Abstract: A process for producing a ceramic implant which is structured on the surface at least in the region in contact with bone and/or tissue is described. The process is characterized in that the ceramic implant after shaping and sintering is, in the region to be structured, I. reduced to the corresponding metal on the surface; II. the essentially metallic surface is subsequently subjected to a structuring surface treatment; III. the structure surface is oxidized. Furthermore, implants which have been provided with a topological structure on the surface by means of this process are described.

Abstract: What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.

Abstract: A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

Abstract: A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

Abstract: A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

Abstract: The invention describes a device (1) for the amelioration of a recess (8), particularly a recess in a porous material or (human) bone (7).

Abstract: Package (1) for an implant (2), in particular for a dental implant, comprising a housing (5) with a compartment (51) that can be closed by way of a pivotable and/or slidable cover (4) so as to be essentially liquid-tight, said compartment being intended for a first section (2?) of the implant (2), and an area (19) for a second section (3) of the implant (2), said area being separated rated from the compartment (51) by way of a housing wall (8), wherein a passage (35) connecting the compartment (51) and said area (19) is provided in the housing wall (8) for a transition section (3?) between the first section (2?) and the second section (3) of the implant (2), and wherein the housing wall (8) comprises a removal slot (9, 36) for removal of the implant when the cover (4) is open without separating the sections (2, 3).

Abstract: What is described is an implant that comprises a coating, at least in areas, in the implanted state in the surface areas that are at least directly in contact with skin and/or soft tissue. The implant is preferably characterized in that the coating comprises both a statin, such as simvastatin, in the hydrolyzed or unhydrolyzed form, or pharmaceutically compatible salts thereof, as well as at least one other component selected from the group consisting of branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl, alkenyl, alkylaryl, aryl, cycloalkyl, alkylcycloalkyl, alkylcycloaryl amines or mixtures thereof and/or at least one water-soluble ionic polymer component. A method for production such an implant is also described as well as a composition that can be used in such a method.

Abstract: A process for producing a ceramic implant which is structured on the surface at least in the region in contact with bone and/or tissue is described. The process is characterized in that the ceramic implant after shaping and sintering is, in the region to be structured, I. reduced to the corresponding metal on the surface; II. the essentially metallic surface is subsequently subjected to a structuring surface treatment; III. the structure surface is oxidized. Furthermore, implants which have been provided with a topological structure on the surface by means of this process are described.

Abstract: A metal implant, in particular a dental implant, with a hydrophilic surface for at least partial insertion into a bone, and a method for the production of said implant are described. A particularly advantageous hydrophilic surface for improved osteointegration properties is made available if it is briefly treated, at least in some areas, in a weakly alkaline solution. These excellent osteointegration properties can be achieved in a method in which, optionally after a preceding mechanical surface modification by material removal and/or chemical surface modification, at least the areas exposed of this surface exposed to bone and/or soft tissue are chemically modified in an alkaline solution.

Abstract: The invention discloses a novel implant provided with a macroporous surface on the top surface, and a method for the production of such a metallic and/or ceramic implant having a textured, particularly porous, surface for the at least partial insertion in hard tissue, such as in a bone, and/or into soft tissue. The implant is produced as a green compact, at least in sections, using a cold isostatic pressing, casting, and/or injecting (CIM, MIM) with subsequent sintering to obtain an implant, and is particularly characterized in that the surface is modified and/or prepared before sintering such that a macroporous surface is present after sintering without requiring any finishing.

Abstract: The invention relates to a dental implant, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.

Abstract: The invention relates to an implant, e.g. a stent, bone replacement material, a prosthesis, a scaffold or similar, which comprises a coating at least in those surface areas that come into contact with hard and/or soft tissue when implanted. To ensure that the active ingredient contained in the coating (bisphosphonate) is released into the surrounding tissue or can act in the latter in a controlled manner at the correct speed, the coating is characterised in that it contains bisphosphonate, the respective pharmaceutically compatible salts or esters of the latter, in addition to at least one amphiphilic component, selected from the group containing branched or linear, substituted or unsubstituted, saturated or partially unsaturated C10-C30 alkyl-, alkenyl, alkylaryl-, aryl-, cycloalkyl-, alkylcycloalkyl-, alkylcycloaryl-carboxylates, -phosphates or -sulfates or mixtures thereof and/or a water-soluble ionic polymer component.

Abstract: The invention relates to a ceramic implant, especially a dental implant, comprising a structured or porous surface for at least partially inserting into a bone. An especially advantageous surface is obtained when it is at least partially modified by a salt melt. These excellent osteointegration properties can be obtained by a method whereby the surface is modified in a salt melt at least in the regions exposed to the bones and/or soft tissue, optionally following a previous modification of the surface whereby material has been removed.

Abstract: A bioactive surface layer that is particularly suited for medical implants and prostheses. A variable portion of the 0.1 to 50.0 ?m thick, porous surface layer includes calcium phosphate phases. The surface layer contains amorphous or nanocrystalline calcium phosphates and the pore density on the surface of the surface layer ranges from 104 to 108 pores/mm2. The ratio of Ca/P over the entire surface layer ranges from 0.5 to 2.0. The surface layer has a high solubility so that it can act as a contributor of calcium phosphate for the formation of bone.

Abstract: A process for surface-enhanced Raman spectrometric analysis of substances comprises the steps of providing substances to be analyzed, providing a carrier-layer with a multiplicity of nanobodies for receiving the substances to be analyzed, the multiplicity of nanobodies formed on at least one side of the carrier layer, whereby each nanobody has a rod-like stem area lying on the carrier layer and at least two branch elements formed on the stem area, and the density of the branch elements is a least 108/cm2; locating the substances on the carrier layer; and irradiating the substances to provide a Raman scatter.