Abstract: A system and method for the detection of saliva biomarkers in bodily fluids is described. In particular, the system is suitable for detecting biomarkers of lung cancer in a subject. The system includes an electrochemical sensor chip having at least one well, wherein the at least one well contains a working electrode coated with a conducting polymer functionalized with at least one capture probe, and at least one labeled detector probe. When the at least one labeled detector probe is mixed with a sample of the subject containing a biomarker of lung cancer and added to the at least one well, an electric current is applied to the sample, such that when at least some of the biomarker binds to the capture probe, a measurable change in electric current in the sample is created that is indicative of lung cancer.

Abstract: The present application discloses a method for analyzing a layout pattern density, comprising: step 1, providing layouts of a chip, and merging the layouts to form a wafer level layout, wherein the wafer level layout presents a first circle in a top view, and the layout comprises a plurality of mask layers; step 2, segmenting the first circle to form a plurality of check windows; step 3, searching for the mask layer containing the patterns having a height morphology, and combining the found mask layers into a pattern layer combination; step 4, sequentially calculating a pattern density of the pattern layer combination in each check window; and step 5, recording the pattern density in each check window on a third circle to form a wafer level pattern density distribution diagram. The present application can predict a height morphology of a top surface of a wafer related to a layout.

Abstract: This application provides example detection signal transmitting methods, detection apparatuses, and storage medium. One example method includes determining an orientation of a field of view of a detection apparatus. One of a plurality of anti-interference parameters can then be selected as a target anti-interference parameter based on the orientation of the field of view of the detection apparatus and according to a predefined rule, where the plurality of anti-interference parameters are determined according to the predefined rule. A detection signal can then be transmitted based on the target anti-interference parameter.

Abstract: Methods of recovering a hydrocarbon from a subterranean reservoir include combining a solvent with 0.1 ppm to 10,000 ppm by weight of one or more sulfonate polymers to form a treatment composition; contacting the treatment composition with a crude oil disposed within the reservoir to form a treated crude oil; and collecting the treated crude oil from the reservoir. The sulfonate polymers are selected from poly(methylene naphthalene sulfonate) homopolymers and copolymers, branched or crosslinked polymers having pendant benzenesulfonate moieties, and any combination thereof. The treatment compositions are suitable for umbilical injection into a subsea reservoir. The treated crude oils obtain a 30%-99% reduction in asphaltene fouling compared to an untreated crude oil obtained from the same reservoir.

Abstract: Asphaltene inhibiting compositions include a mixture of a sulfonate material with an amine condensate. The sulfonate material includes one or more sulfonate salts, one or more sulfonate polymers, or a mixture thereof; and the amine condensate includes a reaction product of one or more organic acids with one or more organic compounds having at least two amine groups. The asphaltene inhibiting compositions can form stable injection solutions suitable for use in subsea umbilicals. Combinations of crude oil with the asphaltene inhibiting compositions undergo reduced, or inhibited, asphaltene deposition onto liquid-solid interfaces when compared to asphaltene deposition of the same crude oil in the absence of the composition. The asphaltene inhibiting compositions are particularly effective for inhibiting deposition of coke-like asphaltenes.

Abstract: A method is disclosed for reducing measurement errors on wafer circuit pattern critical dimensions of polycrystal layers: providing wafer circuit patterns to be measured; defining rules to classify the wafer circuit patterns into a first type and a second type, the first type is easily measurable and the second type is not easily measurable with an electron beam linewidth defect scanning machine; for the first type, performing automatic measurement with the machine; for the second type, aligning the user designed wafer circuit patterns manually with the second type of wafer circuit patterns, and performing by the machine to obtain measurement results twice.

Abstract: The present application discloses a method for analyzing a layout pattern density, comprising: step 1, providing layouts of a chip, and merging the layouts to form a wafer level layout, wherein the wafer level layout presents a first circle in a top view, and the layout comprises a plurality of mask layers; step 2, segmenting the first circle to form a plurality of check windows; step 3, searching for the mask layer containing the patterns having a height morphology, and combining the found mask layers into a pattern layer combination; step 4, sequentially calculating a pattern density of the pattern layer combination in each check window; and step 5, recording the pattern density in each check window on a third circle to form a wafer level pattern density distribution diagram. The present application can predict a height morphology of a top surface of a wafer related to a layout.

Abstract: A liquid biopsy system and method for the detection of biomarkers in bodily fluids is described. In particular, the system is suitable for detecting biomarkers of lung cancer in a subject.

Abstract: A system and method for the detection of saliva biomarkers in bodily fluids is described. In particular, the system is suitable for detecting biomarkers of lung cancer in a subject. The system includes an electrochemical sensor chip having at least one well, wherein the at least one well contains a working electrode coated with a conducting polymer functionalized with at least one capture probe, and at least one labeled detector probe. When the at least one labeled detector probe is mixed with a sample of the subject containing a biomarker of lung cancer and added to the at least one well, an electric current is applied to the sample, such that when at least some of the biomarker binds to the capture probe, a measurable change in electric current in the sample is created that is indicative of lung cancer.

Abstract: A system and method for the detection of autoantibodies in saliva is described. In particular, the system is suitable for detecting an autoantibody in a subject, wherein the presence of the autoantibody is indicative of the presence or increased risk of development of an autoimmune disease or disorder.

Abstract: This application provides example detection signal transmitting methods, detection apparatuses, and storage medium. One example method includes determining an orientation of a field of view of a detection apparatus. One of a plurality of anti-interference parameters can then be selected as a target anti-interference parameter based on the orientation of the field of view of the detection apparatus and according to a predefined rule, where the plurality of anti-interference parameters are determined according to the predefined rule. A detection signal can then be transmitted based on the target anti-interference parameter.

Abstract: The present disclosure provides a pattern density analysis method for analyzing a local pattern density of a layout, the method comprising: obtaining a pattern attribute of each layout pattern located on a layout region to be analyzed; setting, for each layout pattern, a relevant window for the layout pattern based on the corresponding pattern attribute; calculating the pattern density of each relevant window; and selecting the maximum value of the pattern densities of the relevant windows as the maximum local pattern density of the layout, and selecting the minimum value of the pattern densities of the relevant windows as the minimum local pattern density of the layout.

Abstract: The present disclosure provides a pattern density analysis method for analyzing a local pattern density of a layout, the method comprising: obtaining a pattern attribute of each layout pattern located on a layout region to be analyzed; setting, for each layout pattern, a relevant window for the layout pattern based on the corresponding pattern attribute; calculating the pattern density of each relevant window; and selecting the maximum value of the pattern densities of the relevant windows as the maximum local pattern density of the layout, and selecting the minimum value of the pattern densities of the relevant windows as the minimum local pattern density of the layout.

Abstract: The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.

Abstract: A simulation method of CMP process comprises: building a CMP model, and forming a matrix table of line width logarithm-density according to the CMP model, and making each intersection of the matrix table correspond to each CMP result under the corresponding line width and density; dividing a layout into a plurality of grids, and converting the equivalent line width and density of each grid into the coordinate of line width logarithm-density in the matrix table; fitting and calculating preliminary CMP simulation results of each grid according to the coordinate of each grid in the matrix table and the CMP simulation results of its adjacent intersections of the matrix table; fitting and computing final CMP simulation results of each grid according to a related weighting factor which considers the impact of adjacent grids for the current grid on the layout; outputting the final CMP simulation results of the whole layout.

Abstract: Certain carrier-free treatment particulates comprising solid treatment chemicals and methods for their formation and of their use in subterranean formations are provided. In one embodiment, the methods comprise: providing a plurality of carrier-free N treatment particulates comprising at least one solid treatment chemical and a coating at least partially disposed around an outer surface of the solid treatment chemical; and introducing the plurality of carrier-free treatment particulates into a well bore penetrating at least a portion of a subterranean formation, wherein the plurality of carrier-free treatment particulates is at least partially consumed in the subterranean formation to create a residual porosity in the portion of the subterranean formation.

Abstract: The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.

Abstract: The invention disclosed a simulation method of CMP process, comprising: firstly, building a CMP model, and forming a matrix table of line width logarithm-density according to the CMP model, and making each intersection of the matrix table correspond to each CMP result under the corresponding line width and density; secondly, dividing a layout into a plurality of grids, and converting the equivalent line width and density of each grid into the coordinate of line width logarithm-density in the matrix table; thirdly, fitting and calculating preliminary CMP simulation results of each grid according to the coordinate of each grid in the matrix table and the CMP simulation results of its adjacent intersections of the matrix table; then, fitting and computing final CMP simulation results of each grid according to a related weighting factor which considers the impact of adjacent grids for the current grid on the layout; finally, outputting the final CMP simulation results of the whole layout.