Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: In an embodiment, an apparatus included in a communications system includes a transmit section including a first baseband section and a first radio frequency (RF) section, wherein the transmit section is configured to receive a calibration signal, the first RF section is configured to generate a RF calibration signal based on the calibration signal, and wherein the calibration signal comprises an orthogonal code based signal; and a receive section configured to receive the RF calibration signal over-the-air, wherein the receive section includes a second RF section and a calibration section, wherein the second RF section is configured to generate a received calibration signal based on the RF calibration signal, and wherein the calibration section is configured to determine one or more of gain, baseband delay, or RF delay compensation values, based on the inputs, to calibrate the transmit section.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: Techniques for receiving data at a physical coding sublayer (PCS) transmit structure from a media access control (MAC) sublayer are provided. A PCS transmit structure is configured to receive data from a MAC sublayer, the PCS transmit structure comprising a first FEC hardware module that performs FEC encoding, in a first clock domain, on the data to generate FEC encoded data. Further, a PCS receive structure configured to receive the FEC encoded data from the PCS transmit structure, the PCS receive structure comprising a second FEC hardware module is configured to perform FEC decoding, in the second clock domain, on the FEC encoded data to generate FEC decoded data.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Techniques for receiving data at a physical coding sublayer (PCS) transmit structure from a media access control (MAC) sublayer are provided. A PCS transmit structure is configured to receive data from a MAC sublayer, the PCS transmit structure comprising a first FEC hardware module that inserts one or more alignment markers in the data and performs FEC encoding, in a first clock domain, on the one or more alignment markers and the data to generate FEC encoded data. Further, a PCS receive structure configured to receive the FEC encoded data from the PCS transmit structure, the PCS receive structure comprising a second FEC hardware module is configured to perform FEC decoding, in the second clock domain, on the FEC encoded data to generate FEC decoded data, and remove the one or more alignment markers from the FEC decoded data.

Abstract: The invention provides a pendulum system including a pendulum connected to a connector, the system including wires connecting the pendulum to the connector, which wires are connected together in a twisted cable, the twisted cable presenting a spiral central portion generally shaped as a cone having its apex connected to the connector so as to be the portion of the spiral that is closest to the pivot point of the pendulum. The invention also provides a method of fabricating such a pendulum system.

Abstract: Techniques are provided for receiving data at a physical coding sublayer (PCS) transmit structure from a media access control (MAC) sublayer. Data is received at a PCS transmit structure from a MAC sublayer, and one or more alignment markers are inserted in the data. FEC encoding is performed, in a first clock domain, on the one or more alignment markers and the data in the PCS transmit structure to generate FEC encoded data. The FEC encoded data is transmitted from the first clock domain with a first clock cycle to a second clock domain with a second clock cycle, and the FEC encoded data is transmitted on one or more physical medium attachment (PMA) lanes to a PCS receive structure. FEC decoding is performed, in the second clock domain, on the FEC encoded data in the PCS receive structure to generate FEC decoded data.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: An underdrain assembly for filtering particulates from a fluid having an upper structure connected to a bottom plate. At least one flow control vane is positioned between the upper structure and the bottom plate for directing and managing fluid flow through the assembly. The upper structure can have first and second filtration members, the second filtration member positioned between the first filtration member and the bottom plate. The second filtration member can have a shape that restricts fluid flow within the underdrain. The underdrain can have air and water inlets. The water inlet can have an end with a plate covering an upper portion thereof. The end can also include an opening having an angular cut forming an angle with respect to a longitudinal axis of the water inlet. Thus arranged, air is prevented from migrating out the water line. A resilient mounting arrangement for the underdrain is also disclosed.

Abstract: The invention provides a pendulum system including a pendulum connected to a connector, the system including wires connecting the pendulum to the connector, which wires are connected together in a twisted cable, the twisted cable presenting a spiral central portion generally shaped as a cone having its apex connected to the connector so as to be the portion of the spiral that is closest to the pivot point of the pendulum. The invention also provides a method of fabricating such a pendulum system.

Abstract: Techniques for receiving data at a physical coding sublayer (PCS) transmit structure from a media access control (MAC) sublayer are provided. A PCS transmit structure is configured to receive data from a MAC sublayer, the PCS transmit structure comprising a first FEC hardware module that inserts one or more alignment markers in the data and performs FEC encoding, in a first clock domain, on the one or more alignment markers and the data to generate FEC encoded data. Further, a PCS receive structure configured to receive the FEC encoded data from the PCS transmit structure, the PCS receive structure comprising a second FEC hardware module is configured to perform FEC decoding, in the second clock domain, on the FEC encoded data to generate FEC decoded data, and remove the one or more alignment markers from the FEC decoded data.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: The invention relates to fused piperidine amides useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: Techniques are provided for receiving data at a physical coding sublayer (PCS) transmit structure from a media access control (MAC) sublayer. Data is received at a PCS transmit structure from a MAC sublayer, and one or more alignment markers are inserted in the data. FEC encoding is performed, in a first clock domain, on the one or more alignment markers and the data in the PCS transmit structure to generate FEC encoded data. The FEC encoded data is transmitted from the first clock domain with a first clock cycle to a second clock domain with a second clock cycle, and the FEC encoded data is transmitted on one or more physical medium attachment (PMA) lanes to a PCS receive structure. FEC decoding is performed, in the second clock domain, on the FEC encoded data in the PCS receive structure to generate FEC decoded data.

Abstract: Method and apparatus for receiving data at a physical coding sublayer (PCS) transmit structure from a media access control (MAC) sublayer. The method includes performing a first forward error-correcting (FEC) sub-function on the data in the PCS transmit structure. The method further includes transmitting the data on one or more physical medium attachment (PMA) lanes to a PCS receive structure. The method also includes performing a second FEC sub-function on the data in the PCS receive structure.

Abstract: Method and apparatus for receiving data at a physical coding sublayer (PCS) transmit structure from a media access control (MAC) sublayer. The method includes performing a first forward error-correcting (FEC) sub-function on the data in the PCS transmit structure. The method further includes transmitting the data on one or more physical medium attachment (PMA) lanes to a PCS receive structure. The method also includes performing a second FEC sub-function on the data in the PCS receive structure.