Abstract: Provided herein is a method for producing an antibody, such as an anti-TNF? antibody (e.g., infliximab) having a C-terminal lysine content of about 20% to about 70%, and a sialic acid content of about 1% to about 20%, comprising culturing a zinc-responsive host cell transfected with DNA encoding the antibody in a culture medium comprising at least 0.5 ?M zinc; and controlling the concentration of zinc in the culture medium, thereby producing the antibody.

Abstract: Provided herein is a method for producing an antibody, such as an anti-TNF? antibody (e.g., infliximab) having a C-terminal lysine content of about 20% to about 70%, and a sialic acid content of about 1% to about 20%, comprising culturing a zinc-responsive host cell transfected with DNA encoding the antibody in a culture medium comprising at least 0.5 ?M zinc; and controlling the concentration of zinc in the culture medium, thereby producing the antibody.

Abstract: Provided herein is a method for producing an antibody, such as an anti-TNF? antibody (e.g., infliximab) having a C-terminal lysine content of about 20% to about 70%, and a sialic acid content of about 1% to about 20%, comprising culturing a zinc-responsive host cell transfected with DNA encoding the antibody in a culture medium comprising at least 0.5 ?M zinc; and controlling the concentration of zinc in the culture medium, thereby producing the antibody.

Abstract: Provided herein is a method for producing an antibody, such as an anti-TNF? antibody (e.g., infliximab) having a C-terminal lysine content of about 20% to about 70%, and a sialic acid content of about 1% to about 20%, comprising culturing a zinc-responsive host cell transfected with DNA encoding the antibody in a culture medium comprising at least 0.5 ?M zinc; and controlling the concentration of zinc in the culture medium, thereby producing the antibody.

Abstract: Portland Cement-based concretes and mortars exhibit significant reduction in shrinkage cracking when combined with Magnesium Oxide (MgO), Shrinkage Reduction Admixtures (SRA) and Super Absorbent Polymers (SAP). However, MgO is a solid that reacts with water, SRA is a liquid, and SAP if not added properly could pull water out of the system and thus increase shrinkage. Unique admixture blends used as supplementary cementing materials that do not significantly affect concrete or cement strength properties of Portland cement itself address such issues. Proper ratios of MgO, SRA and/or SAP perform better against crack reduction when compared to commonly used Expansive Cements (EC).

Abstract: A reflector with an alignment recess is provided. The reflector has a recess portion that receives the base of a light emitting diode. At least a portion of an outer periphery of the base of the light emitting diode is adjacent at least portions of the recess portion of the reflector.

Abstract: A lens frame for mounting and cooling LEDs is described. The lens frame (120) may be continuous and attachable to a luminaire (100) having a luminaire housing (110) with an opening (112). The lens frame (120) may extend across and close the opening (112) of the luminaire housing (110). The lens frame (120) may include a recessed support surface (122), a lens attachment area (126) positioned outward from and peripherally of the support surface (122), and heat dissipating structure (130) located peripherally of the support surface (122). A plurality of LEDs (154) may be coupled to the support surface (122) of the lens frame (120) exteriorly of the luminaire housing (110) and a lens (188) may be coupled to the lens retaining area (126) of the lens frame (120).

Abstract: A reflector with an alignment recess is provided. The reflector has a recess portion that receives the base of a light emitting diode. At least a portion of an outer periphery of the base of the light emitting diode is adjacent at least portions of the recess portion of the reflector.

Abstract: The present disclosure is directed to inventive methods and apparatus for a lighting unit having a plurality of substantially linearly arranged solid state light sources (34, 134, 234, 334). A first reflector (40, 140, 240, 340) and a second reflector (50, 150, 250, 350) flank the solid state light sources (34, 134, 234, 334). A lens (60, 160, 260, 360) is provided over and spaced apart from a plurality of the solid state light sources (34, 134, 234, 334).

Abstract: Portland Cement-based concretes and mortars exhibit significant reduction in shrinkage cracking when combined with Magnesium Oxide (MgO), Shrinkage Reduction Admixtures (SRA) and Super Absorbent Polymers (SAP). However, MgO is a solid that reacts with water, SRA is a liquid, and SAP if not added properly could pull water out of the system and thus increase shrinkage. Unique admixture blends used as supplementary cementing materials that do not significantly affect concrete or cement strength properties of Portland cement itself address such issues. Proper ratios of MgO, SRA and/or SAP perform better against crack reduction when compared to commonly used Expansive Cements (EC).

Abstract: A reflector with an alignment recess is provided. The reflector has a recess portion that receives the base of a light emitting diode. At least a portion of an outer periphery of the base of the light emitting diode is adjacent at least portions of the recess portion of the reflector.

Abstract: An LED optical assembly is provided having a heatsink, a support surface having a plurality of light emitting diodes, a plurality of reflectors, and a plurality of optical lenses. The heatsink is in thermal connectivity with the support surface. Each reflector is positioned over a corresponding light emitting diode and at least one optical lens is placed over a corresponding reflector.

Abstract: An LED optical assembly is provided having a support surface having a plurality of light emitting diodes, a plurality of reflectors, and a plurality of optical lenses. Each reflector is positioned over a corresponding light emitting diode and at least one optical lens is placed over a corresponding reflector.

Abstract: A lens frame for mounting and cooling LEDs is described. The lens frame (120) may be continuous and attachable to a luminaire (100) having a luminaire housing (110) with an opening (112). The lens frame (120) may extend across and close the opening (112) of the luminaire housing (110). The lens frame (120) may include a recessed support surface (122), a lens attachment area (126) positioned outward from and peripherally of the support surface (122), and heat dissipating structure (130) located peripherally of the support surface (122). A plurality of LEDs (154) may be coupled to the support surface (122) of the lens frame (120) exteriorly of the luminaire housing (110) and a lens (188) may be coupled to the lens retaining area (126) of the lens frame (120).

Abstract: An LED optical assembly is provided having a heatsink, a support surface having a plurality of light emitting diodes, a plurality of reflectors, and a plurality of optical lenses. The heatsink is in thermal connectivity with the support surface. Each reflector is positioned over a corresponding light emitting diode and at least one optical lens is placed over a corresponding reflector.

Abstract: An LED optical assembly is provided having a support surface having a plurality of light emitting diodes, a plurality of reflectors, and a plurality of optical lenses. Each reflector is positioned over a corresponding light emitting diode and at least one optical lens is placed over a corresponding reflector.

Abstract: A reflector with an alignment recess is provided. The reflector has a recess portion that receives the base of a light emitting diode. At least a portion of an outer periphery of the base of the light emitting diode is adjacent at least portions of the recess portion of the reflector.

Abstract: A light fixture device comprises a reflector portion having a pair of parallel longitudinal boundary regions and a pair of parallel lateral boundary regions; the reflector portion being shaped according to a longitudinal focal line, a pair of housing portions, each for engaging a corresponding lateral boundary region; at least one connector portion for coupling the housing portions together with the reflector portion.

Abstract: Calculating, detecting, observing, and validating operating characteristics, conditions, and metrics, especially quality of service metrics, of a system. The quality of service metrics are reported and utilized to manage the service. The various elements of the system for generating the quality of service metrics are integrated, with the same or substantially the same schema and metadata in the databases management systems of the externalized metric configuration data database, and the raw transaction data database. There is extensive code reuse, with the various engines, as the standard requirements methodology engine and thee standardized extensible calculation engine utilizing the same classes or objects, and as appropriate, the same function calls, interfaces, api's, and the like.

Abstract: A computerized method, program product, and a service that discovers trace data inserted into a source database having an unknown schema. Once the trace data is found by a dynamic data discovery engine, the tables, the fields, and the attributes of the fields in the source schema in which the trace data were located can be evaluated to determine if the data in the fields are pertinent to a target database. If so, then the data in those fields can be mapped and transferred to a target database. The dynamic data discovery engine generates the commands in both the source and the target database command language to find all pertinent data, map and transfer the data from the source database to a target database. The dynamic data discovery engine generates commands to create the target database and/or fields within an existing target database for the mapped and transferred data.