Abstract: A system for the amelioration of a recess (56) is disclosed, particularly of a recess in a porous, perforate material having cavities freed by the recess, said system comprising an element (2) for generating or coupling in mechanical energy, and a cylindrical collar (4, 40) having a central recess (44,45) for receiving a guide pin (8), wherein the guide pin (8), having a cannulation (35), is provided to be inserted substantially as far as the bottom of the recess (56) under positioning using a wire (52) before mechanical energy is applied, wherein the guide pin (8), in the area of the end thereof directed toward the bottom of the recess (56), is surrounded by an amelioration sleeve (7), wherein the external cylindrical jacket surface of the amelioration sleeve (7) has substantially the same external diameter as the collar (4, 40), and wherein the guide pin (8) is received movably in the central recess (44,45) such that, when mechanical energy is applied, the collar (4,40) can be moved relative to the guide pi

Abstract: A system for the amelioration of a recess (56) in a porous material, said system comprising an element (2) for coupling in mechanical energy, and a cylindrical collar (4, 40) having a central recess (44,45) for a guide pin (8), wherein the pin (8), having a cannulation (35), is provided to be inserted as far as the bottom of the recess (56) using a wire (52), wherein the pin (8) is surrounded by an amelioration sleeve (7), wherein the external cylindrical jacket surface of the sleeve (7) has substantially the same external diameter as the collar (4, 40), and wherein the pin (8) is received movably in the central recess (44,45) such that, when mechanical energy is applied, the collar (4,40) can be moved relative to the guide pin (8) in the direction toward the bottom of the recess (8) while liquefying and displacing the material of the sleeve (7).

Abstract: A system for the amelioration of a recess (56) in a porous material, said system comprising an element (2) for coupling in mechanical energy, and a cylindrical collar (4, 40) having a central recess (44,45) for a guide pin (8), wherein the pin (8), having a cannulation (35), is provided to be inserted as far as the bottom of the recess (56) using a wire (52), wherein the pin (8) is surrounded by an amelioration sleeve (7), wherein the external cylindrical jacket surface of the sleeve (7) has substantially the same external diameter as the collar (4, 40), and wherein the pin (8) is received movably in the central recess (44,45) such that, when mechanical energy is applied, the collar (4,40) can be moved relative to the guide pin (8) in the direction toward the bottom of the recess (8) while liquefying and displacing the material of the sleeve (7).

Abstract: A package (1) for a dental implant (2) comprising a housing (5) with a compartment (51), closable liquid-tight by cover (4) and for receiving a first section (2?) of the implant (2), and an area (19) for a second section (3) of the implant (2). The area is separated rated from the compartment (51) by housing wall (8). A passage (35) in wall (8) connects the compartment (51) and area (19). The housing wall (8) comprises a removal slot (9, 36) for removal of the implant when the cover (4) is open without separating the sections (2, 3). The package (1) has a fluid cartridge (12) and an associated release element (18) and the fluid cartridge (12) can be opened by way of the release element (18) when the cover (4) is closed such that fluid located in the fluid cartridge (12) can flow out into the compartment (51).

Abstract: The document proposes a diagnostic chewing gum for identifying the presence of inflammatory tissues in the mouth, in particular in or adjacent to the mandible, the maxilla, an implant or the teeth of a user, comprising a base material or particles (3) embedded and/or attached to the base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user; wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4), e.g. a proteolytic enzyme, which is released by inflammatory tissue in response to bacterial mediators.

Abstract: Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles (3) embedded and/or attached to the base material and an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.

Abstract: A package (1) for a dental implant (2) comprising a housing (5) with a compartment (51), closable liquid-tight by cover (4) and for receiving a first section (2?) of the implant (2), and an area (19) for a second section (3) of the implant (2). The area is separated rated from the compartment (51) by housing wall (8). A passage (35) in wall (8) connects the compartment (51) and area (19). The housing wall (8) comprises a removal slot (9, 36) for removal of the implant when the cover (4) is open without separating the sections (2, 3). The package (1) has a fluid cartridge (12) and an associated release element (18) and the fluid cartridge (12) can be opened by way of the release element (18) when the cover (4) is closed such that fluid located in the fluid cartridge (12) can flow out into the compartment (51).

Abstract: The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.

Abstract: The invention relates to a device (1) for the amelioration of a recess (8), e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereat facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: Package (1) for an implant (2), in particular for a dental implant, comprising a housing (5) with a compartment (51) that can be closed by way of a pivotable and/or slidable cover (4) so as to be essentially liquid-tight, said compartment being intended for a first section (2?) of the implant (2), and an area (19) for a second section (3) of the implant (2), said area being separated rated from the compartment (51) by way of a housing wall (8), wherein a passage (35) connecting the compartment (51) and said area (19) is provided in the housing wall (8) for a transition section (3?) between the first section (2?) and the second section (3) of the implant (2), and wherein the housing wall (8) comprises a removal slot (9, 36) for removal of the implant when the cover (4) is open without separating the sections (2, 3).

Abstract: The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterized in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.

Abstract: The document proposes a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, comprising a base material or particles (3) embedded and/or attached to said base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to said base material and/or said particles, for the generation of a change in the chewing gum directly detectable by the user; wherein said pathogen is selected from the group consisting of virus, bacterium, protozoa, prion, fungus or a combination thereof; and wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by said pathogens, or, in case of a virus or prion, by the cellular structure hosting it.

Abstract: The document proposes a diagnostic chewing gum for identifying the presence of inflammatory tissues in the mouth, in particular in or adjacent to the mandible, the maxilla, an implant or the teeth of a user, comprising a base material or particles (3) embedded and/or attached to said base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to said base material and/or said particles, for the generation of a change in the chewing gum directly detectable by the user; wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4), e.g. a proteolytic enzyme, which is released by inflammatory tissue in response to bacterial mediators.

Abstract: A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

Abstract: The invention relates to a device (1) for the amelioration of a recess (8) e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereat facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

Abstract: The invention relates to a device (1) for the amelioration of a recess (8), e.g. a recess in a (human) bone (7). The device comprises an element (2) for producing or coupling mechanical energy, and a cylindrical collar (4) comprising a cylindrical lateral surface having an outside diameter and having a central recess (26) for accommodating a guide pin (3). The guide pin (3) is provided to be inserted substantially down to the base of the recess (8) before applying oscillations, and in the region of the end thereof facing the base of the recess it is surrounded by an amelioration sleeve (6) made from a material that can be liquefied by way of ultrasonic oscillations.

Abstract: The invention relates to a ceramic implant, especially a dental implant, comprising a structured or porous surface for at least partially inserting into a bone. An especially advantageous surface is obtained when it is at least partially modified by a salt melt. These excellent osteointegration properties can be obtained by a method whereby the surface is modified in a salt melt at least in the regions exposed to the bones and/or soft tissue, optionally following a previous modification of the surface whereby material has been removed.

Abstract: The invention discloses a novel implant provided with a macroporous surface on the top surface, and a method for the production of such a metallic and/or ceramic implant having a textured, particularly porous, surface for the at least partial insertion in hard tissue, such as in a bone, and/or into soft tissue. The implant is produced as a green compact, at least in sections, using a cold isostatic pressing, casting, and/or injecting (CIM, MIM) with subsequent sintering to obtain an implant, and is particularly characterized in that the surface is modified and/or prepared before sintering such that a macroporous surface is present after sintering without requiring any finishing.

Abstract: The disclosed methods, uses and articles are in the field of orthopedic and dental implants. In particular, the disclosure relates to compositions and methods for improving the osseointegration of such implants.