Patents by Inventor Eugene D. Kwon

Eugene D. Kwon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
    Patent number: 11939378
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: March 26, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
    Patent number: 11242387
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: February 8, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
    Publication number: 20210380690
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Application
    Filed: August 13, 2021
    Publication date: December 9, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • Methods for treating cancer in patients with elevated levels of Bim
    Patent number: 11136393
    Abstract: Materials and methods for treating cancer, including materials and methods for treating cancer in patients identified as having elevated levels of Bim.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: October 5, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Haidong Dong, Susan M. Harrington, Eugene D. Kwon, Christopher J. Krco, Xin Liu
  • Soluble B7-H1
    Publication number: 20200326344
    Abstract: This document features methods of evaluating mammals by assessing expression of B7-H1 in a body fluid.
    Type: Application
    Filed: March 23, 2020
    Publication date: October 15, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Eugene D. Kwon, Haidong Dong, Xavier Frigola Baro, Brant A. Inman
  • COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
    Publication number: 20200002419
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Application
    Filed: August 19, 2019
    Publication date: January 2, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • METHODS FOR TREATING CANCER IN PATIENTS WITH ELEVATED LEVELS OF BIM
    Publication number: 20190315869
    Abstract: Materials and methods for treating cancer, including materials and methods for treating cancer in patients identified as having elevated levels of Bim.
    Type: Application
    Filed: April 15, 2019
    Publication date: October 17, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Haidong Dong, Susan M. Harrington, Eugene D. Kwon, Christopher J. Krco, Xin Liu
  • Methods for treating cancer in patients with elevated levels of BIM
    Patent number: 10259875
    Abstract: Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: April 16, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Haidong Dong, Susan M. Harrington, Eugene D. Kwon, Christopher J. Krco, Xin Liu
  • Methods and materials for treating cancer
    Patent number: 10167336
    Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells having the potential to exert anti-cancer effects are provided. In addition, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells and administering a PD-1 inhibitor to such a mammal are provided.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: January 1, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Haidong Dong, Eugene D. Kwon, Svetomir N. Markovic, Christopher J. Krco
  • COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
    Publication number: 20180179281
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Application
    Filed: February 6, 2018
    Publication date: June 28, 2018
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
    Publication number: 20180100015
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Application
    Filed: September 29, 2017
    Publication date: April 12, 2018
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • Soluble B7-H1
    Publication number: 20170363634
    Abstract: This document features methods of evaluating mammals by assessing expression of B7-H1 in a body fluid.
    Type: Application
    Filed: August 31, 2017
    Publication date: December 21, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Eugene D. Kwon, Haidong Dong, Xavier Frigola Baro, Brant A. Inman
  • Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target
    Patent number: 9803015
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: October 31, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • B7-H3 IN CANCER
    Publication number: 20170146539
    Abstract: Methods of determining the prognosis of a subject with cancer and determining risk of cancer progression by assessing expression of B7-H3. Methods of reducing B7-H3 levels and/or activity.
    Type: Application
    Filed: February 6, 2017
    Publication date: May 25, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Eugene D. Kwon, Christine M. Lohse, Yuri Sheinin, Timothy J. Roth, Susan M. Harrington
  • COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
    Publication number: 20160264667
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Application
    Filed: September 1, 2015
    Publication date: September 15, 2016
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
    Publication number: 20160257953
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Application
    Filed: March 14, 2016
    Publication date: September 8, 2016
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • METHODS FOR TREATING CANCER IN PATIENTS WITH ELEVATED LEVELS OF BIM
    Publication number: 20160251437
    Abstract: Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD 1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.
    Type: Application
    Filed: September 3, 2014
    Publication date: September 1, 2016
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Haidong Dong, Susan M. Harrington, Eugene D. Kwon, Christopher J. Krco, Xin Liu
  • COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET
    Publication number: 20160245816
    Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
    Type: Application
    Filed: February 18, 2016
    Publication date: August 25, 2016
    Inventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
  • METHODS AND MATERIALS FOR TREATING CANCER
    Publication number: 20160176967
    Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells having the potential to exert anti-cancer effects are provided. In addition, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells and administering a PD-1 inhibitor to such a mammal are provided.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 23, 2016
    Inventors: Haidong Dong, Eugene D. Kwon, Svetomir N. Markovic, Christopher J. Krco
  • B7-H1 AND SURVIVIN IN CANCER
    Publication number: 20160154000
    Abstract: Methods of determining prognosis of a subject with cancer by assessing expression of B7-H1 and survivin in combination.
    Type: Application
    Filed: February 9, 2016
    Publication date: June 2, 2016
    Inventors: Eugene D. Kwon, John C. Cheville, Amy Krambeck, Susan M. Harrington, Robert H. Thompson, Haidong Dong, Christine M. Lohse, Alexander S. Parker