using immune cells expressing chimeric receptors and two or more anti-cancer antibodies that bind cancer antigens in cancer therapy.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: Disclosed herein are methods of using immune cells expressing chimeric receptors and bipartite targeting ligands for immunotherapy of cancer and other diseases.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: A handheld device including a circuit board including at least one electronic component, a heat pipe disposed on the electronic component to absorb heat generated from the electronic component and to release the absorbed heat in a direction opposite to the electronic component, and a heat sinking material configured to bond the circuit board and the heat pipe to each other. The heat pipe includes an evaporation section disposed on the main processor to absorb heat generated from the main processor, a connection section disposed on a side region of the main board to transfer the absorbed heat in a direction opposite to the main processor, and a condensation section configured to release the transferred heat.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

Abstract: A handheld device including a circuit board including at least one electronic component, a heat pipe disposed on the electronic component to absorb heat generated from the electronic component and to release the absorbed heat in a direction opposite to the electronic component, and a heat sinking material configured to bond the circuit board and the heat pipe to each other. The heat pipe includes an evaporation section disposed on the main processor to absorb heat generated from the main processor, a connection section disposed on a side region of the main board to transfer the absorbed heat in a direction opposite to the main processor, and a condensation section configured to release the transferred heat.

Abstract: Embodiments of the invention provide a stretchable sleeve having a medicinal section that can be loaded with a medicinal composition and a perforated section comprising a plurality of openings, wherein the medicinal section and the perforated section overlap, and wherein the sleeve is sized so that the interior surface of the medicinal section comfortably fits a body portion and the medicinal section contacts the body portion at the site of pain. Embodiments of the invention also provide methods for preparing a sleeve by applying a medicinal composition to the inner surface of the medicinal section through the openings at the perforated section. Embodiments of the invention also provide methods for relieving pain in a body portion by pulling the sleeve in an outside-out configuration straight up a body portion without having to roll and flip its exterior surface outside.

Abstract: Embodiments of the invention provide a stretchable sleeve having a medicinal section that can be loaded with a medicinal composition and a perforated section comprising a plurality of openings, wherein the medicinal section and the perforated section overlap, and wherein the sleeve is sized so that the interior surface of the medicinal section comfortably fits a body portion and the medicinal section contacts the body portion at the site of pain. Embodiments of the invention also provide methods for preparing a sleeve by applying a medicinal composition to the inner surface of the medicinal section through the openings at the perforated section. Embodiments of the invention also provide methods for relieving pain in a body portion by pulling the sleeve in an outside-out configuration straight up a body portion without having to roll and flip its exterior surface outside.

Abstract: The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.

Abstract: Embodiments of the invention provide a stretchable sleeve having a medicinal section that can be loaded with a medicinal composition and a perforated section comprising a plurality of openings, wherein the medicinal section and the perforated section overlap, and wherein the sleeve is sized so that the interior surface of the medicinal section comfortably fits a body portion and the medicinal section contacts the body portion at the site of pain. Embodiments of the invention also provide methods for preparing a sleeve by applying a medicinal composition to the inner surface of the medicinal section through the openings at the perforated section. Embodiments of the invention also provide methods for relieving pain in a body portion by pulling the sleeve in an outside-out configuration straight up a body portion without having to roll and flip its exterior surface outside.