Abstract: The present disclosure provides a medical device comprising an actuator restraining assembly configured to assist in restraining a catheter shaft in a deflected configuration. The actuator restraining assembly may include a brake element, a release element, a connecting sheath, and a connecting rod disposed in a catheter handle, wherein the connecting sheath and connecting rod are attached to an actuator mechanism, and wherein the at brake element is attached to the connecting sheath and the release element is attached to the connecting rod. The brake element is sized and configured to contact an inner wall of the handle to thereby provide resistance to movement of actuator mechanism in a proximal direction with respect to the handle. In one embodiment, the actuator restraining assembly is configured to allow for temporary, i.e., reversible, restraining of the catheter shaft in the deflected configuration.

Abstract: A fat harvesting system and related methods of harvesting and reinjecting fat that provides a medical professional with multiple technique options. Harvested fat can be subjected to a variety of pre-reinjection preparation steps within a single, self-contained reservoir such that the potential for contaminating the harvested fat is avoided. The fat harvesting system can be completely self-contained kit requiring no additional external systems or alternatively, can utilize available surgical suite systems, for example, vacuum to successfully harvest, prepare and reinject fat cells. The fat harvesting system can size harvested fat cells so as to be especially desirable for different injection locations in the body. The fat harvesting system is a single use, disposable system that requires no sterilization equipment and recovered and sized fat cells are maintained in a sanitary environment so as to avoid contamination that could result in having to discard recovered fat cells.

Abstract: The teachings herein provide an instrument comprising a forceps. The forceps comprise a hand piece; a tubular member connected to the hand piece; and a jaw assembly connected to the hand piece. The jaw assembly includes a first jaw element and a second jaw element. The first jaw element includes a gripping section and a flexing section. The flexing section includes an arcuate section. The second jaw element opposes the first jaw element and includes a gripping section. The tubular member is moveable onto the arcuate section of the first jaw element so that the flexing section of the first jaw element is flexed and the jaw assembly is moved into a closed position. The first jaw element, the second jaw element, or both include a stiffening spine so that the jaw assembly is substantially rigid in the closed position.

Abstract: Embodiments of a canister for a negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, the canister includes a receptacle for receiving wound exudate. A filter stack is interposed between the receptacle and the pump assembly and provides a fluid flow path therebetween. The flow path is more easily navigable by gas than by liquid, thereby allowing the pump assembly to apply a negative pressure to the canister without aspirating wound exudate into filters housed within the filter stack.

Abstract: A method of treating a subject can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent, thereby disrupting KLRG1 signaling and activating CD8+ cytotoxic T and/or NK cells. A method of treating cancer can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent. The methods can treat various cancers, for example melanoma, lung cancer, pancreatic cancer, glioma, breast cancer, and ovarian cancer.

Abstract: The receptor killer cell lectin-like receptor G1 (KLRG1) is expressed on T and NK cells, which binds to ligands on epithelial and mesenchymal cells. The ligand for KLRG1 has been described to be E-cadherin, N-cadherin, and R-cadherin. The present disclosure relates to and results from the discovery and characterization of antibodies that bind the extracellular domain (ECD) of KLRG1 but do not interfere with its interaction with the ligands E-cadherin, N-cadherin, and R-cadherin. The antibodies described have been derived by mouse hybridoma technology, and can be humanized by grafting their complementary determining regions (CDRs) into a human framework. The antibodies described can be used as effective therapeutic agents. Various antibodies, or antigen-binding fragments of such antibodies, along with various therapeutic and/or diagnostic methods, among other features, are provided for in the present disclosure.

Abstract: A smart speaker power controller may be configured to receive power conforming to one of a plurality of power modes from an input power source. The power controller may be further configured to communicate the power mode to at least one component of a processing system or at least one component of an audio system for operating the smart speaker according to the received power mode, including determining a current limit of a power converter; determining a shutdown voltage threshold and safely shutting down the smart speaker if the input voltage falls below the threshold, and/or modifying audio operation of the smart speaker in response to the power mode. The smart speaker can further include an audio power supply controller configured to monitor energy required to reproduce an audio signal and to servo a power supply voltage provided to an audio amplifier in response to this energy level.

Abstract: The receptor killer cell lectin-like receptor G1 (KLRG1) is expressed on T and NK cells, which binds to ligands on epithelial and mesenchymal cells. The ligand for KLRG1 has been described to be E-cadherin, N-cadherin, and R-cadherin. The present disclosure relates to and results from the discovery and characterization of antibodies that bind the extracellular domain (ECD) of KLRG1 but do not interfere with its interaction with the ligands E-cadherin, N-cadherin, and R-cadherin. The antibodies described have been derived by mouse hybridoma technology, and can be humanized by grafting their complementary determining regions (CDRs) into a human framework. The antibodies described can be used as effective therapeutic agents. Various antibodies, or antigen-binding fragments of such antibodies, along with various therapeutic and/or diagnostic methods, among other features, are provided for in the present disclosure.

Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to killer cell lectin-like receptor G1 (KLRG1). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes including treatment of cancers and to increase the effectiveness of vaccines.

Abstract: A method of treating a subject can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent, thereby disrupting KLRG1 signaling and activating CD8+ cytotoxic T and/or NK cells. A method of treating cancer can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent. The methods can treat various cancers, for example melanoma, lung cancer, pancreatic cancer, glioma, breast cancer, and ovarian cancer.

Abstract: A fluid delivery system for dispensing fluid can include a dispenser, such as a trigger engine-type dispenser, configured to draw fluid up from a container. A nozzle assembly can include a nozzle, and a nozzle slide. The nozzle slide can be configured to slide and/or rotate relative to the shroud to provide different dispensing modes. In alternative examples, the nozzle can be configured to rotate in 30 degree increments relative to the shroud to provide the different dispensing modes or the nozzle assembly can include a nozzle extension, and the nozzle extension can be configured to rotate relative to the shroud to provide different dispensing patterns out of the nozzle. In another example a first nozzle can be configured to provide one or more dispensing modes, and a second nozzle can be configured to provide a different dispensing mode than the first nozzle. Methods of dispensing fluids and methods of assembling fluid dispensers are also disclosed.

Abstract: A motor vehicle system for generating and transmitting motor vehicle imaging object data includes a communication system module positioned in a host vehicle receiving vehicle attribute data during host vehicle highway travel and preparing a fused object attribute data for transmission. An imaging device collects object imaging data representing objects within a visible detection range of the imaging device. An object detection and classification system module has an object classification sub-module used to classify the objects within the visible detection range as a vehicle type or a pedestrian and to output each as an object attribute data. A target fusion module receives the object attribute data from the object detection and classification system module, fuses the object attribute data with the vehicle attribute data to create the fused object attribute data, and forwards the fused object attribute data to the communication system module for transmission.

Abstract: A method of treating a subject can comprise administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1) depleting agent, thereby depleting CD8+ cytotoxic T and/or NK cells in vivo. A method of treating a subject can comprise administering to a subject in need thereof an effective amount of a KLRG1 depleting agent with effector killing function. A composition, for example an anti-KLRG1 antibody, can comprise a KLRG1 depleting agent. The methods and compositions can be used for various diseases in which KLRG1 is overexpressed, for example autoimmune diseases, transplant rejection, hematologic malignancies, and solid tumors.

Abstract: A method of generating and communicating lane information from a host vehicle to a vehicle-to-vehicle (V2V) network includes collecting visual data from a camera, detecting a lane within the visual data, generating a lane classification for the lane based on the visual data, assigning a confidence level to the lane classification, generating a lane distance estimate from the visual data, generating a lane model from the lane classification and the lane distance estimate, and transmitting the lane model and the confidence level to the V2V network.

Abstract: A method of treating a subject can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent, thereby disrupting KLRG1 signaling and activating CD8+ cytotoxic T and/or NK cells. A method of treating cancer can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent. The methods can treat various cancers, for example melanoma, lung cancer, pancreatic cancer, glioma, breast cancer, ovarian cancer, metastatic breast cancer, and colon cancer.

Abstract: A system for displaying an image on a display device of a motor vehicle includes a rear-view camera connected to a moveable component on the motor vehicle and a controller in communication with the rear-view camera. The controller has memory for storing control logic and a processor configured to execute the control logic. The control logic includes capturing a field of view image from the rear-view camera, determining a position of the rear-view camera, determining an image perspective relationship of the field of view image based on the position of the rear-view camera, modifying the field of view image based on the image perspective relationship to create a virtual perspective image, and displaying the virtual perspective image on the display device in the motor vehicle as the position of the rear-view camera changes between at least a first position and a second position.

Abstract: A motor vehicle alert system based on vehicle dynamics input includes a communication module positioned in a host vehicle receiving and sending vehicle data in a vehicle mobility data format. A list generator in communication with the communication module generates the vehicle data as specific vehicle identification data in a track list to distinguish a sensed vehicle and at least one other vehicle positioned proximate the host vehicle. A tracker module in communication with the list generator periodically updates the vehicle data for the sensed vehicle and the at least one other vehicle. A transient condition data device generates data identifying when a transient condition of the sensed vehicle is present. A message standard conformance module receives the data identifying the transient condition and forwards the data identifying the transient condition to the communication module for transmission to the at least one other vehicle proximate to the host vehicle.

Abstract: A fluid delivery system for dispensing fluid can include a dispenser, such as a trigger engine-type dispenser, configured to draw fluid up from a container. A nozzle assembly can include a nozzle, and a nozzle slide. The nozzle slide can be configured to slide and/or rotate relative to the shroud to provide different dispensing modes. In alternative examples, the nozzle can be configured to rotate in 30 degree increments relative to the shroud to provide the different dispensing modes or the nozzle assembly can include a nozzle extension, and the nozzle extension can be configured to rotate relative to the shroud to provide different dispensing patterns out of the nozzle. In another example a first nozzle can be configured to provide one or more dispensing modes, and a second nozzle can be configured to provide a different dispensing mode than the first nozzle. Methods of dispensing fluids and methods of assembling fluid dispensers are also disclosed.

Abstract: A fluid delivery system for dispensing fluid can include a dispenser, such as a trigger engine-type dispenser (100), configured to draw fluid up from a container. A nozzle assembly can include a nozzle (160), and a nozzle slide (112). The nozzle slide can be configured to slide and/or rotate relative to the shroud (102) to provide different dispensing modes. In alternative examples, the nozzle (160) can be configured to rotate in 30 degree increments relative to the shroud (102) to provide the different dispensing modes or the nozzle assembly can include a nozzle extension, and the nozzle extension can be configured to rotate relative to the shroud to provide different dispensing patterns out of the nozzle. In another example a first nozzle can be configured to provide one or more dispensing modes, and a second nozzle can be configured to provide a different dispensing mode than the first nozzle. Methods of dispensing fluids and methods of assembling fluid dispensers are also disclosed.

Abstract: A method for projecting information from a motor vehicle to an observer external to the motor vehicle includes receiving, by a controller, a data signal indicative of an operating state of the motor vehicle from a sensor, determining, using the controller, a projection profile based on the data signal which includes a dynamic feature and indicative of a status of the motor vehicle, and continuously projecting the projection profile onto a surface on which the motor vehicle is traveling using a dynamic projector system that animates the dynamic feature.