Abstract: The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.

Abstract: The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.

Abstract: The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPS) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.

Abstract: Prepare silicon nitride-silicon carbide composite powders by carbothermal reduction of crystalline silica powder, carbon powder and, optionally, crystalline silicon nitride powder. The crystalline silicon carbide portion of the composite powders has a mean number diameter less than about 700 nanometers and contains nitrogen. The composite powders may be used to prepare sintered ceramic bodies and self-reinforced silicon nitride ceramic bodies.

Abstract: The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.

Abstract: A method for making a moisture-resistant aluminum nitride-containing powder which includes (a) coating a layer of silicate onto aluminum nitride-containing powder having aluminum nitride on at least a portion of its surface and (b) heat-treating the coated aluminum nitride-containing powder at a temperature of from 350.degree. to 1000.degree. C. for a period of time sufficient to cause the silicate to react with the surface aluminum nitride thereby forming a layer of Si--Al--O--N bonded to the surface aluminum nitride. The silicate has alkyl or alkoxyalkyl radicals attached thereto. The method yields a moisture-resistant aluminum nitride-containing powder having a layer of Si--Al--O--N reaction-bonded to the surface aluminum nitride.

Abstract: A multi-phase cemented ceramic article, method of making same, and the material thereof is disclosed which is useful for machining and forming of metals, including ferrous metals, titanium, aluminum and other metals. The article and its material preferably includes novel microstructures including platelets, a range of grain sizes which yields superior hardness and other characteristics, and a lower tungsten concentration within the binder phase than has been seen in the prior art. The preferred composition includes ultrafine WC, an ultrafine solid solution of (Ti, Ta, W)C, and a cobalt binder. Platelets are formed in-situ, eliminating the need to add them during manufacture for improving toughness.

Abstract: Silicon carbide/silicon nitride composites are prepared by carbothermal reduction of crystalline silica powder, carbon powder and optionally crsytalline silicon nitride powder. The crystalline silicon carbide portion of the composite has a mean number diameter less than about 700 nanometers and contains nitrogen.

Abstract: Prepare silicon nitride-silicon carbide composite powders by carbothermal reduction of crystalline silica powder, carbon powder and, optionally, crystalline silicon nitride powder. The crystalline silicon carbide portion of the composite powders has a mean number diameter less than about 700 nanometers and contains nitrogen. The composite powders may be used to prepare sintered ceramic bodies and self-reinforced silicon nitride ceramic bodies.

Abstract: The present invention provides a method for quantifying the presence of extracellular LBP in body fluids including blood in a subject comprising conducting an LBP immunoassay on plasma obtained from said subject.

Abstract: An apparatus and method for improving physical coordination and ability to react to moving and stationary objects is disclosed herein. A pair of voltage controlled liquid crystal lenses (14, 16) are mounted in a support frame (12) which is worn by a user in the same manner as conventional eyeglasses. The lenses (14, 16) can be electronically pulsed between an opaque state and a transparent state. Further, the lenses (14, 16) scatter background light in their opaque state rather than block the light so as to provide a generally constant level of contrast and brightness. This prevents pupil dilation changes when switching between the transparent state and the opaque state. Each lens can be made to pulse from an opaque state to a transparent state and then back again, and can be controlled independently or in synchronization. In operation, the user adjusts the control unit (18) to pulse the lenses (14, 16) at a high speed. An object is then viewed through the lenses and an appropriate response is made.

Abstract: A screen-printable thick film paste composition suitable for forming conductive patterns on a rigid substrate comprising:(a) finely divided particles of a lead-free glass composition having a softening point log (eta)=7.6 poise from 400.degree. C.-650.degree. C., a log (eta.) specific viscosity in a range from 2 at 500.degree. C. to 5 at 700.degree. C. and consisting essentially of, by weight 65-95% Bi.sub.2 O.sub.3, 2-15% SiO.sub.2, 0.1-9% B.sub.2 O.sub.3, 0-5% Al.sub.2 O.sub.3, 0-5% CaO, and 0-20% ZnO; and(b) electrically conductive particles; andall of (a) and (b) being dispersed in (c) an organic medium.

Abstract: The present invention provides a method for quantifying the presence of extracellular BPI in body fluids including blood in a subject comprising conducting a BPI immunoassay on plasma obtained from said subject.

Abstract: The present invention provides an immunoassay method for screening for gram negative sepsis in a subject, in which the concentration of extracellular BPI in a plasma sample from the subject is determined and compared with a standard concentration of BPI indicative of gram negative sepsis.

Abstract: The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) such as gelonin and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.

Abstract: The invention relates to subjecting boron carbide to a heat treatment at a temperature within a range of 1250.degree. C. to less than 1800.degree. C. prior to infiltration with a molten metal such as aluminum. This method allows control of kinetics of metal infiltration and chemical reactions, size of reaction products and connectivity of B.sub.4 C grains and results in cermets having desired mechanical properties.

Abstract: A screen-printable thick film paste composition suitable for forming conductive patterns on a rigid substrate comprising:(a) finely divided particles of a lead-free glass composition having a softening point log (eta)=7.6 poise from 400.degree. C.-650.degree. C., a log (eta.) specific viscosity in a range from 2 at 500.degree. C. to 5 at 700.degree. C. and consisting essentially of, by weight 65-95% Bi.sub.2 O.sub.3, 2-15% SiO.sub.2, 0.1-9% B.sub.2 O.sub.3, 0-5% Al.sub.2 O.sub.3, 0-5% CaO, and 0-20% ZnO; and(b) electrically conductive particles; andall of (a) and (b) being dispersed in (c) an organic medium.

Abstract: The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins and analogs thereof having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. Preferred analogs according to the present invention are analogs of Type I ribosome-inactivating proteins (1) having a cysteine available for intermolecular disulfide bonding located at an amino acid position corresponding to a position not naturally available for intermolecular disulfide bonding in the Type I ribosome-inactivating protein and corresponding to a position on the surface of ricin A-chain in its natural conformation and (2) retaining ribosome-inactivating activity of the Type I ribosome-inactivating protein. The RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents and, more specifically, as components of immunotoxins.

Abstract: Thick film paste composition for applying conductive patterns to automotive window glass comprising finely divided particles of metallic silver, glass frit having transition metal oxide, contained in the glass, all of the particulate solids being dispersed in an organic medium.

Abstract: Thick film paste composition for applying conductive patterns to automotive window glass comprising finely divided particles of metallic silver, glass frit, and selected transition metal oxides, all of the particulate solids being dispersed in an organic medium.