Patents by Inventor Evan W. ROGERS

Evan W. ROGERS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIRAL DIARYL MACROCYCLES AND USES THEREOF
    Publication number: 20210030756
    Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.
    Type: Application
    Filed: August 20, 2020
    Publication date: February 4, 2021
    Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Zhongdong HUANG
  • MACROCYCLIC COMPOUNDS FOR TREATING DISEASE
    Publication number: 20200392160
    Abstract: The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
    Type: Application
    Filed: May 5, 2020
    Publication date: December 17, 2020
    Inventors: Evan W. Rogers, Jingrong J. Cui, Dayong Zhai, Han Zhang, Jane Ung, Wei Deng, Jeffrey Whitten
  • Macrocyclic compounds for treating disease
    Patent number: 10745416
    Abstract: The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: August 18, 2020
    Assignee: Turning Point Therapeutics, Inc.
    Inventors: Evan W. Rogers, Jingrong J. Cui, Dayong Zhai, Han Zhang, Jane Ung, Wei Deng, Jeffrey Whitten
  • DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
    Publication number: 20200216465
    Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Application
    Filed: February 21, 2020
    Publication date: July 9, 2020
    Inventors: Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai
  • Macrocycle kinase inhibitors
    Patent number: 10689400
    Abstract: The present disclosure relates to certain macrocyclic kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same to treat disease.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: June 23, 2020
    Assignee: Turning Point Therapeutics, Inc.
    Inventors: Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai, Jane Ung
  • MACROCYCLIC COMPOUNDS FOR TREATING DISEASE
    Publication number: 20200190110
    Abstract: The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.
    Type: Application
    Filed: January 30, 2020
    Publication date: June 18, 2020
    Applicant: Turning Point Therapeutics, Inc.
    Inventors: Evan W. Rogers, Jingrong J. Cui, Dayong Zhai, Han Zhang, Jane Ung, Wei Deng, Jeffrey Whitten
  • MACROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20200157119
    Abstract: The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.
    Type: Application
    Filed: July 26, 2018
    Publication date: May 21, 2020
    Inventors: Jingrong Jean CUI, Evan W. ROGERS, Jane UNG, Jeffrey Whitten, Dayong Zhai, Wei DENG, Xin ZHANG, Zhongdong HUANG, Jing LIU, Han ZHANG
  • Diaryl macrocycles as modulators of protein kinases
    Patent number: 10618912
    Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: April 14, 2020
    Assignee: Turning Point Therapeutics, Inc.
    Inventors: Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai
  • CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
    Publication number: 20190284209
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 19, 2019
    Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Jane UNG
  • DIARYL MACROCYCLE POLYMORPH
    Publication number: 20190233437
    Abstract: This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Inventors: Jingrong J. Cui, Evan W. Rogers
  • Chiral diaryl macrocycles as modulators of protein kinases
    Patent number: 10316044
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives of the formula I pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 11, 2019
    Assignee: TP Therapeutics, Inc.
    Inventors: Jingrong J. Cui, Yishan Li, Evan W. Rogers, Dayong Zhai, Wei Deng, Jane Ung
  • DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
    Publication number: 20190169207
    Abstract: The present invention relates to certain diaryl inacrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Application
    Filed: November 29, 2018
    Publication date: June 6, 2019
    Inventors: Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai
  • MACROCYCLE KINASE INHIBITORS
    Publication number: 20190169208
    Abstract: The present disclosure relates to certain macrocyclic kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same to treat disease.
    Type: Application
    Filed: July 27, 2017
    Publication date: June 6, 2019
    Inventors: Jingrong Jean CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Jane UNG
  • Diaryl macrocycle polymorph
    Patent number: 10294242
    Abstract: This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: May 21, 2019
    Assignee: TP Therapeutics, Inc.
    Inventors: Jingrong J. Cui, Evan W. Rogers
  • Diaryl macrocycles as modulators of protein kinases
    Patent number: 10246466
    Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: April 2, 2019
    Assignee: TP Therapeutics, Inc.
    Inventors: Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai
  • CHIRAL DIARYL MACROCYCLES AND USES THEREOF
    Publication number: 20180325901
    Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo [4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.
    Type: Application
    Filed: July 20, 2016
    Publication date: November 15, 2018
    Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Zhongdong HUANG
  • DIARYL MACROCYCLE POLYMORPH
    Publication number: 20180194777
    Abstract: This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.
    Type: Application
    Filed: July 5, 2016
    Publication date: July 12, 2018
    Inventors: Jingrong J. CUI, Evan W. ROGERS
  • CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
    Publication number: 20180186813
    Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Application
    Filed: June 30, 2016
    Publication date: July 5, 2018
    Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Jane UNG
  • DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES
    Publication number: 20170334929
    Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Application
    Filed: May 31, 2017
    Publication date: November 23, 2017
    Inventors: Jingrong Jean CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI
  • Diaryl macrocycles as modulators of protein kinases
    Patent number: 9714258
    Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: July 25, 2017
    Assignee: TP Therapeutics, Inc.
    Inventors: Jingrong Jean Cui, Yishan Li, Evan W. Rogers, Dayong Zhai