Abstract: An irradiation target processing system for insertion and retrieving irradiation targets into and from an instrumentation tube in a nuclear reactor core comprises, a target retrieving system, target insertion system and transport gas supply system, mounted on a movable support, wherein: the target retrieving system comprises a target exit port coupled to a target storage container and exhaust system; the target insertion system comprises a target filling device, target retention tubing with target supply junction connectable to the instrumentation tube, and a target diverter coupled to the target filling device, target retention tubing and target retrieving system; and the transport gas supply system comprises a first gas supply tubing coupled to the exit port of the target retrieving system, a second gas supply tubing coupled to a junction for supplying gas to the instrumentation tube, and a transport gas supply junction coupled to the first and second gas supply tubing.

Abstract: The invention provides for an inhibitor of the huTNFRI receptor which is a human or humanized antibody construct that monovalently recognizes huTNFRI through an antigen-binding moiety, which is characterized by specific CDR sequences, a pharmaceutical preparation thereof, method of producing the inhibitor and the medical use of the inhibitor.

Abstract: A method for harvesting activated irradiation targets (16) from an instrumentation tube system (12) of a nuclear reactor comprises the steps of: Coupling the instrumentation tube system (12) to a discharge tube (38) having an apex (50), an exit port (40) and a lock element (44) between the apex (50) and the exit port (40); Passing the activated irradiation targets (16) from the instrumentation tube system (12) into the discharge tube (38) and blocking movement of the activated irradiation targets (16) out of the discharge tube (38) by means of the lock element (44); Separating a predefined quantity (16?) of the activated irradiated targets (16) from another quantity (16?) of the targets (16) in the discharge tube (38); Coupling the exit port (40) to a storage container (42) and releasing the lock element (44) to pass the predefined quantity (16?) of the activated irradiation targets (16) under action of gravity into the storage container (42); wherein said separating step comprises passing the predefined quan

Abstract: A method of producing radionuclides from irradiation targets in a nuclear reactor uses at least one instrumentation tube system of a commercial nuclear reactor. Irradiation targets and dummy targets are inserted into an instrumentation finger and the irradiation targets are activated by exposing them to neutron flux in the nuclear reactor core to form a radionuclide. The dummy targets hold the irradiation targets at a predetermined axial position in the reactor core corresponding to a pre-calculated neutron flux density sufficient for converting the irradiation targets to the radionuclide. Separating the dummy targets from the activated irradiation targets includes exposure to a magnetic field to retain either the dummy targets or the activated irradiation targets in the instrumentation tube system and release the other one of the activated irradiation target or the dummy target from the instrumentation tube system. An apparatus adapted to the above method is also provided.

Abstract: An irradiation target processing system for insertion and retrieving irradiation targets into and from an instrumentation tube in a nuclear reactor core comprises, a target retrieving system, target insertion system and transport gas supply system, mounted on a movable support, wherein: the target retrieving system comprises a target exit port coupled to a target storage container and exhaust system; the target insertion system comprises a target filling device, target retention tubing with target supply junction connectable to the instrumentation tube, and a target diverter coupled to the target filling device, target retention tubing and target retrieving system; and the transport gas supply system comprises a first gas supply tubing coupled to the exit port of the target retrieving system, a second gas supply tubing coupled to a junction for supplying gas to the instrumentation tube, and a transport gas supply junction coupled to the first and second gas supply tubing.

Abstract: A radionuclide generation system comprises a tube system configured to permit insertion and removal of irradiation targets into an instrumentation finger of a nuclear reactor, and an irradiation target drive system configured to insert the irradiation targets into the instrumentation finger and to remove the irradiation targets from the instrumentation finger. The radionuclide generation system further comprises an instrumentation and control unit which is linked to an online core monitoring system and being configured to calculate an optimum irradiation time for the irradiation targets based on the actual state of the reactor as provided by the online core monitoring system.