Abstract: The present disclosure relates generally to method of preparing aptamers, aptamers, and uses thereof.

Abstract: A heart CT image processing method and apparatus and a non-transitory computer readable storage medium are provided in this application. The heart CT image processing method comprises reconstructing a heart CT image of a detected object based on projection data of a heart region of the detected object; processing voxel points having voxel values within a first threshold range in the heart CT image and obtaining a first image, wherein the first threshold range is defined by a CT value of a metal object; performing lung region segmentation on the first image to obtain a second image; performing initial heart region segmentation on the second image to obtain a third image; and performing rib removal on the third image to obtain a heart image.

Abstract: A range finder includes a laser transmitter, a laser receiver, a large-aperture objective lens unit, an image sensing device, a display device and a microphone. The laser transmitter is configured to emit a laser beam to a measured object. The laser receiver is configured to receive a reflected laser beam reflected by the measured object. The objective lens unit is configured to allow visible light reflected by the measured object to pass therethrough, includes an objective lens and a focusing lens and has a length defined by the objective lens and the focusing lens. The image sensing device is configured to receive the visible light passing through the objective lens and generate an image signal. The length is constant when the objective lens unit is moved with respect to the image sensing device for focusing operation.

Abstract: Method and server are disclosed for positioning user equipment (UE). According to an embodiment, positioning-related information is collected for each of a plurality of UEs from at least one network node for at least a first duration of time. For each UE, matching positioning-related information is determined that is matched with the UE's registration address related information, wherein the plurality of UEs' registration addresses are obtained from a network provider. A reference database is created which contains, for each UE, a reference point comprising the UE's identification (ID), registration address related information and matching positioning-related information. In response to a positioning request, a UE's current positioning-related information is acquired from a network node. The UE is positioned based on its current positioning-related information and the reference database.

Abstract: A payment processing system continuously processes transactions. Upon arrival, in real-time, a transaction is parsed and each entity is used to retrieve other previous transactions associated with that entity in order to build a link analysis web. Iteratively, each entity in the retrieved transactions is used to retrieve other associated transactions, etc. Before retrieval of associated transactions, each entity is checked whether it appears in a bypass table. If so, that entity is not used to retrieve transactions. Once built, transactions and entities within the link analysis web are analyzed to determine whether the current transaction is fraudulent. Off-line or online, risk metrics such as address mismatch rate, bank decline rate, ticket decline rate and new payment device rate, along with the proportion of a linked entity is used to determine whether that linked entity is erroneous and should be placed into the bypass table and excluded from the web.

Abstract: A pharmaceutical combination comprising an ALK inhibitor, in free form or a pharmaceutically acceptable salt thereof, and a SHP2 inhibitor, in free form or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: Described herein are immunogenic compositions for preventing infection with Middle East respiratory syndrome coronavirus (MERS-CoV) wherein the immunogenic compositions comprise at least a portion of the MERS-CoV S protein and an immunopotentiator.

Abstract: A collapsible structure for interlinking front and rear wheels of a golf cart is disclosed herein. It comprises an upper frame having two shaft racks, two handles and a supporting rod; a lower frame pivotally connected to the supporting rod and having a first assembling seat pivotally connected to the two shaft racks, two sliding sleeves, each having an upper connecting rod, a rear wheel joint rod and a front wheel push rod, and a second assembling seat having an oblique guide slot and a guiding tooth row in the oblique guide slot for connection to the front wheel push rod; two rear wheel assemblies connected to the two rear wheel joint rods; and a front wheel assembly comprising a guide rod having an annular teeth for engaging with the guiding tooth row in the oblique guide slot.

Abstract: The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one or (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one, and a cyclin dependent kinase 4/6 (CDK4/6) inhibitor 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide. In addition, the disclosure relates to a pharmaceutical combination product. The disclosure also relates to corresponding pharmaceutical formulations, uses and treatment methods comprising said mdm2/4 inhibitor or a cyclin dependent kinase 4/6 (CDK4/6) inhibitor.

Abstract: A handheld flashlight is provided. The handheld flashlight includes a hollow cylinder having a first end and a second end, wherein the hollow cylinder is configured to receive therein and mount thereon a rechargeable battery; a lamp head, connected the first end of the hollow cylinder and comprising a light source; a window breaker, configured to break windows for emergency vehicular escape; a charging-discharging port, selectively connected to an external power source or an external load; a connection port, selectively connected to positive and negative terminals of a vehicle battery through external cables; and a management circuit, selectively applying power from the battery to the light source, the charging-discharging port, and the connection, and selectively charging the battery from the external power source through the charging-discharging port; wherein the handheld flashlight is of such compact size and low weight as to be suitable for single-handed portable operation by a user.

Abstract: A pharmaceutical combination comprising (a) an ALK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) at least one HDMA-2/p53 receptor inhibitor or a pharmaceutically acceptable salt, or at least one BRaf inhibitor or a pharmaceutically acceptable salt, and optionally a pharmaceutically acceptable carrier, for simultaneous, separate or sequential administration; the uses of such combination in the treatment of cancer; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: A radiotherapy center includes a treatment room and a radiation machine located in the treatment room. The treatment room is constructed with materials comprising a plurality of prefabricated, modular radiation shielding blocks. The radiotherapy center may further include a plurality of functional rooms adjacent to the treatment room. The plurality of functional rooms may be constructed from a plurality of prefabricated modules. The plurality of functional rooms may be arranged in a quadrangle configuration, surrounding a central atrium.

Abstract: The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one or (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one, and a cyclin dependent kinase 4/6 (CDK4/6) inhibitor 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide. In addition, the disclosure relates to a pharmaceutical combination product. The disclosure also relates to corresponding pharmaceutical formulations, uses and treatment methods comprising said mdm2/4 inhibitor or a cyclin dependent kinase 4/6 (CDK4/6) inhibitor.

Abstract: A clamp meter includes a meter body and a clamp jaw assembly mounted to the meter body. The clamp jaw assembly includes a first clamp jaw and a second clamp jaw that are movable in relation to each other between a closed position and an open position. In the closed position, distal ends of the first and second clamp jaws meet to define an enclosed area between the first and second clamp jaws, and in the open position, the distal ends of the first and second clamp jaws separate from each other to define a gap allowing a wire under test to pass therethrough. The clamp meter further includes a locking slider positioned within a slot inside the meter body. A switch assembly moves the locking slider longitudinally within the slot between locked and unlocked positions. In the locked position, the locking slider blocks the first clamp jaw from movement.

Abstract: A portable measurement device includes an elongated body, a stationary portion fixedly mounted to a distal end, and a movable jaw movably mounted to the distal end and movable between a closed position and an open position. In the closed position, the movable jaw and the stationary portion form a closed loop with an inner diameter of less than or equal to 10 mm. Alternatively, at least one of the movable jaw and the stationary portion has a cross-sectional diameter of less than or equal to 5 mm. In the open position, the movable jaw and the stationary portion define a gap allowing a wire under test to pass therethrough into the loop. A switch drives the movable jaw between the closed and open positions. A measurement circuit electrically coupled to the stationary portion and the movable jaw to receive and measure a sensing current generated by the closed loop.

Abstract: The invention provides a binding-induced DNA nanomachine that can be activated by proteins and nucleic acids. This new type of nanomachine hamesses specific target binding to trigger assembly of separate DNA components that are otherwise unable to spontaneously assemble. Three-dimensional DNA tracks of high density are constructed on gold nanoparticles functionalized with hundreds of single-stranded oligonucleotides and tens of an affinity ligand. A DNA swing arm, free in solution, can be linked to a second affinity ligand. Binding of a target molecule to the two ligands brings the swing arm to AuNP and initiates autonomous, stepwise movement of the swing arm around the AuNP surface. The movement of the swing arm generates hundreds of oligonucleotides in response to a single binding event. The new nanomachines have several unique and advantageous features over DNA nanomachines that rely on DNA self-assembly.

Abstract: A method for forming a semiconductor device is provided. The method includes forming a dielectric layer over a semiconductor substrate and forming a contact plug in the dielectric layer. The method also includes partially removing the contact plug to form a recess over the contact plug. The method further includes forming a capacitor element in the recess.

Abstract: A range finder includes a laser transmitter, a laser receiver, a large-aperture objective lens unit, an image sensing device, a display device and a microphone. The laser transmitter is configured to emit a laser beam to a measured object. The laser receiver is configured to receive a reflected laser beam reflected by the measured object. The objective lens unit is configured to allow visible light reflected by the measured object to pass therethrough, includes an objective lens and a focusing lens and has a length defined by the objective lens and the focusing lens. The image sensing device is configured to receive the visible light passing through the objective lens and generate an image signal. The length is constant when the objective lens unit is moved with respect to the image sensing device for focusing operation.

Abstract: A clamp meter includes a meter body and a clamp jaw assembly mounted to the meter body. The clamp jaw assembly includes a first clamp jaw and a second clamp jaw which are movable in relation to each other between a closed position and an open position. In the closed position, distal ends of the first and second clamp jaws meet to define an enclosed area between the first and second clamp jaws, and in the open position, the distal ends of the first and second clamp jaws are separate from each other to define a gap allowing a wire under test to pass therethrough. The clamp meter further includes a locking member mounted within the meter body. The locking member is operable to releasably lock the first and second clamp jaws in the closed position.

Abstract: A facial puff includes a silicon rubber puff body, an external wrapping layer having waterproof, thin and flexible characteristics and wrapped about the silicon rubber puff body using vacuum packaging technology, and a printing design or ornamental sheet carrying a text, markings, drawings and/or patterns and disposed between the silicon rubber puff body and the external wrapping layer.