Abstract: The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or APRIL-related disorders.

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD5, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fc?R or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

Abstract: Methods are disclosed for assessing the condition of a cartilage in a joint, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. Information o thickness of cartilage and curvature of cartilage or subchondral bone can be used to plan therapy. Information on movement pattern can be used to plan therapy.

Abstract: A device and technique are presented to calibrate an imaging device for generating three-dimensional surface models of moving objects and calculating three-dimensional coordinates of detected features relative to a coordinate system embedded in the device. The internal projector and camera parameters, i.e., zoom, focus, aperture, optical center, logical pixel size, aspect ratio, are determined for all projectors and cameras and all possible focal planes of the device in operation.

Abstract: A device and method for producing a model of the surface of one aspect of a three dimensional object. The model is produced by extracting a three dimensional mesh from a pattern projected on the object. The three dimensional object maybe in motion.

Abstract: A system and method are presented for calibrating a set of imaging devices for generating three dimensional surface models of moving objects and calculating three dimensional coordinates of detected features in a laboratory coordinate system, when the devices and objects are moving in the laboratory coordinate system. The approximate location and orientation of the devices are determined by one of a number of methods: a fixed camera system, or an attitude sensor coupled with an accelerometer, a differential GPS approach, or a timing based system. The approximate location and orientation of the device is then refined using to a very highly accurate determination using an iterative approach and de-focusing calibration information.

Abstract: A method is presented that allows multiple devices for generating three dimensional surface models of moving objects to be used simultaneously. A timing pattern is used to control and trigger the devices in order to operate seven of the devices without interference. In one embodiment, a method of employing optical filters is also described that then allows operation of forty nine of the devices at the same time if the normal visible spectrum is to be used for simultaneous video acquisition. In another embodiment, if no simultaneous video acquisition is required, the optical filtering technique can support up to one hundred fifty four imaging devices operating simultaneously.

Abstract: Methods are disclosed for assessing the condition of a cartilage in a joint and assessing cartilage loss, particularly in a human knee. The methods include converting an image such as an MRI to a three dimensional map of the cartilage. The cartilage map can be correlated to a movement pattern of the joint to assess the affect of movement on cartilage wear. Changes in the thickness of cartilage over time can be determined so that therapies can be provided. The amount of cartilage tissue that has been lost, for example as a result of arthritis, can be estimated.

Abstract: A door retaining device having particular application for preventing unauthorized removal of vending machine doors from vending machine housings. The door retaining device is fixedly secured at a first end to the vending machine door, and cooperates with the vending machine housing at a second end to permit rotation of the door relative to the housing about at least one hinge pin, but to substantially prevent movement of the door relative to the housing other than rotation about the at least one hinge pin. The door retaining device has a hook portion at the second end that extends into the housing through an aperture in the housing. The hook portion engages the housing to prevent movement of the door relative to the housing other than rotation about the at least one hinge pin.

Abstract: A door retaining device is provided having particular application for preventing unauthorized removal of vending machine doors from vending machine housings. The door retaining device is fixedly secured at a first end to the vending machine door, and cooperates with the vending machine housing at a second end to permit rotation of the door relative to the housing about at least one hinge pin, but to substantially prevent movement of the door relative to the housing other than rotation about the at least one hinge pin. The door retaining device has a hook portion at the second end that extends into the housing through an aperture in the housing. The hook portion engagesthe housing to prevent movement of the door relative to the housing other than rotation about the at least one hinge pin.