Abstract: An electronic device includes a 2D material layer having a bandgap. The 2D material layer includes two multilayer 2D material regions and a channel region therebetween. A first electrode electrically contacts one of the multilayer 2D material regions, and a second electrode electrically contacts the other of the multilayer 2D material regions.

Abstract: Efficient exploration of natural language conversations associated with dialogue policy learning may be performed using probabilistic distributions. Exploration may comprise identifying key terms associated with the received natural language input utilizing the structured representation. Identifying key terms may include converting raw text of the received natural language input into a structured representation. Exploration may also comprise mapping at least one of the key terms to an action to be performed by the computer system in response to receiving natural language input associated with the at least one key term. Mapping may then be performed using a probabilistic distribution. The action may then be performed by the computer system. A replay buffer may also be utilized by the computer system to track what has occurred in previous conversations. The replay buffer may then be pre-filled with one or more successful dialogues to jumpstart exploration.

Abstract: Storage system and application intercommunication is provided. A first kernel-mode module determines a first event corresponding to an operational parameter of a first node based, at least in part, on a shared namespace accessible by the first kernel-mode module and a second kernel-mode module. An interrupt is issued based on the first event from the first kernel-mode module to the second kernel-mode module via an interface. The second kernel-mode module issues a second event to a second node, wherein the second event corresponds to the object of the shared namespace.

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract: Storage system and application intercommunication is provided. A first kernel-mode module determines a first event corresponding to an operational parameter of a first node based, at least in part, on a shared namespace accessible by the first kernel-mode module and a second kernel-mode module. An interrupt is issued based on the first event from the first kernel-mode module to the second kernel-mode module via an interface. The second kernel-mode module issues a second event to a second node, wherein the second event corresponds to the object of the shared namespace.

Abstract: Determining a preferred interface for write access to a data storage system having multiple interfaces. Interface preference is determined at the data-stripe level. Write requests are routed to the preferred interface.

Abstract: Described herein are systems, methods, and techniques by which a processing unit can build an end-to-end dialogue agent model for end-to-end learning of dialogue agents for information access and apply the end-to-end dialogue agent model with soft attention over knowledge base entries to make the dialogue system differentiable. In various examples the processing unit can apply the end-to-end dialogue agent model to a source of input, fill slots for output from the knowledge base entries, induce a posterior distribution over the entities in a knowledge base or induce a posterior distribution of a target of the requesting user over entities from a knowledge base, develop an end-to-end differentiable model of a dialogue agent, use supervised and/or imitation learning to initialize network parameters, calculate a modified version of an episodic algorithm, e.g., the REINFORCE algorithm, for training an end-to-end differentiable model based on user feedback.

Abstract: Efficient exploration of natural language conversations associated with dialogue policy learning may be performed using probabilistic distributions. Exploration may comprise identifying key terms associated with the received natural language input utilizing the structured representation. Identifying key terms may include converting raw text of the received natural language input into a structured representation. Exploration may also comprise mapping at least one of the key terms to an action to be performed by the computer system in response to receiving natural language input associated with the at least one key term. Mapping may then be performed using a probabilistic distribution. The action may then be performed by the computer system. A replay buffer may also be utilized by the computer system to track what has occurred in previous conversations. The replay buffer may then be pre-filled with one or more successful dialogues to jumpstart exploration.

Abstract: Storage system and application intercommunication is provided. A first kernel-mode module determines a first event corresponding to an operational parameter of a first node based, at least in part, on a shared namespace accessible by the first kernel-mode module and a second kernel-mode module. An interrupt is issued based on the first event from the first kernel-mode module to the second kernel-mode module via an interface. The second kernel-mode module issues a second event to a second node, wherein the second event corresponds to the object of the shared namespace.

Abstract: Determining a preferred interface for write access to a data storage system having multiple interfaces. Interface preference is determined at the data-stripe level. Write requests are routed to the preferred interface.

Abstract: Determining a preferred interface for write access to a data storage system having multiple interfaces. Interface preference is determined at the data-stripe level. Write requests are routed to the preferred interface.

Abstract: Storage system and application intercommunication is provided. A first kernel-mode module determines a first event corresponding to an operational parameter of a first node based, at least in part, on a shared namespace accessible by the first kernel-mode module and a second kernel-mode module. An interrupt is issued based on the first event from the first kernel-mode module to the second kernel-mode module via an interface. The second kernel-mode module issues a second event to a second node, wherein the second event corresponds to the object of the shared namespace.

Abstract: An electronic device includes a 2D material layer having a bandgap. The 2D material layer includes two multilayer 2D material regions and a channel region therebetween. A first electrode electrically contacts one of the multilayer 2D material regions, and a second electrode electrically contacts the other of the multilayer 2D material regions.

Abstract: A flat panel imaging system for imaging cells provided on a cell medium is disclosed. The system includes a housing having a base portion and a lid that collectively form a closed environment to exclude external sources of light, and a flat panel detector encased in the base portion and having an array of pixels each including a photodiode and transistor. The system also includes a first light source that illuminates cells on the cell medium to excite at least a portion of the cells and cause those cells to generate photons that are captured by the array of pixels and a second light source to illuminate cells on the cell medium with a light different from the light from the first light source and that provides for a capturing of photons representative of photons transmitted through the cells on the cell medium.

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract: A flat panel imaging system for imaging cells provided on a cell medium is disclosed. The system includes a housing having a base portion and a lid that collectively form a closed environment to exclude external sources of light, and a flat panel detector encased in the base portion and having an array of pixels each including a photodiode and transistor. The system also includes a first light source that illuminates cells on the cell medium to excite at least a portion of the cells and cause those cells to generate photons that are captured by the array of pixels and a second light source to illuminate cells on the cell medium with a light different from the light from the first light source and that provides for a capturing of photons representative of photons transmitted through the cells on the cell medium.

Abstract: Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.

Abstract: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.

Abstract: Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.

Abstract: The invention relates generally to a process of analyzing and visualizing the expression of biomarkers in individual cells wherein the cells are examined to develop patterns of expression by using a grouping algorithm, and a system to perform and display the analysis.