Patents by Inventor Faisal Ahmed
Faisal Ahmed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8318456Abstract: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.Type: GrantFiled: May 23, 2012Date of Patent: November 27, 2012Assignee: General Electric CompanyInventors: Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20120278082Abstract: The invention is directed to combining web browser and audio player functionality for the organization and consumption of web documents. Specifically, the invention identifies a set of web documents via a web browser, extracts content from the web documents, and adds the set of web documents to a playlist. In this way, users can build a playlist of web documents and utilize the functionality and convenience of an audio player and listen to the content of the playlist.Type: ApplicationFiled: April 27, 2012Publication date: November 1, 2012Applicant: CHARMTECH LABS LLCInventors: Yevgen Borodin, Alexander Dimitriyadi, Yury Puzis, Faisal Ahmed, Valentyn Melnyk
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Publication number: 20120253006Abstract: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.Type: ApplicationFiled: May 23, 2012Publication date: October 4, 2012Applicant: General Electric CompanyInventors: Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20120165650Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.Type: ApplicationFiled: December 22, 2010Publication date: June 28, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Faisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Eriksson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Patent number: 8198043Abstract: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders, and host cells transformed with vectors containing the nucleic acid sequences encoding for the two-helix binders. Also provided are methods of using the two helix binders.Type: GrantFiled: December 8, 2006Date of Patent: June 12, 2012Assignee: General Electric CompanyInventors: Faisal Ahmed Syud, Jack Mathew Webster
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Patent number: 8124725Abstract: Provided herein are PDGF-R? imaging agents that are polypeptides labeled with a signal generator (e.g., paramagnetic label, a radionuclide, or a fluorophore), wherein the imaging agents bind specifically to PDGFR-?. Also provided are in vivo imaging methods using the imaging agents.Type: GrantFiled: December 17, 2008Date of Patent: February 28, 2012Assignee: General Electric CompanyInventors: Michael Ernest Marino, Faisal Ahmed Syud, Paul Schaffer, Brian Duh-Lan Lee, Rong Zhang, Malin Lindborg, Elin Gunneriusson, Christopher Lendel
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Patent number: 8071718Abstract: Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.Type: GrantFiled: December 20, 2007Date of Patent: December 6, 2011Assignee: General Electric CompanyInventors: Omayra Liz Padilla De Jesus, Ernest William Kovacs, Matthias Eberhard Glaser, Erik Arstad, Faisal Ahmed Syud
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Patent number: 7989216Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of different natural amino acid mutations in the polypeptide are provided here. Also provided are methods of using the two-helix binders.Type: GrantFiled: December 18, 2008Date of Patent: August 2, 2011Assignee: General Electric CompanyInventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Patent number: 7981691Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.Type: GrantFiled: December 18, 2008Date of Patent: July 19, 2011Assignee: General Electric CompanyInventors: Joshua Kendall Hoerner, Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Patent number: 7977118Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an un-natural amino acid in the polypeptide is provided here. Also provided are methods of using the two-helix binders.Type: GrantFiled: December 18, 2008Date of Patent: July 12, 2011Assignee: General Electric CompanyInventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20110160430Abstract: Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.Type: ApplicationFiled: February 22, 2011Publication date: June 30, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Omayra Padilla de Jesus, Faisal Ahmed Syud, Rong Zhang, Ernest William Kovacs
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Patent number: 7937574Abstract: In an embodiment, a microcode unit for a processor is contemplated. The microcode unit comprises a microcode memory storing a plurality of microcode routines executable by the processor, wherein each microcode routine comprises two or more microcode operations. Coupled to the microcode memory, the sequence control unit is configured to control reading microcode operations from the microcode memory to be issued for execution by the processor. The sequence control unit is configured to stall issuance of microcode operations forming a body of a loop in a first routine of the plurality of microcode routines until a loop counter value that indicates a number of iterations of the loop is received by the sequence control unit.Type: GrantFiled: July 17, 2007Date of Patent: May 3, 2011Assignee: Advanced Micro Devices, Inc.Inventors: Michael T. Clark, Jelena Ilic, Syed Faisal Ahmed, Michael T. DiBrino
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Publication number: 20110091091Abstract: The invention relates generally to a process of analyzing and visualizing the expression of biomarkers in individual cells wherein the cells are examined to develop patterns of expression by using a grouping algorithm, and a system to perform and display the analysisType: ApplicationFiled: July 23, 2010Publication date: April 21, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Brion Daryl Sarachan, Faisal Ahmed Syud, Michael John Gerdes, Megan Pearl Rothney, Brian Michael Davis
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Publication number: 20110070596Abstract: Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.Type: ApplicationFiled: February 15, 2010Publication date: March 24, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Nichole Lea Wood, Mohan Mark Amaratunga, Hans Grade, Faisal Ahmed Syud, Anup Sood, Reginald Donovan Smith, Ayse Betul Dinc, Amy Casey Williams, Anthony John Murray, Gregory Daryll Goddard
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Patent number: 7902332Abstract: Methods for introducing fluorine atom onto a polypeptide are provided. Also provided are linkers, bioconjugates, and bifunctional compound agents made using the methods, linkers, and bioconjugates. The methods comprise: (i) providing a linker comprising a thiol-reactive terminus and an aldehyde-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a polypeptide comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the aldehyde-reactive terminus of the linker with a fluorine-substituted aldehyde.Type: GrantFiled: November 30, 2006Date of Patent: March 8, 2011Assignee: General Electric CompanyInventors: Omayra Padilla De Jesus, Faisal Ahmed Syud, Rong Zhang, Ernest William Kovacs
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Publication number: 20100272641Abstract: Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.Type: ApplicationFiled: April 27, 2009Publication date: October 28, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: JACK MATHEW WEBSTER, FAISAL AHMED SYUD, BRIAN DUH-LAN LEE, PAUL SCHAFFER, RONG ZHANG, JENNIFER LYNNE HUNTINGTON, KANDE KANKANAMALAGE DAYARATHNA AMARASINGHE
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Patent number: 7772363Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.Type: GrantFiled: December 18, 2008Date of Patent: August 10, 2010Assignee: General Electric CompanyInventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20100047923Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of different natural amino acid mutations in the polypeptide are provided here. Also provided are methods of using the two-helix binders.Type: ApplicationFiled: December 18, 2008Publication date: February 25, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20100041073Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of a covalent bridge between two modified amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.Type: ApplicationFiled: December 18, 2008Publication date: February 18, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Joshua Kendall Hoerner, Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster
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Publication number: 20100035361Abstract: An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.Type: ApplicationFiled: December 18, 2008Publication date: February 11, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Rong Zhang, Faisal Ahmed Syud, Jack Mathew Webster